A5067017492- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Microfluidic and Bio-sensing Technologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Planarian Biology and Electrostimulation
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Peking Union Medical College Hospital
2022-2024
The dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics the tumour microenvironment (TME). Recent studies have confirmed presence and potential influence microbiome in TME on cancer progression. Elucidating relationship between microbes could provide valuable insights into novel diagnostic markers therapeutic strategies for HCC thus warrants a closer investigation role intratumoural TME.
Cell-laden bioprinting is a promising biofabrication strategy for regenerating bioactive transplants to address organ donor shortages. However, there has been little success in reproducing transplantable artificial organs with multiple distinctive cell types and physiologically relevant architecture. In this study, an omnidirectional printing embedded network (OPEN) presented as support medium 3D printing. The state-of-the-art due its one-step preparation, fast removal, versatile ink...
Abstract Methods accurately predicting the responses of colorectal cancer (CRC) and liver metastasis (CRLM) to personalized chemotherapy remain limited due tumor heterogeneity. This study introduces an innovative patient‐derived CRC CRLM model for preclinical investigation, utilizing 3d‐bioprinting (3DP) technology. Efficient construction homogeneous in vitro 3D models CRC/CRLM is achieved through application primary cells bioprinting with bioink. Genomic histological analyses affirm that...
Objective: To investigate the correlation between hypothyroidism and serum creatine kinase (CK) levels in patients with differentiated thyroid cancer (DTC) during radioactive iodine (131I) therapy following total thyroidectomy. Methods: This prospective study enrolled 170 DTC (50 males 120 females) a mean age of 39.41±9.45 years, who were treated at First Affiliated Hospital Zhengzhou University from January 2023 to June 2023. Thyroid-related hormones CK measured two time points: one month...
Acoustic holography (AH), a promising approach for cell patterning, emerges as powerful tool constructing novel invitro 3D models that mimic organs and cancers features. However, understanding changes in function post-AH remains limited. Furthermore, replicating complex physiological pathological processes solely with lines proves challenging. Here, we employed acoustical holographic lattice to assemble primary hepatocytes directly isolated from mice into cluster matrix construct...
Immunologic checkpoint inhibitors (ICIs) have demonstrated efficacy in a variety of malignancies. Despite impressive therapeutic benefits, ICIs may induce profound immune-related adverse events (irAEs). While the occurrence irAEs implicate improved T cell activity, whether predicts anti-tumor immune responses remains controversial. The paper by Kennedy Yao Yi Ng et al. adds to evidence impact advanced hepatocellular carcinoma, which that multi-system involvement positively correlated with...
Background: Short-term outcomes of laparoscopic hepatectomy central-located liver lesions (LHCL) compared with traditional open (OHCL) remain unclear. The aim this study was to explore the safety and efficacy LHCL. Methods: A retrospective analysis performed on 262 patients who underwent hepatectomies involving resections segment II, IV or VIII from January 2015 June 2021 in two institutions. Patients LHCL group were matched a 1:2 ratio OHCL group. Results: After propensity score-matched...