A5000107458- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Endoplasmic Reticulum Stress and Disease
- Hip and Femur Fractures
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Musculoskeletal pain and rehabilitation
- Autoimmune and Inflammatory Disorders Research
- Epigenetics and DNA Methylation
- Vascular Procedures and Complications
- Congenital heart defects research
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
Central South University
2008-2022
Second Xiangya Hospital of Central South University
2021-2022
Xiangya Hospital Central South University
2008-2022
Guang’anmen Hospital
2022
Third Xiangya Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
National Health and Family Planning Commission
2022
Tianjin Medical University Cancer Institute and Hospital
2020
WuXi AppTec (China)
2019
Huazhong University of Science and Technology
2015
Significance Myelodysplastic syndrome (MDS) represents a common hematopoietic disease, often in elderly patients, with heterogeneous clinical phenotypes and complex disease mechanisms. Here, we report on characteristic genome lesions, clonal architecture, distinct tumor clone expansion patterns group of patients refractory anemia excess blasts, the MDS subtype highest propensity to acute myeloid leukemia. An integrative gene mutation analysis 196 different subtypes allowed regulatory network...
Researchers have recognized that aberrant methylation is an important initiating event in the pathogenesis of hematological malignancies. DNMT3A a DNA methyltransferase plays vital role de novo DNA. Somatic mutation DNMT3A, especially at Arg882 (R882) site coding sequence, has been identified pre-leukemic stem cell clones as one driver mutations acute myeloid leukemia (AML). Statistical analysis indicated patients with AML tend to M4/M5 subtype according French-American-British...
Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the microenvironment (TME). However, underlying role of ER stress-related gene patterns colorectal cancer (CRC) development remains unclear. We analyzed 884 patients with CRC from Gene Expression Omnibus database evaluated cell-infiltrating TME. Two were identified that had distinct TME clinical characteristics. A risk score nomogram based on 14 screened prognosis-correlated...
To present our experience of combining transperitoneal mini-laparoscopic pyeloplasty (mini-LP) and concomitant ureteroscopy-assisted pyelolithotomy (U-P) for ureteropelvic junction obstruction (UPJO) complicated by renal caliceal stones in the same session.Between May 2007 December 2011, mini-LP U-P was performed nine patients with UPJO ipsilateral stones. Stone location burden were preoperatively assessed. After pyelotomy appropriate length (about 4 mm), a 16-Fr catheter sheath replaced...
This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia (BPH). Males over 50 years age who underwent health examinations at Health Management Center Second Xiangya Hospital, Central South University (Changsha, China) from June December 2020 were enrolled in this study. The characteristic data collected, including basic indices, lipid parameters, indicators, prostate-specific antigen, and total prostate volume. odds ratios...
Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening syndrome, which caused by EBV infection that usually refractory to treatment and shows relapse. The development of new biomarkers for the early diagnosis clinical EBV-HLH urgently needed. Exosomes have been shown mediate various biological processes are ideal non-invasive biomarkers. Here, we present differential plasma exosomal proteome patient with before vs. during his healthy twin...
Hip arthroplasty is the most important surgical method for treatment of hip fractures and necrosis in femoral head. Limb function recovery an criterion to reflect efficacy surgery quality life patients. Postoperative rehabilitation exercises are crucial limb recovery. Otago exercise programme (OEP) a safe, effective, practical, economical exercise, which has been proven prevent falls, improve walking ability, lower strength. This study aims explore effect OEP on elderly patients with neck fractures.
Giant tuberculum sellae meningiomas (TSMs) are deeply located in the suprasellar region and extensively compressed or encased surrounding neurovascular structures, making gross total resection (GTR) without postoperative visual impairment challenging. The authors presented individualized unilateral subfrontal approach endoscopic transsphenoidal (ETSA) a series of patients elaborated on their advantages indications resecting giant TSMs.A 38 with TSMs operated by single surgeon between March...
Lung adenocarcinoma (LUAD) is the one of most prevalent and fatal form malignant tumors worldwide. Recently, immunotherapy widely used in treatment patients with LUAD has proved to be clinically effective improve prognosis patients. But there still been a tremendous thrust further efficacy individual LUAD. The suppression T cells their effector functions tumor microenvironment (TME) primary reasons for low some Therefore, identifying positive regulators cell proliferation (TPRs) may offer...
Dear Editor, We identified an immunomodulatory signature that was significantly associated with clinical improvement of immune checkpoint blockade (ICB) therapy response and better prognosis in urothelial carcinoma1 melanoma.2 Our finding is helpful for identifying cancer patients who may benefit from ICB therapy. effective treatment regimen patients. Tumor mutation burden (TMB),3 expression PD-1, PD-L1,4 CTLA-4, are known factors response. However, our understanding biomarkers to remains...
More than 100 genes located on the X chromosome have been found to be associated with X-linked intellectual disability (XLID) date, and
Objective To investigate the correlation between abnormal localization of immature precursors (ALIP)-like structure in bone marrow biopsy and early relapse acute myeloid leukemia (AML).Methods Computer image processing technology was performed to detect distance endosteum,and density also calculated under light microscopic image.Clinical data 40 AML patients with complete remission (CR) were analyzed.Results Beside single double precursors,there clustered 3-5 cells during CR.Clustered...
Abstract Tyrosine Kinase Inhibitor (TKI) of Epidermal Growth Factor Receptor (EGFR) is a first-line therapy for non-small cell carcinoma lung cancer patients with EGFR mutations, but often develop resistance to such target therapy. Recently several PD-1 and PD-L1 inhibitors were approved treating NSCLC, however, it remains unclear whether mutant NSCLC would benefit from PD-1/PD-L1 treatment. response in closely associated oncogenic mutation status, tumor microenvironment, expression burden...