A5005717214- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Skin and Cellular Biology Research
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Silk-based biomaterials and applications
- Cancer-related Molecular Pathways
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Fungal and yeast genetics research
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Peking Union Medical College Hospital
2022-2023
Shanghai Sixth People's Hospital
2022
Shanghai Jiao Tong University
2017-2022
Tongji University
2018-2021
Tongji Hospital
2018-2021
Shanghai First People's Hospital
2017-2019
The dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics the tumour microenvironment (TME). Recent studies have confirmed presence and potential influence microbiome in TME on cancer progression. Elucidating relationship between microbes could provide valuable insights into novel diagnostic markers therapeutic strategies for HCC thus warrants a closer investigation role intratumoural TME.
Abstract Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated role KRT80 prognosis colorectal carcinoma (CRC) and underlying mechanisms involved CRC migration invasion. We analyzed expression using The Cancer Genome Atlas Oncomine databases. Higher was found to be significantly associated with multiple pathological parameters, lower disease-free survival, overall survival patients. Also, independent prognostic indicator for CRC....
Abstract Cancer-associated fibroblasts (CAF) constitute a major component of the tumor microenvironment. The effects CAFs on progression colorectal cancer remain controversial. In this study, we found ectopic overexpression Fibronectin leucine-rich transmembrane protein 3 (FLRT3) inhibited process epithelial–mesenchymal transition (EMT), as well proliferation, migration, invasion, and promote apoptosis cells, whereas silencing FLRT3 expression resulted in opposite phenomenon. downregulation...
Abstract Methods accurately predicting the responses of colorectal cancer (CRC) and liver metastasis (CRLM) to personalized chemotherapy remain limited due tumor heterogeneity. This study introduces an innovative patient‐derived CRC CRLM model for preclinical investigation, utilizing 3d‐bioprinting (3DP) technology. Efficient construction homogeneous in vitro 3D models CRC/CRLM is achieved through application primary cells bioprinting with bioink. Genomic histological analyses affirm that...
Abstract DEAD box RNA helicase 17 (DDX17) is a transcriptional regulator of several transcription factors, which more appreciated than its role in metabolism. However, prognostic value and biofunction DDX17 HCC remain unclear. Illuminating the mechanism underlying regulating progression by may contribute to therapeutic strategies. In our study, we report for first time that was overexpressed specimens using The Cancer Genome Atlas (TCGA) immunohistochemistry (IHC) correlated clinical...
The existing in vitro models for antitumor drug screening have significant limitations. Many compounds that inhibit two-dimensional (2D) cultured cells do not exhibit the same pharmacological effects vivo, thereby wasting human and material resources time during development. Therefore, it is crucial to develop new models. Three-dimensional (3D) bioprinting technology has greater advantages constructing tissues than sandwich culture organoid construction. We used 3D construct a multicellular...
Bone metastasis (BM) dramatically reduces the quality of life and expectancy in lung adenocarcinoma (LUAD) patients. There is an urgent need to identify potential biomarkers for application treatment this deadly disease. We compared patient BM, LUAD, para-LUAD tissues using proteomic analysis identified aldehyde dehydrogenase 2 (ALDH2), which can detoxify acetaldehyde acetic acid, as one key regulators tumor metastasis. Both mRNA protein levels ALDH2 were significantly lower than normal...
The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe new CRC tumor suppressor potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. expression TOX was lower in than para-CRC. With the increase stage, decreased, indicating presence relates to better overall survival (OS). suppressed mechanistic target rapamycin kinase (mTOR) signaling inhibit cell proliferation, migration,...
The current gold standard for the clinical diagnosis of portal hypertension (PH) is an invasive and indirect estimation vein pressure (PVP). Therefore, need a non-invasive PVP measurement method urgent. Subharmonic scattering ultrasound contrast agent (UCA) microbubbles under investigation in research as indicator. However, driving acoustic must be optimized to improve ambient sensitivity subharmonic amplitude different UCAs. In this study, first time, we obtained relationship between signal...
The acquisition of real-time portal vein pressure (PVP) is important for hypertension (PH) discrimination to monitor disease progress and select treatment options. To date, the PVP evaluation approaches are either invasive or noninvasive but with less stability sensitivity.
Epidermolysis bullosa (EB) is a heritable blistering disorder. We performed next-generation sequencing-based multigene panel test and successfully predicted 100% of the EB types, including, 36 simplex (EBS), 13 junctional (JEB), 86 dystrophic (DEB), 3 Kindler EB. Chinese JEB recessive DEB (RDEB) patients have relatively mild phenotypes; for severe type separately accounts 45.5% 23.8%, respectively. identified 96 novel 49 recurrent pathogenic variants in 11 genes, although we failed to detect...
Aim: The effect of SLC28A3 on tacrolimus disposition and new-onset hypertension (NOHP) after liver transplantation (LT) remains unclear. Methodology & results: A total 169 patients in two cohorts from the China Liver Transplant Registry database were included. Rs7853758 recipients'SLC28A3 could predict pharmacokinetics sets. model donors' CYP3A5 rs776746 recipients' CYP3A4 rs2242480 metabolism at week 1 rs776746, rs2242480, rs7853758 hemoglobin weeks 2, 3 4. Besides, was a new risk factor...
There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in survival of patients and what may cause this still unclear. A total 12,312 were enrolled study. Age, race, sex, grade, tumor TNM stage, marital status, size, histological type independent risk confirmed validation cohort. Before menopause, females demonstrated better mean probability than males (39.4±1.4 vs. 32.7±0.8 months, respectively;...
Background: Orthotopic liver transplantation (OLT) improves the prognosis of patients with hepatocellular carcinoma (HCC). Moreover, complement system is a powerful immune effector that can affect function and process cirrhosis. However, studies correlating tacrolimus metabolism after OLT are scarce. In this study, role single nucleotide polymorphisms (SNPs) associated sixth component (C6) in was investigated during early stages transplantation. Methods: The study enrolled 135 adult treated...
Deleted in Breast Cancer 1 (DBC1/CCAR2) is a regulatory protein involved cell survival and cancer progression. Herein, we focused on summarizing the overall prognostic value of DBC1 for digestive system cancers. Therefore, conducted meta-analysis based 9 studies with 2391 patients to generated combined hazard ratios (HR) or odds ratio (OR) its 95% confidence intervals (CI) (OS) clinicopathological features. Positive expression was significantly associated poor OS cancers (pooled HR=1.650,...
Hepatic function restoration is the main process taking place after liver transplantation. Albumin-bilirubin (ALBI) grade a new tool for assessing severity of dysfunction. This evidence-based model solely based on serum bilirubin and albumin levels, which could help clinicians obtain more objective scale that guides disease diagnosis treatment.Total amounts, other biochemical indicators were determined in total 75 adult patients who underwent orthotopic transplantation (OLT) HCC. The aim...
Supplementary Figure from TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer
Supplementary Figure from TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer