A5100684189- RNA Interference and Gene Delivery
- Sulfur Compounds in Biology
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Microbial Metabolic Engineering and Bioproduction
- MicroRNA in disease regulation
- Protein Structure and Dynamics
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Ion channel regulation and function
- Enzyme Structure and Function
- Cancer-related Molecular Pathways
- Endoplasmic Reticulum Stress and Disease
- Amino Acid Enzymes and Metabolism
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
- Nanoparticle-Based Drug Delivery
- Fluorine in Organic Chemistry
- Nitric Oxide and Endothelin Effects
- Microbial Natural Products and Biosynthesis
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
Shanghai Zhabei District Shibei Hospital
2025
Huadong Hospital
2025
Fudan University
2025
Weifang Medical University
2024
Xiangtan University
2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2024
Southern Medical University
2013-2023
Nanfang Hospital
2013-2023
Jiangnan University
2023
About half of human cancers are associated with mutations the tumor suppressor p53. Gained oncogenic functions mutants have been related to aggregation behaviors wild-type and mutant The thermodynamic kinetic mechanisms p53 poorly understood. Here we find that forms an anomalous liquid phase. condensates exhibit several beyond scope classical phase transition theories: their size, ca. 100 nm, is independent concentration decoupled from protein mass held in Furthermore, lacks constant...
Abstract High temperatures (HT) before heading strongly inhibit the development of spikelets in rice. Spermidine (Spd) can improve rice’s resistance to HT stress; however, mechanism underlying this effect has not been elucidated. This study investigated several parameters, including yield, superoxide anion (O 2 .- ), protective enzyme activities, and polyamine content, a heat-sensitive genotype, Shuanggui 1. The yield components decreased dramatically when subjected stress, while reduction...
The Gram-negative rod-shaped bacterium Serratia marcescens is an opportunistic pathogen of many organisms, including insects. We report the identification and optimal in vitro chitinase production conditions a novel chitinolytic S. strain TC-1 isolated from naturally infected white grub (Anomala corpulenta) collected peanut field at Nanyang city, Henan province, China. Strain was conducted by morphological, physiological, biochemical molecular analyses. amplified 16S rRNA gene showed...
Drug-drug cocrystals and coamorphous systems, both comprising two drugs in a single phase, can be applied to concurrently improve the physicochemical properties of involved drugs. The comparative evaluation of...
Alzheimer's disease (AD) and diabetes are clinically positively correlated. However, the connection between them is not clarified. Here, using
Purpose: This study aimed to investigate the role of long non-coding RNA (lncRNA) NEAT1 in corneal epithelial wound healing mice. Methods: The central epithelium wild-type (WT), MALAT1 knockout (M-KO), (N-KO), and knockdown (N-KD) mice was scraped evaluate nerve regeneration rates. sequencing from WT N-KO performed 24 hours after debridement determine NEAT1. Quantitative PCR (qPCR) ELISA were used confirm bioinformatic analysis. effects cAMP signaling pathway evaluated N-KD using SQ22536, an...
Ulcerative colitis (UC) is an inflammatory disease that leads to the overexpression of peroxynitrite (ONOO
Abstract We previously described the design of triacetic acid lactone (TAL) biosensor ‘AraC-TAL1’, based on AraC regulatory protein. Although useful as a tool to screen for enhanced TAL biosynthesis, this variant shows elevated background (leaky) expression, poor sensitivity and relaxed inducer specificity, including responsiveness orsellinic (OA). More sensitive biosensors specific either or OA can aid in study engineering polyketide synthases that produce these similar compounds. In work,...
Immunostimulatory CpG ODNs activate an immune response through recognition with TLR9. demonstrate great potential in immunotherapy. However, their application is limited by drawbacks such as rapid nuclease degradation, low cellular uptake, and deficient release TLR9-localized endo/lysosome. Precise transportation of into endo/lysosomes cells crucial for promoting the immunostimulatory effect. In this work, a macrophage-targeted delivery system was fabricated. Yeast β-glucan grafted glycogen...
An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may involved this transformation.
The Escherichia coli regulatory protein AraC regulates expression of ara genes in response to l-arabinose. In efforts develop genetically encoded molecular reporters, we previously engineered an variant that responds the compound triacetic acid lactone (TAL). This (named "AraC-TAL1") was isolated by screening a library variants, which five amino positions ligand-binding pocket were simultaneously randomized. Screening carried out through multiple rounds alternating positive and negative...
Objective Sphingosine-1-phosphate receptor (S1PR) modulators have recently attracted increasing attention for the treatment of multiple sclerosis (MS). Despite their preference in clinic, adverse events (AEs) continue to be reported every year. This study aimed investigate potential AEs as well related important medical (IMEs) signal associated with S1PR modulators, including fingolimod, siponimod and ozanimod a real-world using FDA Adverse Event Reporting System (FAERS) database. Methods...