A5103022304- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- MicroRNA in disease regulation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Immune Response and Inflammation
Shandong University
2014-2023
Shandong Provincial Hospital
2014-2023
Shandong First Medical University
2020-2022
Shandong Center for Disease Control and Prevention
2017-2021
Health Commission of Anhui Province
2018
University of Kentucky
2013
Abstract Background We and others have confirmed activation of macrophages plays a critical role in liver injury fibrogenesis during HBV infection. And we also proved HBeAg can obviously induce the production macrophage inflammatory cytokines compared with HBsAg HBcAg. However, receptor functional domain its effects mechanisms on hepatic fibrosis remain elusive. Methods The potentially direct binding receptors were screened verified by Co-IP assay. Meanwhile, function accessible peptides for...
Sirt6, a member of the mammalian sirtuin family, is protein that located in nucleus and an NAD+‑dependent deacetylase important control metabolic activity genome stability. Recently, several studies have demonstrated potential role Sirt6 tumor biology; however, hepatocellular carcinoma (HCC) remains unclear. In present study, expression was found to be downregulated human HCC tissue compared with adjacent normal tissue. Knockdown promoted growth HepG2 cell line, whereas overexpression...
Intrahepatic cholangiocarcinoma (IHCC) is the second most frequent primary malignant liver tumor following hepatocellular carcinoma. It a highly fatal disease and has few therapeutics. The CXC chemokine ligand-12 (CXCL12)/CXC receptor type 4 (CXCR4) axis been shown to be involved in tumorgenesis, proliferation, angiogenesis variety of cancers including IHCC. However, its prognostic significance IHCC unclear. purpose this study was examine functional role CXCR4 progression metastasis explore...
Aberrant Src kinase activity is known to be involved in a variety of human malignancies, whereas the regulatory mechanism has not been completely clarified. Here, we demonstrated that tripartite motif containing 7 (TRIM7) directly interacted with Src, induced Lys48-linked polyubiquitination and reduced abundance protein hepatocellular carcinoma (HCC) cells. We further identified TRIM7 as tumor suppressor HCC cells through its negative modulation Src-mTORC1-S6K1 axis vivo vitro several...
Systemic inflammation might modulate the microenvironment in lungs and promotes metastasis. E-selectin, an inducible endothelial cell adhesion molecule, has been reported to play important role homing metastatic cancer cells. To study effects of E-selectin expression induced by systemic on breast metastasis, we first treated BALB/c mice with lipopolysaccharide (LPS) induce inflammation. Pulmonary tissues were analyzed wet/dry ratio, hematoxylin eosin (H&E) staining immunohistochemistry. Then...
Objective: To investigate the prognostic value of tumor size in colorectal cancer (CRC) patients with different primary locations. Patients and methods:We retrospectively recruited 3971 stage I-III CRC curative resection.The propensity score matching technique was conducted to reduce selection bias, producing a matched cohort 1347 pairs based on (≤4 cm >4 groups).Kaplan-Meier survival analyses univariate multivariate were used compare overall (OS), cancer-specific (CSS) disease-free (DFS)...
The lung is one of the most frequent target organs for breast cancer metastasis. When cells from a primary tumor do not colonize lung, which we named premetastatic phase, microenvironment has already been influenced by tumor. However, little known about exact alteration and regulatory mechanisms lung. Here, used 4T1 (a mouse cell line can specifically metastasize to lung) build model. We found that induced increased pulmonary vascular permeability in facilitated leakage rhodamine‐dextran...
Introduction: The aim of this study was to compare the effectiveness and safety endoscopic injection sclerotherapy (EIS) with variceal ligation (EVL) in management esophageal bleeding (EVB). Patients Methods: In prospective study, we compared EIS EVL 124 patients who had endoscopically proved from varices. According different treatment methods, they were randomly divided into groups. Sixty-four treated 60 ligation. followed for a mean 2 years, during which determined incidence complications...
Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at clearance of pathogens. In present study, it was demonstrated that macrophage activation by lipopolysaccharide (LPS) or poly(I:C), leading changes cell morphology, differed significantly between mouse line RAW264.7 primary peritoneal macrophages. Moreover, expression α- β-tubulin markedly decreased following LPS...
Abstract The receptor tyrosine kinases (RTKs) family is well-recognized as vital targets for the treatment of hepatocarcinoma cancer (HCC) clinically, whereas survival benefit target therapy sorafenib not satisfactory liver patients due to metastasis. EGFR and MET are two molecules RTK that were related time resistance targeted in clinical reports. However, mechanism therapeutic value EGFR/MET HCC metastasis still completely clarified. study confirmed was highly expressed cells tissues...
Abstract The activation of liver macrophages is closely related to injury after HBV infection. Our previous results demonstrated that HBeAg played a key role in inducing macrophage activation. As we all know, miRNAs are involved the regulation multiple immune cell functions. Meanwhile, have shown miR‐155 positively regulates HBeAg‐induced and accelerates injury. Subsequently, based on our miRNA sequencing results, further evaluated miR‐212‐3p called ‘neurimmiR’ this study. First, expression...
SNAI1, a zinc-finger transcription factor, plays an important role in the induction of epithelial-mesenchymal transition (EMT) various cancers. However, possible functions SNAI1 proliferation and apoptosis hepatocellular carcinoma have not been clearly identified. In this study, we investigated effects mechanisms using clinical samples cell lines. We found that is highly expressed tissues liver cancer compared with adjacent nontumor tissues. also hepatoma lines HepG2, SMMC-7721, BEL-7402...
The aim of this study was to investigate the clinical significance combined fibrinogen and neutrophil-lymphocyte ratio (F-NLR) in patients with resectable colorectal cancer (CRC).We retrospectively recruited 693 stage I-III CRC following curative surgery. Cutoff values preoperative (NLR) were determined receiver operating characteristic analysis. Patients divided into three groups based on F-NLR value further chemotherapy nonchemotherapy groups. overall survival (OS) disease-free (DFS)...
For submucosal tumors (SMTs) originating from the muscularis propria (MP) layer of esophagogastric junction (EGJ), tunneling endoscopic resection (STER) is now widely used, and it shows promise in overcoming limitations dissection.This study aimed to evaluate efficacy safety STER technique for treating SMTs EGJ MP layer.From October 2011 February 2014, 20 patients were enrolled surgery.The categorized into three groups according tumor location. The esophagocardiac group had a lower...