A5059465475- Microbial Metabolic Engineering and Bioproduction
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Microbial Natural Products and Biosynthesis
- Fungal and yeast genetics research
- Enzyme Structure and Function
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
University of Houston
2020-2022
Abstract We previously described the design of triacetic acid lactone (TAL) biosensor ‘AraC-TAL1’, based on AraC regulatory protein. Although useful as a tool to screen for enhanced TAL biosynthesis, this variant shows elevated background (leaky) expression, poor sensitivity and relaxed inducer specificity, including responsiveness orsellinic (OA). More sensitive biosensors specific either or OA can aid in study engineering polyketide synthases that produce these similar compounds. In work,...
Abstract We previously described the design of triacetic acid lactone (TAL) biosensor “AraC-TAL1”, based on AraC regulatory protein. While useful as a tool to screen for enhanced TAL biosynthesis, this variant shows elevated background (leaky) expression, poor sensitivity, and relaxed inducer specificity, including responsiveness orsellinic (OA). More sensitive biosensors specific either or OA can aid in study engineering polyketide synthases that produce these similar compounds. In work, we...