A5101695921- Metabolism and Genetic Disorders
- Iron Metabolism and Disorders
- Trace Elements in Health
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Neonatal Health and Biochemistry
- Folate and B Vitamins Research
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
- COVID-19 Clinical Research Studies
- Hops Chemistry and Applications
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Heavy Metal Exposure and Toxicity
- Retinal and Optic Conditions
- Invertebrate Immune Response Mechanisms
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- Parkinson's Disease Mechanisms and Treatments
- Biochemical and Molecular Research
- Dermatological and COVID-19 studies
- Horticultural and Viticultural Research
Beijing Obstetrics and Gynecology Hospital
2020-2024
Capital Medical University
2020-2024
Wuhan University
2008-2023
Renmin Hospital of Wuhan University
2020-2023
Tsinghua University
2014-2022
Huazhong University of Science and Technology
2008
Fifth Hospital In Wuhan
2008
The intracellular iron transfer process is not well understood, and the identity of transporter responsible for delivery to secretory compartments remains elusive. In this study, we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills effluxing role. Interfering with dZIP13 expression causes iron-rescuable absorption defect, simultaneous increase in cytosol decrease compartments, failure ferritin loading, abnormal collagen secretion. E. coli confers upon host iron-dependent...
Abstract Background We aimed to evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, treat coronavirus disease 2019 (COVID-19) patients with prolonged postsymptomatic viral shedding. Methods conducted a prospective, randomized controlled, open-label trial involving hospitalized adult COVID-19 polymerase chain reaction (PCR) positivity. Patients were randomly assigned receive either leflunomide (50 mg every 12 hours, 3 consecutive times, orally;...
Abstract Human neurodegenerative disorders often exhibit similar pathologies, suggesting a shared aetiology. Key pathological features of Parkinson’s disease (PD) are also observed in other diseases. Pantothenate Kinase-Associated Neurodegeneration (PKAN) is caused by mutations the human PANK2 gene, which catalyzes initial step de novo CoA synthesis. Here, we show that fumble ( fbl ), homolog Drosophila , interacts with PINK1 genetically. and mutants display mitochondrial abnormalities,...
The Systemic Inflammatory Response Index (SIRI) is a promising inflammatory marker; however, the relationship between SIRI and latent tuberculosis infection (LTBI), as well its association with mortality rates, remains unclear. present study aimed to explore associations of LTBI all-cause mortality. We conducted prospective cohort using data from National Health Nutrition Examination Survey (NHANES) cycles 2011 2012. explored prevalence Multiple logistic regression models. used Multivariate...
Alzheimer's disease (AD) and diabetes are clinically positively correlated. However, the connection between them is not clarified. Here, using
Abstract Background Individual inborn errors of metabolism (IEMs) are rare disorders. Expanded newborn screening for IEMs by tandem mass spectrometry (TMS) is an efficient approach early diagnosis. Here we provide the program application this (between July 2014 and March 2019) to identification newborns in Beijing at risk developing a potentially fatal disease. Methods The amino acids acylcarnitines dried blood spots were analyzed TMS. Diagnoses with elevated metabolites confirmed gas...
To evaluate the efficacy and safety of leflunomide for treatment acute, symptomatic COVID-19.A single-center, open-label, randomized controlled trial was performed during an outbreak SARS-CoV-2 Omicron variant in December 2022. Symptomatic patients within 5 days COVID-19 onset were randomly allocated to receive either with or alone. The primary endpoint time sustained clinical recovery.Fifty-seven participants into two groups: 27 received plus 30 assigned Participants treated had a shorter...
NeoBase 2 Non-derivatized MSMS assay kit (NeoBase kit) was used for newborn screening, the performance of should be validated before its implementation in clinical diagnostic laboratories.
Background: Phenylalanine-restricted diets have been the basis of therapy for phenylketonuria; however, little is known how this treatment effects homeostasis other amino acids. This study aimed to assess blood acid alterations in phenylketonuric neonates before and after identify any residual with phenylalanine restriction these treated children. Methods: Concentrations 11 acids were measured using liquid chromatography-tandem mass spectrometry performed on dried spots. Results: Elevated...
Abstract Background Phe-restricted diets have been the basis of therapy for phenylketonurics; however, little is known how this treatment effects homeostasis other important amino acids. This study aimed to describe blood acid patterns in neonates with phenylketonuria (PKU) and identify any Phe restriction on these young children. Methods Neonate group (age 0–4 weeks): 45 PKU patients, age-/sex-matched controls without PKU; 1–4 year-old group: 27 diet-treated children PKU. Concentrations 11...
Abstract Background Phe-restricted diets have been the basis of therapy for phenylketonurics; however, little is known how this treatment effects homeostasis other important amino acids. This study aimed to describe blood acid patterns in neonates with phenylketonuria (PKU) and identify any Phe restriction on these young children. Methods Neonate group (age 0-4 weeks): 45 PKU patients, age-/sex-matched controls without PKU; 1-4 year-old group: 27 diet-treated children PKU. Concentrations 11...