A5103054281- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- TGF-β signaling in diseases
- Diverse Scientific Research Studies
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- Multiple and Secondary Primary Cancers
- Viral-associated cancers and disorders
- Lipid metabolism and biosynthesis
- Food composition and properties
- Gastric Cancer Management and Outcomes
- Medicinal Plants and Bioactive Compounds
- Image and Object Detection Techniques
- Plant Reproductive Biology
- Biofuel production and bioconversion
China Agricultural University
2025
Shanghai Jiao Tong University
2015-2024
Shanghai First People's Hospital
2015-2024
Shandong Provincial QianFoShan Hospital
2018-2023
Shandong First Medical University
2021-2023
Institute of Laboratory Animal Science
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Peking Union Medical College Hospital
2021
East China University of Science and Technology
2020
Institute of Crop Sciences
2020
Abstract Background Long non‐coding RNA‐activated by TGF‐β (lncRNA‐ATB) promotes the invasion–metastasis cascade in hepatocellular carcinoma via downregulating E‐cadherin (E‐cad) and inducing epithelial‐to‐ mesenchymal transition (EMT) is clinically significant human colon cancer. However, its molecular mechanisms cancer progression remain unclear. This study aimed to elucidate role of lncRNA‐ATB clinical value Methods Expression levels tissues cell lines were evaluated using quantitative...
// Dantong Cheng 1, * , Senlin Zhao 5, Huamei Tang 2, Dongyuan Zhang 1 Hongcheng Sun Fudong Yu Weiliang Jiang 4, Ben Yue Jingtao Wang Meng 3 Yang Xisheng Liu Xiaofeng 5 Zongguang Zhou 6 Xuebin Qin 7 Xin 8 Dongwang Yan Yugang Wen Zhihai Peng Department of General Surgery, Shanghai Hospital, School Medicine, Jiao Tong University, Shanghai, China 2 Pathology, Fudan University Affiliated Cancer Center, 4 Gastroenterology, Jiaotong Oncology and Clinical Experimental Linköping Linköping,...
Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been confirmed to play crucial regulatory roles in tumor progression. It exerts an impact on suppression and functions as a competing endogenous (ceRNA) by sponging miR-106a-5p gastric cancer. However, its clinical significance colon cancer is completely unknown. The aim of the present study was annotate role FER1L4 value results showed aberrant expression tissues. In addition, significant negative correlation between levels...
We previously discovered that Ras association domain family member 6 (RASSF6) was downregulated and predicted poor prognosis in GC patients. However, the mechanisms of down regulation RASSF6 remained unclear. Increasing evidence indicates dysregulation microRNAs promotes progression cancer through repression tumour suppressors. Here, we identified miR-181a-5p as a novel regulator GC. Functionally, ectopic expression or silencing miR-181a-5p, respectively, promoted inhibited cell...
Despite advancements in the diagnosis and treatment of colorectal cancer (CRC), many patients die because tumor metastasis or recurrence. Therefore, identifying new prognostic markers elucidating mechanisms CRC recurrence will help to improve prognosis disease. As dysregulation microRNAs is strongly related progression, aim this study was identify role miR-4775 underling involved progression. qPCR situ hybridization were used evaluate expression 544 pairs paraffin-embedded normal tissues....
Abstract Doxorubicin (Dox), a potent antitumor drug, is linked to cardiac toxicity. Few mechanism‐based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes Dox‐induced cardiomyopathy. It aimed at exploring the association between specific mechanism of reprogramming and Cardiac‐specific ablation Slc25a49 mice generated by crossing flox/flox with Myh6‐Cre mice. HKO or SLC25A49 KD cardiomyocytes treated Dox. Echocardiography, histological...
Human BarH-like homeobox 2 (Barx2), a homeodomain factor of the Bar family, has an important role in controlling expression cell adhesion molecules and been reported increasing array tumor types except colorectal cancer (CRC). The purpose current study was to characterize Barx2 assess clinical significance CRC. First, we analyzed two independent public datasets from Oncomine. Subsequently, evaluated mRNA protein by quantitative real-time PCR western blotting, respectively. It determined that...
Second primary malignancies (SPMs) after liver transplantation (LT) are becoming the leading causes of death in LT recipients. The purpose this study was to explore prognostic factors for SPMs and establish an overall survival nomogram.A retrospective analysis conducted data from Surveillance, Epidemiology, End Results (SEER) database on adult patients with hepatocellular carcinoma who had undergone between 2004 2015. Cox regression used independent SPMs. Nomogram constructed using R...
// Senlin Zhao 1, * , Huamei Tang 2, Dongwang Yan Junwei Fan Hongcheng Sun 1 Yugang Wen Fudong Yu Feifei Cui Dongyuan Zhang Yingming Xue Chenchen Liu Ben Yue Jian Chen Jingtao Wang Xiao Meng 3 Yang Weiliang Jiang 4 Xisheng Yushuai Mi Zongguang Zhou 5 Xuebin Qin 6 Zhihai Peng Department of General Surgery, Shanghai First People's Hospital, Affiliated to Jiao Tong University, Shanghai, China 2 Pathology, Fudan University Cancer Center, Gastroenterology, Jiaotong Gastrointestinal West Sichuan...
Circular RNA hsa_circ_0088364 (circ_0088364) is a contributory factor in the malignancy of hepatocellular carcinoma (HCC). We aimed to elaborate its role and competing endogenous (ceRNA) mechanism HCC cell growth motility. Expression circ_0088364, microRNA (miR)-1270 Collagen type IV alpha 1 chain (COL4A1) was measured by real-time quantitative PCR Western blotting, their relationships were determined dual-luciferase reporter assay, immunoprecipitation, biotinylated pull-down, Spearman's...
Pancreatic adenocarcinoma (PAAD) is a malignant tumor with high mortality rate. Methylation modifications acted crucial role to affect cancer progression. The current study aimed explore the potential of methylase regulators in PAAD prognosis and immune microenvironment.PubMed TCGA databases were used systematically analyze PAAD. We identified three clusters based on RNA transcriptome data obtained gene modification-related differently expressed genes using principal component analysis (PCA)...
Traditional CNN-based training for instance segmentation is time-consuming owing to large datasets and complex network modules, making direct searching of architecture challenging. In this paper, we introduce an efficient framework, named EASInst. It can discover practical backbone encoder architectures the improved sparse activation model. Specifically, construct a supernet both modules SparseInst based on differentiable method. addition, kernel sharing mask channel pruning technology are...
For decades, experimental animal models have been powerful tools for biomedical research and supported most of the physiological or medical achievements recognized by Nobel Prizes, including that won this year's Physiology Medicine Prize. On 4th October 2021, Prize in 2021 was awarded jointly to David Julius Ardem Patapoutian "for their discoveries receptors temperature touch."1 Their profoundly changed our view how we sense world around us.2 The senses touch are among basic functions...
Objective To explore the effects of interleukin-6 (IL-6) gene knockout on cognitive function and pathological changes in 5×FAD transgenic mice Alzheimer's disease.Methods IL-6+/- were crossed with to establish 5×FAD;IL-6-/- mouse model,and 3-month-old 10-month-old selected for experiments.The was detected by behavioral tests,and HE staining β-amyloid (Aβ) immunohistochemical performed detect brain tissue.Results The number model (3 months old,n=20;10 old,n=5) littermate control old,n=26;10...