A5101820752- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Neurological Disease Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Esophageal and GI Pathology
- Traditional Chinese Medicine Analysis
- Protease and Inhibitor Mechanisms
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Tracheal and airway disorders
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- Metabolomics and Mass Spectrometry Studies
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Diaphragmatic Hernia Studies
Nanjing Medical University
2013-2024
University of Yamanashi
2024
Tianjin Chest Hospital
2011-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
City University of Hong Kong
2022
Yangzhou University
2021-2022
Guangzhou University of Chinese Medicine
2016-2020
BACKGROUND:Circular RNA UBE2D2 (circ_UBE2D2) has been found to be involved in the progression of breast cancer. Exosomes are critical mediators intercellular communication, however, function exosomal circ_UBE2D2 cancer remains vague. MATERIAL AND METHODS:Cell viability was measured by Cell Counting Kit-8 assay. Western blot used detect levels estrogen receptor alpha (ERα), E-cadherin, vimentin, CD9, and CD63. Migrated invaded cells were examined using Transwell Circ_UBE2D2 microRNA...
Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder of gastro-intestinal tract, lacking effective drug targets and medications. Caffeic acid phenethyl ester (CAPE), phenolic constituent derived from propolis, has been reported to be potential therapeutic agent for IBD with low water solubility poor bioavailability. In this study, we synthesized new CAPE derivative (FA-97) aimed investigate the effect FA-97 on DSS-induced colitis. Here, found that attenuated body...
Gut microbiota has been implicated in the initiation and progression of various diseases; however, underlying mechanisms remain elusive effective therapeutic strategies are scarce. In this study, we investigated role gut TNBS-induced colitis its associated kidney injury while evaluating potential dietary protein as a intervention. The intrarectal administration TNBS induced mice, concurrently with damage. Interestingly, effect was absent when administered intraperitoneally, indicating...
The UHRF 1 protein is pivotal for DNA methylation and heterochromatin formation, leading to decreased expressions of tumor suppressor genes contributing tumorigenesis. However, the factors that modulate expression in colorectal cancer ( CRC ) remain unclear. Here we showed that, compared with corresponding normal tissues, was upregulated micro RNA ‐9 (miR‐9) downregulated tissues. inversely correlated overall survival rates patients . Overexpression miR‐9 cell lines significantly attenuated...
Sodium Tanshinone IIA sulfonate (STS) is a derivative of (Tan IIA). Tan has been reported to possess neuroprotective effects against Alzheimer’s disease (AD). However, whether STS possesses effect on AD remains unclear. This study aims estimate could protect scopolamine- (SCOP-) induced learning and memory deficit in Kunming mice. Morris water maze results showed that oral administration (10 mg/kg 20 mg/kg) Donepezil shortened escape latency, increased crossing times the original position...
Background: Lung cancer (LC) is the most common malignancy and leading cause of death. LC-derived exosomes have been found to play a critical role in tumor initiation, progression, metastasis drug resistance. Therefore, objective this study identify prognostic markers based on lung cancer-derived patients with different subtypes cancer, including small cell (SCLC), adenocarcinoma (LUAD), squamous carcinoma (LUSC) large (LCC). Additionally, we aim develop corresponding models predict outcomes...
Ligustilide, the main lipophilic component of Radix angelicae sinensis, has been shown to ameliorate cognitive dysfunction in a few Alzheimer’s disease mouse models, but its mechanism is not fully understood. In this study, we employed 7-month-old APP/PS1 mice explore whether LIG able protect against progression. The Morris water maze and Y-maze test results showed that eight weeks intragastric administration (10 mg/kg, 40 mg/kg) every day improved memory deficit mice. thioflavin-S staining...
Background Approximately 8.3–15.9% of patients with clinical stage I non‐small cell lung cancer are subsequently shown to have lymph node metastasis. However, the characteristics metastasis in China not fully understood. Methods This is a multicenter retrospective analysis pathological T1 who underwent surgical resection from 2 January 2014 27 December 2017. Clinical and information was collected assistance Large‐scale Data Analysis Center Cancer Precision Medicine‐LinkDoc database. The...
Hepatocellular carcinoma (HCC) is a lethal malignancy with high rate of metastasis and poor prognosis. There are no effective managements to block HCC. Programmed cell death 4 (PDCD4) found be tumor transformation suppressor. Among investigations on effects PDCD4, little about the metastatic potentials HCC cells. This study was investigate role PDCD4 potential human cells.We examined expression in three lines different potentials, MHCC-97H (high potential), MHCC-97L (low potential) Hep3B (no...
Detection of early neoplastic lesions is crucial for improving the survival rates patients with gastric cancer. Optical enhancement mode 2 a new image-enhanced endoscopic technique that offers bright images and can improve visibility lesions. This study aimed to compare detection optical white-light imaging (WLI) in high-risk population.
The purpose of this study was to screen active components and molecular targets nine prescriptions recommended by the National Health Commission (NHC) China network pharmacology, explore potential mechanism core against COVID-19 with docking.Differentially expressed genes lung adenocarcinoma (LUAD) screened edgeR analysis were overlapped immune-related in MMPORT COVID-19-related GeneCards. also LUAD. TCMSP platform used identify ingredients prescription, identified UniProt database, cross...
Studies have greatly explored the role of microRNAs (miRNAs) in cerebral ischemia/reperfusion injury (CI/RI). But specific mechanism miR-326-5p CI/RI is still elusive. Hence, this study was to unmask miR-326-5p/signal transducer and activator transcription-3 (STAT3) axis CI/RI. Two models (oxygen glucose deprivation [OGD] primary rat cortical neurons middle artery occlusion [MCAO] Sprague-Dawley rats) were established mimic vitro vivo, respectively. Loss- gain-of function assays performed...
Abstract Background Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance role pancreatic ductal adenocarcinoma (PDAC) remains largely unknown. Methods Multiple approaches such as bioinformatic analysis, Transfection, quantitative real-time-PCR, Western blotting, animal studies, RNA-immunoprecipitation (RIP), RNA-pulldown RNA-Fluorescence...