A5032388403- Biochemical and Structural Characterization
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Antimicrobial Peptides and Activities
- Computational Drug Discovery Methods
- Acute Myeloid Leukemia Research
- Microbial Community Ecology and Physiology
- Microplastics and Plastic Pollution
- Abdominal Trauma and Injuries
- Cancer Genomics and Diagnostics
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- Nanoparticles: synthesis and applications
- Gallbladder and Bile Duct Disorders
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Celiac Disease Research and Management
- Protease and Inhibitor Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Appendicitis Diagnosis and Management
- Cancer Risks and Factors
- Cardiac tumors and thrombi
- Blood groups and transfusion
Alberta Health Services
2020-2025
Alzahra University
2013-2024
Northport VA Medical Center
1979-2009
Tarbiat Modares University
2001-2007
Stony Brook University
1979-1992
State University of New York
1979-1989
Albany Medical Center Hospital
1986
Recently, the world has been dealing with a new type of coronavirus called COVID-19 that in terms symptoms is similar to SARS coronavirus. Unfortunately, researchers could not find registered therapy treat infection related virus yet. Regarding fact drug repurposing good strategy for epidemic viral infection, we applied using virtual screening identify therapeutic options COVID-19. For this purpose, five proteins (3-chymotrypsin-like protease (3CLpro), Papain-Like (PLpro), cleavage site, HR1...
To evaluate the potential teratogenicity and mutagenicity of modern cancer treatment, authors enumerated from a cooperative clinical trial group 133 pregnancies in 66 women with malignant neoplasms (53% Hodgkin's disease, 26% other lymphomas leukemia, 21% solid tumors). The gestations were divided into following groups: Group 1, 43 ending before therapy; 2, therapy given at conception or during 32 pregnancies; 3, 58 after therapy. Although total frequencies abnormalities similar Groups 1 2...
Abstract Background The most recent North American pediatric gastroenterology guidelines on diagnosing celiac disease (CD) published in 2016 recommend endoscopic diagnosis (ED) with histologic evaluation as the gold standard all patients. This contrasts European guidelines, which have advocated for a serologic (SD) eligible patients, since 2012. Stollery Children’s Hospital (Edmonton, Alberta), has incorporated SD following internal validation 2016. Until 2020, used an anti-tissue...
Four cases of pure red-cell aplasia (PRCA) in association with chronic lymphocytic leukemia (CLL) are summarized. In addition, all reported CLL-PRCA (27, including our 4 cases) reviewed to consolidate their clinical features and compare them those 26 patients CLL who were anemic (Stage III) 52 not (Stages O-II). The incidence PRCA is about 6%. Eighty-seven percent had B-lymphocyte (B-cell) 13% T-lymphocyte (T-cell) CLL. 17 was the presenting feature, 13 it developed previously diagnosed as...
Aims Cyclotides are mini-proteins that synthesized via the ribosomal pathway. They have a variety of biological activities such as antimicrobial, antitumour, anti-HIV activities. Because their various bioactivities and unique stability, they suitable candidate in drug design applications. The main aim this study was to determine new antimicrobial agents, which can be used instead chemical antibiotics. For reason, we compared effects semipurified cyclotides against human plant pathogenic...
Different approaches have been proved effective for combating the COVID-19 pandemic. Accordingly, in silico drug repurposing strategy, has highly regarded as an accurate computational tool to achieve fast and reliable results. Considering SARS-CoV-2's structural proteins their interaction host's cell-specific receptors, this study investigated a strategy aiming screen compatible inhibitors of FDA-approved drugs against viral entry receptors (ACE2 CD147) integral enzyme polymerase (RdRp).The...
The drying of Iranian seedless white grapes (sultana) was investigated in a batch operation laboratory dryer. effect pretreatment and temperature on the rate at constant air velocity were studied. Pretreatment solutions contained different alkaline materials concentrations temperatures. Dipping an solution increased substantially. Increasing dryer from 60 to 70°C accelerated (for decrease time) pretreated grape. Grapes dried 450–900 min depending temperature. shorter time best quality...
• Postsplenectomy sepsis in children is a well-recognized hazard. Few reports discuss the risk of asplenic adult. Case 47 adults with serious infections following splenectomy for trauma were examined. We conclude that fulminant after Indeed potential and all such patients should receive penicillin prophylaxis pneumococcal vaccine. (<i>Arch Intern Med</i>1984;144:1421-1424)
• All splenectomized individuals are at risk of developing pneumococcal sepsis, but most reports fail to mention how many patients given prophylactic penicillin therapy. Fourteen reported cases postsplenectomy bacterial sepsis in receiving therapy reviewed. In only five cases, the had penicillin-sensitive infection. Hence, exact frequency failure prophylaxis cannot be calculated, it appears very rare. Continuous antibiotic used indefinitely and vaccine both strongly recommended for all...
Bacterial biofilm formation is one of the most critical challenges in industrial and health systems. It leading cause nearly 80 % clinical infections. Biofilms are usually evaluated from physiological point view as microbial cells enclosed an extracellular polymer represent a complex, dynamic bacterial community. Cohesive mechanical forces hold bacteria within together. These contribute to biofilm's structural stability, resulting its viscoelastic properties. Studying properties matter can...
Abstract We describe the characteristics of response to treatment with cyclosporine (CYA) plus prednisone in seven episodes pure red cell aplasia (PRCA) four patients B chronic lymphocytic leukemia (CLL). Fourteen PRCA occurred CLL. Eleven were treated conventional therapies which included an alkylating agent and prednisone. Four that failed respond additional three CYA Six episodes, including had therapies, responded compared six eleven therapies. Response without a reduction leukemic mass....
Abstract Nineteen patients are reported who developed acute myeloblastic leukemia following treatment for a variety of solid tumors, including seminoma (four cases), melanoma (one case), and cancer the ovary (six colon or rectum (three bladder (two cervix, endometrium, larynx case each). There were nine men ten women, with median age 49.8 years (range 29 to 75). The mean interval between diagnosis tumors is 5.8 years. In two diseases occurred simultaneously within six months each other. One...
A 60-year-old man presented with polyarthralgias, a psoriasiform rash, and severe elbow pain. Peripheral blood smear bone marrow biopsy established diagnosis of myelofibrosis myeloid metaplasia. Biopsy the skin lesions revealed nonspecific dermatitis. The clinical presentation was inconsistent psoriatic arthritis, there no evidence for associated gout or collagen-vascular disease. Histological examination tissue taken at time synovectomy indicated arthritis to be due metaplasia involving...
Cyclotides are plant peptides, which characterized by their unique cyclic cysteine knot structure.These peptides have a variety of biological activity including anti-HIV, anti-microbial and cytotoxic effects.In the current study, we compared these gene sequences encoding cyclotides from Viola odorata, V. ignobilis occulta.We also extracted total content fractionation method semipurified on SPE-CI8 (Solid Phase Extraction).Anti-microbial semi-purified was determined radial diffusion assay...