A5041785371- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- Rice Cultivation and Yield Improvement
- Cancer-related gene regulation
- GABA and Rice Research
- Diagnosis and Treatment of Venous Diseases
- Genetics and Plant Breeding
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Procedures and Complications
- Epigenetics and DNA Methylation
- Plant and Biological Electrophysiology Studies
- Genetic and phenotypic traits in livestock
- Plant-Microbe Interactions and Immunity
- Cardiovascular Health and Disease Prevention
- Immunotherapy and Immune Responses
- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- Dermatologic Treatments and Research
- Cardiovascular Disease and Adiposity
- RNA Interference and Gene Delivery
Chengdu University of Traditional Chinese Medicine
2011-2024
Nanjing Medical University
2024
Jianghan University
2019-2023
Wuhan Sixth Hospital
2021-2023
Anhui Agricultural University
2019-2023
Fujian Provincial Hospital
2023
Fujian Medical University
2023
University of Chicago Medical Center
2023
Molecular Oncology (United States)
2023
Jinan University
2022
Recent research advances show that tumor cell intravasation (entry into the circulation) and metastasis occur very early in breast cancer progression. Clinical studies also illustrate potential importance of detection circulating cells (CTCs) outcomes patients with metastatic cancer. Whether these exhibit invasiveness express stem or progenitor markers, hallmark phenotype, is less well characterized. To detect CTCs invasive phenotype to explore their molecular features, we applied a...
Circular RNA (circRNA) are single‐stranded with covalently closed 3′ and 5′ ends, many recognized to be involved in human diseases as gene regulators, typically by interacting other RNA. CircFNDC3B is a circRNA formed back‐splicing of exons 5 6 the FNDC3B gene. was recently implicated renal carcinoma, gastric bladder cancer. However, expression levels circFNDC3B its role colorectal cancer (CRC) remain unclear. Expression TIMP3 CRC tissues cell lines were found low, whereas microRNA...
BACKGROUND:Circular RNA UBE2D2 (circ_UBE2D2) has been found to be involved in the progression of breast cancer. Exosomes are critical mediators intercellular communication, however, function exosomal circ_UBE2D2 cancer remains vague. MATERIAL AND METHODS:Cell viability was measured by Cell Counting Kit-8 assay. Western blot used detect levels estrogen receptor alpha (ERα), E-cadherin, vimentin, CD9, and CD63. Migrated invaded cells were examined using Transwell Circ_UBE2D2 microRNA...
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor entity characterized by early metastasis and late diagnosis. MicroRNA-133b (miR-133b) has been considered as a suppressor in many human cancers regulating epidermal growth factor receptor (EGFR). However, the specific effects of miR-133b EGFR on ESCC remain unclear.qRT-PCR western blotting were applied for measuring expression mRNA protein. Flow cytometry was used detecting cycle apoptosis. Cell proliferation, migration...
Abstract Colorectal cancer (CRC) is the third most frequently diagnosed with unfavorable clinical outcomes worldwide. circFNDC3B plays as a tumor suppressor in CRC, however, mechanism of CRC remains ambiguous. The stem-like properties cells were detected by evaluation stemness markers, sphere formation assay and flow cytometry. qRT-PCR, FISH, IHC, western blotting assessed expression localization circFNDC3B, RNF41, ASB6, markers CRC. metastatic capabilities examined wound healing Transwell...
In this paper, we analyzed medical records of 40 patients with coronavirus disease 2019(COVID-19), in order to explore the clinical efficacy Matrine and Sodium Chloride Injection treatment COVID-19. The investigation was based on results a previous animal test, which aimed investigate confirme test demonstrated that has significant therapeutic effect human pneumonia for model mice. lung inhibition index reached up 86.86%. evaluation conducted confirmed cases COVID-19 treated at Jingzhou...
Hepatocellular carcinoma (HCC) is currently ranked as the third leading cause of cancer-related mortality worldwide. microRNAs (miRs) serve important roles in development and progression HCC. miR-365 has been demonstrated to function a tumor suppressor several types cancer, including HCC; however, mechanisms by which regulates HCC apoptosis remains be elucidated. In present study, reverse transcription-quantitative polymerase chain reaction was performed determine expression levels normal...
Abstract Background Flowering time is an important agronomic trait of crops and significantly affects plant adaptation seed production. varies greatly among maize ( Zea mays ) inbred lines, but the genetic basis this variation not well understood. Here, we report comprehensive architecture six flowering time-related traits using a recombinant line (RIL) population obtained from cross between two genotypes, B73 Abe2, combined with genome-wide association studies to identify candidate genes...
Ovarian cancer (OC) is one of the most lethal malignancies female reproductive system. OC patients are usually diagnosed at advanced stages due to lack early diagnosis. The standard treatment for includes a combination debulking surgery and platinum-taxane chemotherapy, while several targeted therapies have recently been approved maintenance treatment. vast majority relapse with chemoresistant tumors after an initial response. Thus, there unmet clinical need develop new therapeutic agents...
Survivin and transcription factor p65 (NF‑κB p65) participate in the progression of esophageal squamous cell carcinoma (ESCC). However, mechanism NF‑κB activation ESCC remains to be elucidated. The aim present study was investigate role survivin ESCC. expression levels survivin, p65, inhibitor nuclear κB kinase subunit α (IKKα) β (IKKβ) were detected tissue samples. Eca109 KYSE150 cells cultured activity modulated via transfection with an overexpression plasmid, a small hairpin RNA plasmid...
Rice (Oryza sativa L.) appearance quality, which is mainly defined by grain shape and chalkiness, an important target in rice breeding. In this study, we first re-sequenced 137 indica accessions then conducted a genome-wide association study (GWAS) for six agronomic traits with the 2,998,034 derived single nucleotide polymorphisms (SNPs) using best linear unbiased prediction (BLUP) values each trait. The results revealed that 195 SNPs had significant associations traits. Based on linkage...
Abstract Among the many proteases associated with human cancer, seprase or fibroblast activation protein α, a type II transmembrane glycoprotein, has two types of EDTA-resistant protease activities: dipeptidyl peptidase and 170-kDa gelatinase activity. To test if gelatinases could be involved in malignant tumors, we used mammalian expression system to generate soluble recombinant (r-seprase). In presence putative EDTA-sensitive activators, r-seprase was converted into 70- 50-kDa shortened...
Anoikis resistance has been demonstrated to facilitate distant metastases of cancers. MicroRNA-133b (miR-133b) is found be down-regulated in various tumors, including esophageal squamous cell carcinoma (ESCC), and closely correlates with the malignant phenotype ESCC. This study aimed evaluate roles miR-133b ESCC via regulating anoikis.The expression related molecules were detected tissues cells. The target relationship between epidermal growth factor receptor (EGFR) was verified by dual...
Introduction Drought and submergence are contrasting abiotic stresses that often occur in the same rice crop season cause complete failure many rain-fed lowland areas of Asia. Methods To develop varieties with good tolerances to drought submergence, 260 introgression lines (ILs) selected for tolerance (DT) from nine BC 2 populations were screened (ST), resulting 124 ILs significantly improved ST. Results Genetic characterization DNA markers identified 59 DT quantitative trait loci (QTLs) 68...
Glutamate-like receptor (GLR) genes are a group of regulatory involved in many physiological processes plants. With 26 members the rice genome, functionalities most GLR remain unknown. To facilitate their potential uses improvement, an integrated strategy involving CRISPR-Cas9 mediated knockouts, deep mining and analyses transcriptomic responses to different abiotic stresses/hormone treatments gene CDS haplotype (gcHap) diversity 3,010 genomes was taken understand genes, which led us two...
The leaf scorching trait at flowering is a crucial thermosensitive phenotype in maize under high temperature stress (HS), yet the genetic basis of this remains poorly understood. In study, we genotyped 254 RIL-F 2:8 population, derived from scorch-free parental inbred line Abe2 and maternal B73, using specific-locus amplified fragment sequencing (SLAF-seq) method. A total 10,112 polymorphic SLAF markers were developed, high-density map with length 1,475.88 cM was constructed. average depth...