A5013935300- Cancer-related molecular mechanisms research
- interferon and immune responses
- Influenza Virus Research Studies
- RNA modifications and cancer
- Meat and Animal Product Quality
- Bone Metabolism and Diseases
- Respiratory viral infections research
- Aquaculture Nutrition and Growth
- Electrocatalysts for Energy Conversion
- Curcumin's Biomedical Applications
- Thermochemical Biomass Conversion Processes
- Fibroblast Growth Factor Research
- Biosensors and Analytical Detection
- Proteins in Food Systems
- HIV/AIDS drug development and treatment
- Advanced battery technologies research
- Protein Hydrolysis and Bioactive Peptides
- Advanced biosensing and bioanalysis techniques
- Bone health and osteoporosis research
- Neonatal Respiratory Health Research
- Frailty in Older Adults
- Proteoglycans and glycosaminoglycans research
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Coal and Coke Industries Research
Wenzhou Medical University
2023-2025
Chinese PLA General Hospital
2019-2025
Zhengzhou Central Hospital
2024
Institute of Microbiology
2015-2024
Jining First People's Hospital
2024
Hunan Agricultural University
2023-2024
State Key Laboratory of Chemical Engineering
2022-2023
Beijing University of Chemical Technology
2022-2023
East China University of Science and Technology
2022-2023
Jiangxi Normal University
2023
Abstract Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines employed to improve clinical outcomes RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against lung injury induced by RSV an experimental mouse model pediatric Moreover, ACE2...
BackgroundAzvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression severe infection. We sought compare the antiviral effectiveness clinical outcomes of elderly patients COVID-19 receiving these two agents.MethodsIn this observational study, we identified 249 infection who were admitted Second Medical Center People's Liberation Army General Hospital from December 2022 January 2023, including 128...
Accumulating studies have shown that long non-coding RNAs (lncRNAs) modulate multiple biological processes, including immune response. However, the underlying mechanisms of lncRNAs regulating host antiviral response are not well elucidated. In this study, we report analysis existing dataset transcriptome blood cells patients with influenza A virus (IAV) infection and after recovery (GSE108807) identified a novel lncRNA, termed as IVRPIE (Inhibiting IAV Replication by Promoting IFN ISGs...
Abstract Fast and ultrasensitive detection of pathogens is very important for efficient monitoring prevention viral infections. Here, we demonstrate a label‐free optical approach that uses printed nanochain assay colorimetric quantitative testing viruses. The antibody‐modified nanochains have high activity specificity which can rapidly identify target viruses directly from biofluids in 15 min, as well differentiate their subtypes. Arising the resonance induced near‐field enhancement, color...
Diethylenetriamine-grafted PAN fibers with high grafting rates using a hydrothermal method exhibit Cu 2+ adsorption capacities at high/low concentrations.
ABSTRACT This study aims to identify the risk factors associated with clinical outcomes and proteomic changes in organs related fatal SARS‐CoV‐2 infection within super‐elderly population. retrospective analysis included all elderly individuals COVID‐19 admitted Second Medical Center of PLA General Hospital from December 2022 January 2023. The follow‐up period ended on March 30, During this time, epidemiological, demographic, laboratory, outcome data were analyzed descriptively. Proteomic...
Biological age (BA) is regarded as a more accurate marker of aging than chronological and commonly used to assess associations with age-related diseases. The relationship between BA measures the colorectal cancer (CRC) has not yet been investigated. This study utilized data from National Health Nutrition Examination Survey. was quantified using Klemera-Doubal method (KDMAge) phenotypic (PhenoAge), based on 13 common clinical biomarkers. prevalence CRC across quartiles indicators compared...
Background: To investigate in vitro how scrapie responsive gene 1 (SCRG1) contributes to the development of temporomandibular joint osteoarthritis (TMJOA). Methods: Western blotting was used identify protein expression. Proinflammatory cytokine levels were assessed by means an enzyme-linked immunosorbent test. In order find out whether chondrocytes expressed light chain 3B (LC3B), immunofluorescence utilized. Results: TMJOA model, hydrogen peroxide (H2O2) treatment increased expression...
Summary To study the effects of freezing temperature on muscle proteins, shrimp ( Metapenaeus ensis ) were frozen stored at either −18 or −60 °C up to 90 and 210 days. Shrimp had higher thawing compression loss poor myofibril water‐holding capacity compared with those °C. In terms protein characteristics, levels carbonyls reduced sulphhydryls. Moreover, surface hydrophobicity Ca 2+ ‐ATPase activity, indicating increased denaturation. Proteomics revealed that seventy‐five proteins classified...
Influenza virus (IAV) infection is a major cause of severe respiratory illness that affects almost every country in the world. IAV infections result and even acute lung injury death, but underlying mechanisms responsible for pathogenesis have not yet been fully elucidated. In this study, basic fibroblast growth factor 2 (FGF2) level was markedly increased H1N1 virus-infected humans mice. FGF2, which predominately derived from epithelial cells, recruits activates neutrophils via...
An avian-origin influenza A (H7N9) virus was a cause for concern in China the spring of 2013. Most H7N9 infections resulted acute respiratory distress syndrome (ARDS), which is severe form lung injury (ALI) that contributes to morbidity and mortality. In this study, we induced viral ALI by infecting wild-type CCL2-deficient mice with virus. The results suggested close association between C-C motif chemokine ligand 2 (CCL2) expressions lethal strain (A/Hebei/01/2013). Elevated CCL2 levels...
Osteoporosis, one of the serious public health problems worldwide, can lead to degeneration bone structure and increased risk fractures. Epigallocatechin gallate (EGCG) is a natural product with potential efficacy in inhibiting loss. However, specific mechanism remains unclear. This study first investigated role EGCG preventing dexamethasone (DEX)-induced osteoporosis by regulating intestinal microbiota serum metabolites. We detected density, microstructure, changes microorganisms According...
Fibroblast growth factor 2 (FGF2 or basic FGF) regulates a wide range of cell biological functions including proliferation, angiogenesis, migration, differentiation, and injury repair. However, the roles FGF2 underlying mechanisms action in influenza A virus (IAV)-induced lung remain largely unexplored. In this study, we report that microRNA-194-5p (miR-194) expression is significantly decreased A549 alveolar epithelial cells (AECs) following infection with IAV/Beijing/501/2009 (BJ501). We...
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infection in infants and children, but there still no licensed vaccine available. In this report, we developed virus-like particle (VLP) vaccines based on the Bac-to-Bac baculovirus expression system, consisting an influenza matrix (M1) protein RSV fusion (F) or glycoprotein (G). These VLPs were identified by western blot analysis electron microscopy. Female BALB/c mice immunized intranasally (i.n.) with RSV-F VLPs,...
Summary To prepare a milk protein‐enriched ink for extrusion‐based 3D food printing, this study investigated the effects of wide range hydrocolloids on microstructures, viscoelastic characteristics and printing performance protein concentrate (MPC). The distributions in mixed coacervates were characterised by fluorescent covalent labelling confocal laser scanning microscope (CLSM), microstructure was observed electron microscopy (SEM). In addition, rheological properties prepared...