A5101484908- Supramolecular Self-Assembly in Materials
- Alzheimer's disease research and treatments
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Advanced Photocatalysis Techniques
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Molecular Junctions and Nanostructures
- Surface Chemistry and Catalysis
- Cancer Genomics and Diagnostics
- Crystallization and Solubility Studies
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- Molecular spectroscopy and chirality
- X-ray Diffraction in Crystallography
- Spectroscopy and Quantum Chemical Studies
- Graphene and Nanomaterials Applications
- Force Microscopy Techniques and Applications
- Polydiacetylene-based materials and applications
- Copper-based nanomaterials and applications
- Graphene research and applications
- Photoreceptor and optogenetics research
- Liquid Crystal Research Advancements
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
China Agricultural University
2025
Xidian University
2024
Heilongjiang University of Science and Technology
2022-2023
Northwest University
2020-2022
University of Wisconsin–Madison
2014-2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020-2021
Peking Union Medical College Hospital
2020
Institute of Physiology and Basic Medicine
2020
Academy of Medical Sciences
2020
By combining atomic force microscopy and trans-port measurements, we systematically investigated effects of thermal annealing on surface morphologies electrical properties single-layer graphene devices fabricated by electron beam lithography silicon oxide (SiO(2)) substrates. Thermal treatment above 300 °C in vacuum was required to effectively remove resist residues surfaces. However, at high temperature found concomitantly bring close contact with SiO(2) substrates induce increased coupling...
Abstract Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies, as well veiled dielectric-responsive character, are instrumental in electromagnetic dissipation. Conventional methods, however, constrain their delicate constructions. Herein, an innovative alternative is proposed: carrageenan-assistant cations-regulated (CACR) strategy, which induces a series of sulfides nanoparticles rooted situ on the surface carbon matrix. This unique configuration...
We report studies on surface modification of graphene with 1-octadecanethiol and its application as heavy metal sensors. The alkanethiol molecules can self-assemble into large-scale highly ordered monolayers single-layer regardless the roughness surfaces inherited from underlying amorphorous silicon oxide (SiO2) dielectric substrates. Atomically resolved scanning tunneling microscopy imaging modified sheets SiO2 was conducted to reveal configuration details self-assembled structure....
Abstract Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against resistance but suffer from low efficiency poor stability. Here, we develop peptide nanozymes which mimic the mode of action AMPs AMEs through de novo design assembly. Through modelling a minimal building block IHIHICI is proposed by combining critical amino acids in hydrophobic isoleucine to conduct Experimental validations reveal that assemble into helical β-sheet nanotubes with...
Core–sheath silver nanowire/polyvinylpyrrolidone (AgNW/PVP) nanocables have been fabricated via an efficient single-spinneret electrospinning method. The core–sheath structure is revealed by combining several characterization methods. A possible formation mechanism of the AgNW/PVP nanocable involving a strong stretching during process proposed. Further, electrical measurements were performed on as well bare AgNWs, which indicated became insulating due to isolation highly conductive AgNWs PVP...
Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity nanomaterials to humans. In particular, been linked lung diseases. The molecular mechanisms nanoparticle largely unexplored.Acute injury was induced wild-type mice and angiotensin-coverting enzyme 2 (ACE2) knockout by intratracheal instillation cationic polyamidoamine dendrimer (PAMAM) nanoparticles. For rescue experiments, losartan (15 mg/kg PBS) injected intraperitoneally...
The pathogenesis of type II diabetes can be linked to cosecreted hIAPP/insulin interacting with cell membranes. Here we investigate the nanostructures by co-assembling hIAPP and insulin on surfaces. By tuning ratio, atomic force microscopy reveals resulting nanostructure morphology changes from fibrils oligomers, annular. Implications for in vivo studies are discussed.
We explore how two nonionic polar groups (primary amine and primary amide) influence hydrophobic interactions of neighboring nonpolar domains. designed stable β-peptide sequences that generated globally amphiphilic (GA) helices, each with a domain formed by six cyclohexyl side chains arranged along one the 14-helix. The other helix was dominated three chains, from β3-homolysine (K) and/or β3-homoglutamine (Q) residues. Variations in this chain array included exclusively β3-hLys (GA-KKK)...
Nonviral vectors are highly desirable for the development of efficient gene delivery systems. In this study, we report monomolecular condensation plasmid DNA and cell transfection by imidazolium gemini surfactants ([C12-4-C12im]Br2), which could be a potential nonviral vector therapy. Homogeneous DNA/[C12-4-C12im]Br2 nanoparticles formed with diameter approximately 100 nm investigated using atomic force microscopy. condensates evolve from supercoiled molecules, to individual toroids,...
Phenol-soluble modulin α3 (PSMα3) is a cytotoxic peptide secreted by virulent strains of Staphylococcus aureus. We used stereochemical strategy to examine the mechanism PSMα3-mediated toxicity. One hypothesis that PSMα3 toxicity requires fibril formation; an alternative caused soluble forms PSMα3, possibly oligomeric. find unnatural enantiomer (D residues) displays cytotoxicity comparable L-PSMα3. Racemic similarly toxic enantiopure (L or D) under some conditions, but lost conditions cause...
We report an experimental investigation of the influence molecular-level order (crystallinity) within nonpolar monolayers on hydrophobic interactions. The measurements were performed using gold film-supported formed from alkanethiols (CH3(CH2)nSH, with n ranging 3 to 17), which we confirmed by polarization–modulation infrared reflection–adsorption spectroscopy exhibit chain-length-dependent (methylene peak moves 2926 2919 cm–1, corresponding a transition liquid- quasi-crystalline-like order)...