A5056742440- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- MicroRNA in disease regulation
- Organ Donation and Transplantation
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Inflammasome and immune disorders
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2017-2025
China International Science and Technology Cooperation
2017-2025
Tianjin Medical University Cancer Institute and Hospital
2017-2025
Chinese PLA General Hospital
2018-2025
Chinese People's Liberation Army
2025
Shanxi Medical University
2022-2025
Anhui Provincial Hospital
2024
Ningbo Medical Center Lihuili Hospital
2020-2024
Ischemia-reperfusion injury (IRI) has thus far been considered as an inevitable component of organ transplantation, compromising outcomes, and limiting availability. Ischemia-free transplantation is a novel approach designed to avoid IRI, with the potential improve outcomes.
Recent research advances show that tumor cell intravasation (entry into the circulation) and metastasis occur very early in breast cancer progression. Clinical studies also illustrate potential importance of detection circulating cells (CTCs) outcomes patients with metastatic cancer. Whether these exhibit invasiveness express stem or progenitor markers, hallmark phenotype, is less well characterized. To detect CTCs invasive phenotype to explore their molecular features, we applied a...
Ischemia and reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure associated with significant mortality morbidity post-transplantation. We hypothesize that IRI avoidable if the blood supply for not stopped, thus resulting optimal outcomes. Here we described first case of a novel called ischemia-free transplantation (IFOT) patients end-stage liver disease. The graft severe macrovesicular steatosis was donated from 25-year-old man. recipient 51-year-old...
The Vitatex cell-adhesion matrix (CAM) platform allows for isolation of invasive circulating tumor cells (iCTCs). Here we sought to determine the utility prostate-specific membrane antigen (PSMA) as a metastatic castration-resistant prostate cancer (mCRPC) iCTC biomarker, identify solitary and clusters iCTCs expressing either epithelial, mesenchymal, or stem cell markers, explore feasibility epigenomic analysis. CTCs were isolated enumerated simultaneously using CellSearch platforms in 23...
Objective Revealing the single-cell immune ecosystems in true versus de novo hepatocellular carcinoma (HCC) recurrences could help optimal development of immunotherapies. Design We performed 5’and VDJ RNA-sequencing on 34 samples from 20 recurrent HCC patients. Bulk RNA-sequencing, flow cytometry, multiplexed immunofluorescence, and vitro functional analyses were two validation cohorts. Results Analyses mutational profiles evolutionary trajectories paired primary using whole-exome sequencing...
Immune checkpoint inhibitors (ICIs) may lead to rejection and even graft loss of solid organ transplant recipients, making them not widely used in patients. There is insufficient clinical experience using ICIs as a bridging or downstaging therapy before transplantation. We performed retrospective review patients receiving programmed cell death 1 inhibitor (PD1) liver transplantation for HCC our center analyzed the data these with purpose investigating safety feasibility preoperative PD1...
Background and Aims: HBV infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern regulation hepatocyte death during HBV-ACLF progression are still undefined. Evaluating mode cell its inducers will provide new insights for developing therapeutic strategies targeting death. In this study, we aimed to elucidate whether how immune landscapes trigger lead HBV-related ACLF. Approach Results: We identified that pyroptosis represented main in patients with...
Pancreatic cancer (PC) is an extremely malignant tumor with low survival rate. Effective biomarkers and therapeutic targets for PC are lacking. The roles of circular RNAs (circRNAs) in cancers have been explored various studies, however more work needed to understand the functional specific circRNAs. In this study, we explore role mechanism circ_0035435 (termed circCGNL1) PC.
Abstract Dipeptidyl peptidase IV (DPP4/CD26) and seprase/fibroblast activation protein α are homologous type II transmembrane, homodimeric glycoproteins that exhibit unique prolyl activities. Human DPP4 is ubiquitously expressed in epithelial endothelial cells serves multiple functions cleaving the penultimate positioned bonds at NH2 terminus of a variety physiologically important peptides circulation. Recent studies showed linkage between down-regulation certain chemokines mitogenic growth...
In the past 50 years there have been considerable efforts to identify cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that sodium–taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells enterohepatic recirculation) a strong candidate. particular, p.Ser267Phe variation results loss HBV function. We tested role NTCP as for chronic patients using genetic association study....
We tested the association of biologic age (BA) measures constructed from different types biomarkers with mortality and disease in a community-based sample. In Framingham Offspring participants at Exams 7 (1998–2001, mean 62 ± 10) 8 (2005–2008, 67 9), we used Klemera–Doubal method to estimate clinical BA inflammatory computed difference (∆age) between CA. Clinical ∆age was Exam 2 (1979–1983, 45 10). At 8, intrinsic extrinsic epigenetic age. Participants were followed through 2014 for...
Cardiovascular calcification is one of the most severe outcomes associated with cardiovascular disease and often results in significant morbidity mortality. Previous reports indicated that epigenomic regulation microRNAs (miRNAs) might play important roles vascular smooth muscle cell (VSMC) calcification. Here, we identified potential key miRNAs involved vivo investigated role miR-32-5p (miR-32). According to microarray analysis, observed increased expression miR-125b, miR-30a, miR-32...
Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various cancers. The aim this study was to determine prognostic values neutrophil lymphocyte ratio (NLR) and platelet (PLR) patients small cell carcinoma esophagus (SCCE). Preoperative NLR PLR were evaluated 43 SCCE from January 2001 December 2010. significance both markers then determined by uni‐ multivariate analytical methods. Receiver operating characteristic (ROC) curves also plotted...
Protein N-arginine methyltransferases (PRMTs) participate in a number of cellular processes, including cell growth, nuclear/cytoplasmic protein shuttling, differentiation, RNA splicing and post-transcriptional regulation. PRMT2 (also known as HRMT1L1) is clearly involved lung function, the inflammatory response, apoptosis promotion, Wnt signaling leptin regulation through different mechanisms. In this study, we report molecular biological characterization three novel splice variants isolated...
Treponema pallidum ssp. (T. pallidum), the causative agent of sexually transmitted disease syphilis, is an uncultivatable human pathogen. The geographical differences in T. genomes leading to pathogenicity are not yet understood. Presently, twelve available public, all which American origin and often co-infect patients with immunodeficiency virus (HIV). In this study, we examined subsp. strain Amoy, a syphilis pathogen found Xiamen, China. We sequenced its genome using Illumina...
Abstract Gamma-glutamyltransferase (γ-GGT) is a membrane-bound enzyme that involved in biotransformation, nucleic acid metabolism, and tumourigenesis. Elevated serum γ-GGT levels are related to an increased cancer risk worse prognosis many cancers. In the present study, we evaluated prognostic value of preoperative patients with hepatocellular carcinoma (HCC) who underwent liver transplantation (LT). A total 130 HCC after LT were included study. The optimal cut-off was 128U/L by receiver...