A5113701338- Chronic Myeloid Leukemia Treatments
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Natural product bioactivities and synthesis
- Chronic Lymphocytic Leukemia Research
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Photodynamic Therapy Research Studies
- Traditional Chinese Medicine Analysis
- Click Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Flavonoids in Medical Research
- Mast cells and histamine
Xiangtan University
2024
The University of Texas MD Anderson Cancer Center
2007-2010
A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The has long emission and large Stokes shift. TX-P can be used to visualize ONOO − in cells, image paw edema mice evaluate anti-inflammatory drugs.
Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a to target drug-resistant mutant kinase constitutes therapeutic challenge. We approach problem by redesigning anticancer imatinib guided local changes in interfacial de-wetting propensities C-Kit introduced an imatinib-resistant mutation. The ligand is redesigned sculpting shifting hydration...
To evaluate the effects of astragaloside on proliferation, invasion, migration and apoptosis nonsmall cell lung cancer A549 cells phosphatidylinositol 3-kinase/protein kinase B/mechanistic target rapamycin pathway. After were treated with 0, 10, 20, 40, 60, 80 100 μmol/l for 24 h, survival rate was measured by methyl thiazolyl tetrazolium assay half maximal inhibitory concentration calculated. Astragaloside at added. Cell detected transwell assay, wound healing flow cytometry, respectively....
7019 Background: Tyrosine kinases (TK) are important for most cellular functions and require stringent control regulation. C- Kit, a TK transmembrane receptor stem cell factor, plays crucial role in hematopoiesis. Mutations of c-Kit can contribute to AML pathophysiology have been associated with shorter survival higher relapse risk following standard therapy. On the other hand, responses observed inhibitor therapy such as imatinib. Identification or its pathways leukemogenesis development...