A5103113184- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Hydrogels: synthesis, properties, applications
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Redox biology and oxidative stress
- Tea Polyphenols and Effects
- Cancer Research and Treatments
- Surfactants and Colloidal Systems
- Coagulation and Flocculation Studies
- Advanced Materials and Mechanics
- Colorectal Cancer Screening and Detection
- Fungal and yeast genetics research
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
Shanghai First People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
University of Alabama at Birmingham
2023
Qingdao University of Science and Technology
2017-2019
// Dantong Cheng 1, * , Senlin Zhao 5, Huamei Tang 2, Dongyuan Zhang 1 Hongcheng Sun Fudong Yu Weiliang Jiang 4, Ben Yue Jingtao Wang Meng 3 Yang Xisheng Liu Xiaofeng 5 Zongguang Zhou 6 Xuebin Qin 7 Xin 8 Dongwang Yan Yugang Wen Zhihai Peng Department of General Surgery, Shanghai Hospital, School Medicine, Jiao Tong University, Shanghai, China 2 Pathology, Fudan University Affiliated Cancer Center, 4 Gastroenterology, Jiaotong Oncology and Clinical Experimental Linköping Linköping,...
We previously discovered that Ras association domain family member 6 (RASSF6) was downregulated and predicted poor prognosis in GC patients. However, the mechanisms of down regulation RASSF6 remained unclear. Increasing evidence indicates dysregulation microRNAs promotes progression cancer through repression tumour suppressors. Here, we identified miR-181a-5p as a novel regulator GC. Functionally, ectopic expression or silencing miR-181a-5p, respectively, promoted inhibited cell...
USP11 is an ubiquitin-specific protease that plays important role in tumor progression via different mechanisms. However, the expression and prognostic significance of colorectal cancer (CRC) remain unknown.Bioinformatics analyses, qRT-PCR, western blotting, immunohistochemistry were applied for investigating CRC tissues. Kaplan-Meier analysis with log-rank test was used survival analyses. LC-MS/MS performed identifying potential protein interactions USP11. In vitro vivo assays exploring...
Diabetic patients have a higher risk factor for colorectal cancer (CRC) metastasis. Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible producing monounsaturated fatty acids(MUFA) from saturated acids, is frequently deregulated in both diabetes and CRC. The function mechanism of SCD1 metastasis CRC its relevance to glucose remains largely unknown. expression levels were analyzed human tissues Cancer Browser database ( https://genome-cancer.ucsc.edu/ ). cell lines stably transfected...
Despite advancements in the diagnosis and treatment of colorectal cancer (CRC), many patients die because tumor metastasis or recurrence. Therefore, identifying new prognostic markers elucidating mechanisms CRC recurrence will help to improve prognosis disease. As dysregulation microRNAs is strongly related progression, aim this study was identify role miR-4775 underling involved progression. qPCR situ hybridization were used evaluate expression 544 pairs paraffin-embedded normal tissues....
Abstract Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated role KRT80 prognosis colorectal carcinoma (CRC) and underlying mechanisms involved CRC migration invasion. We analyzed expression using The Cancer Genome Atlas Oncomine databases. Higher was found to be significantly associated with multiple pathological parameters, lower disease-free survival, overall survival patients. Also, independent prognostic indicator for CRC....
Abstract Increasing evidence suggests that global downregulation of miRNA expression is a hallmark human cancer, potentially due to defects in the processing machinery. In this study, we found protein Argonaute 2 (AGO2), key regulator processing, was downregulated colorectal cancer (CRC) tissues, which also consistent with findings Clinical Proteomic Tumor Analysis Consortium (CPTAC). Furthermore, correlation between levels AGO2 and epithelial-mesenchymal transition (EMT) markers (E-cadherin...
// Senlin Zhao 1, * , Huamei Tang 2, Dongwang Yan Junwei Fan Hongcheng Sun 1 Yugang Wen Fudong Yu Feifei Cui Dongyuan Zhang Yingming Xue Chenchen Liu Ben Yue Jian Chen Jingtao Wang Xiao Meng 3 Yang Weiliang Jiang 4 Xisheng Yushuai Mi Zongguang Zhou 5 Xuebin Qin 6 Zhihai Peng Department of General Surgery, Shanghai First People's Hospital, Affiliated to Jiao Tong University, Shanghai, China 2 Pathology, Fudan University Cancer Center, Gastroenterology, Jiaotong Gastrointestinal West Sichuan...
Adjuvant chemotherapy is considered the standard of care for patients with colorectal cancer after curative resection. Although current guidelines provide clear instructions stage II high-risk and III cancer, it insufficient to individualize therapy. We analyzed outcomes 902 treated or without in our hospital. found Chinese survival benefit was consistent guidelines. Moreover, data added evidence that might be used elderly cancer. Pathological markers could predict response therapy a...
Abstract Sodium alginate was hydrophobically modified with dodecenyl succinic anhydride in a neutral aqueous solution (pH = 6.8) at room temperature, forming an environmentally friendly amphiphile dodecenyl‐modified (DMA). Surface activity of DMA assessed using surface tension and zeta‐potential measurements. Hydrophobic compound‐loading capacity as well oil‐in‐water emulsion stability solutions were investigated to study the potential applications DMA. The critical micelle concentration...
The nylon 66/nano-CaCO3 composites were prepared by melt blending on a twin-screw extruder. Scanning electron microscopy (SEM), polarized light (PLM), thermal loss (TGA) and differential scanning calorimetry (DSC) effects of nanometer calcium carbonate the polycrystalline behavior properties 66/nano CaCO3 investigated. results show that particles are dispersed in 66 matrix exist form aggregates. has effect heterogeneous nucleation, which can reduce size spherules. decomposition temperature is...
<div>Abstract<p>Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of digestive tract. In past, tissue biopsy was main method for diagnosis GISTs. Although, circulating DNA (ctDNA) detection by next-generation sequencing (NGS) may be a feasible and replaceable We retrospectively analyzed data ctDNA from 32 advanced GIST patients. found that NGS obviously increased positive rate detection. identified rare mutations were not detected in Tumor size Ki-67...
<div>Abstract<p>Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumor of digestive tract. In past, tissue biopsy was main method for diagnosis GISTs. Although, circulating DNA (ctDNA) detection by next-generation sequencing (NGS) may be a feasible and replaceable We retrospectively analyzed data ctDNA from 32 advanced GIST patients. found that NGS obviously increased positive rate detection. identified rare mutations were not detected in Tumor size Ki-67...
Figure S2. Glucose promotes migration and invasion of SW116 cells. (A) Transwell assay cells treated with 0 mM (G0), 5.5 mM (G5.5), 11 mM (G11) or 25 mM (G25) glucose. The scale bar is 100 μm. (B, C) Histograms show the number migrated (B) invasive (C) (TIFF 1154 kb)
Figure S1. SCD1 promotes migration and invasion of SW116 cells. (A) Quantification results in HCT116 cells transfected with shRNAs for (sh1 sh2) or Caco2 ectopically expressing SCD1. (B) Representative Western blot quantified sh2). (C) Transwell assay after knockdown. The scale bar is 100Â Iźm. (D, E) Histograms show the numbers migrated (D) invasive (E) (TIFF 1383Â kb)
Figure S4. PTEN mediates SCD1-induced migration and invasion of SW116 cells. (A) Representative Western blot SCD1, β-Catenin, STAT3, S6K JNK in CRC cells transfected with shSCD1 or SCD1 cDNA. (B) quantification data siRNAs for (si1 si2). (C) photographs transwell assays shNC-transfected after being (siPTEN) negative control scramble (siNC). The scale bar is 100 μm. (D, E) Histograms show the numbers migrated (D) invasive (E) (F) blots quantified results PTEN, Akt, p-Akt (Ser473), (Thr308),...