A5102386177- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Hepatitis B Virus Studies
- Child and Adolescent Psychosocial and Emotional Development
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Liver physiology and pathology
- MRI in cancer diagnosis
- Impact of Technology on Adolescents
- Ferroptosis and cancer prognosis
- Pancreatitis Pathology and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Cancer Mechanisms and Therapy
- Child Development and Digital Technology
- Fibroblast Growth Factor Research
- Lipid metabolism and disorders
- Renal cell carcinoma treatment
- Protein Interaction Studies and Fluorescence Analysis
- Pancreatic function and diabetes
- Biliary and Gastrointestinal Fistulas
Shandong Provincial Hospital
2016-2025
Shandong First Medical University
2019-2025
Shanghai Normal University
2023-2024
Shandong University
2016-2023
Shandong Center for Disease Control and Prevention
2016-2021
Human serum albumins (HSAs) are synthesized in the liver and most abundant proteins plasma of healthy human. They play an important role pathophysiological processes even whole organism. Previous studies have mainly focused on regulation HSAs' expression. However, with progress research recent years, it has been found that content circulating albumin cannot fully reflect biological function itself. Given aforementioned fact, concept 'effective concentration' proposed. It refers to is...
We have revealed that neuropilin-1 (NRP-1) promoted hepatic stellate cell activation and liver fibrosis through its profibrogenic signalling pathways. However, the role of NRP-1 in angiogenesis sinusoidal endothelial cells (HSECs) during cirrhosis remains unclear.The correlation between expression was evaluated both human murine cirrhotic tissues by immunohistochemical staining, quantitative real-time PCR, western blotting. In addition, mechanism regulating VEGFR2-dependent identified (ECs)...
Radiofrequency ablation (RFA) is a radical treatment modality for early stage hepatocellular carcinoma (HCC). In addition to direct elimination of tumor cells, RFA induces changes in infiltrating cells within the liver immune microenvironment (TIME), thereby eliciting anti-tumor effects. Moreover, incomplete (IRFA) leads recurrence and metastasis by inducing an immunosuppressive microenvironment. Immunotherapy systemic that enhances anti-tumour responses treat HCC. So, influencing TIME makes...
In recent years, the integration of endoscopic retrograde cholangiopancreatography (ERCP) and cholangioscopy has emerged as a prominent method for managing complex cholelithiasis [1] [2] [3]. We present case demonstrating an innovative effective approach to gallbladder stone extraction via natural lumen ([Video 1]).
With the global epidemic of obesity and diabetes, non-alcoholic fatty liver disease (NAFLD) is becoming most common chronic disease, NASH increasingly a major risk factor for hepatocellular carcinoma. Therefore, it essential to explore novel biomarkers in NASH-related HCC. Deep Learning (DL) methods are promising encouraging tool widely used genomics by automatically applying neural networks (NNs). DL, "limma package", weighted gene co-expression network analysis (WGCNA), Protein-Protein...
Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these portal hypertension (PH) patients has been poorly evaluated.To evaluate diagnosis PH.A total 238 underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze variables associated with PH grade. Then, performances seven indexes, aspartate aminotransferase...
Abstract Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, specific T2D pathogenesis remains largely unexplored. Herein, Tipe1 as key regulator T2D, contributing to maintenance β cell homeostasis is identified. The results show that β‐cell‐specific knockout (termed Ins2‐Tipe1BKO ) aggravated diabetic phenotypes db/db mice or with high‐fat...
Abstract Pathological angiogenesis is an important component of hepatic fibrosis along with fibrous deposition, but its role not well understood. Here, we demonstrated that fibronectin containing extra domain A(FN-EDA), a splice variant highly expressed in fibrosis, mediated disease progression. FN-EDA was positively correlated pathological and reduction expression associated diminished intrahepatic fibrosis. mostly colocalized stellate cells (HSCs) interference or blockage attenuated...
Patients with hepatocellular carcinoma (HCC) surgically resected are at risk of recurrence; however, the factors recurrence remain poorly understood. This study intended to establish a novel machine learning model based on clinical data for predicting early HCC after resection.A total 220 patients who underwent resection were enrolled. Classification models developed predict recurrence. The standard deviation, recall, and precision used assess model's accuracy identify efficiency...
Research Findings: Despite the fact that universal two-child policy had a significant impact on family structure and parenting behaviors, there is still paucity of study mechanisms underlying this policy's effects. This explored role social competence sibling presence in relationship between maternal warmth prosocial behaviors. Participants were 203 children aged 5–6 years (Mage = 48.47 months, SD 3.74;104 boys) their mothers China. Maternal was assessed through observation mother – child...