A5065419788- dental development and anomalies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- RNA modifications and cancer
- Circular RNAs in diseases
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Bone Metabolism and Diseases
- Oral and Maxillofacial Pathology
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Periodontal Regeneration and Treatments
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- Bone health and treatments
- Selenium in Biological Systems
- Tissue Engineering and Regenerative Medicine
- Nuclear Structure and Function
- Oral microbiology and periodontitis research
- Education and Work Dynamics
- Advanced Frequency and Time Standards
Stomatology Hospital
2016-2025
Sun Yat-sen University
2016-2025
Jiangxi Agricultural University
2025
Hospital of Stomatology, Sun Yat-sen University
2017-2022
Sun Yat-sen Memorial Hospital
2018
Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms characteristic radiation formation are not well-understood. aim this study was to evaluate the direct radiation-induced effects on dental hard tissue investigate their role in caries.Sixty non-carious third molars were divided into three groups (n = 20), which would be exposed 0 Gy, 30 60 Gy radiation, respectively. After microhardness elastic modulus measured at four depths...
Supernumerary tooth-derived pulp stem cells (SNTSCs) hold promise for endodontic regeneration, yet little is known about the similarities and diversities of SNTSCs relative to other dental-derived mesenchymal cells. Herein, we compare biological characteristics with dental (DPSCs) from human exfoliated deciduous teeth (SHED). Cell proliferation, migration, odontogenic differentiation potential, as well viability aging-related phenotype after long-term storage, were evaluated. Additionally,...
In the past 50 years there have been considerable efforts to identify cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that sodium–taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells enterohepatic recirculation) a strong candidate. particular, p.Ser267Phe variation results loss HBV function. We tested role NTCP as for chronic patients using genetic association study....
Graphene oxide (GO), the derivative of graphene with unique properties, has attracted much attention for applications in dental implants. The aim this study was, by two biomimetic cell culture methods, to investigate quantitative relationship between concentration pristine GO nanosheets and their cellular behaviours towards bone marrow-derived mesenchymal stem cells (BMSCs).The were firstly characterized according morphology, self-renewal capabilities multipotency. Subsequently, adhesion...
Accumulating evidence has demonstrated that circular RNAs (circRNAs) play important roles in regulating gene expression involved tumor development. However, the role of circRNAs modulating radiosensitivity oral squamous cell carcinoma (OSCC) and its potential mechanisms have not been documented. We performed high-throughput RNA sequencing (RNA-seq) to investigate circRNA profile OSCC patients discovered circATRNL1 was significantly downregulated closely related progression. The structurally...
Abstract Many circRNA transcriptome data were deposited in public resources, but these show great heterogeneity. Researchers without bioinformatics skills have difficulty investigating invaluable or their own data. Here, we specifically designed circMine (http://hpcc.siat.ac.cn/circmine and http://www.biomedical-web.com/circmine/) that provides 1 821 448 entries formed by 136 871 circRNAs, 87 diseases 120 datasets of 1107 samples across 31 human body sites. further 13 online analytical...
Alveolar bone defect repair remains a persistent clinical challenge for periodontitis treatment. The use of peripheral functional seed cells is hot topic in periodontitis. Herein, we explored the cellular behaviors and osteogenic ability adipose-derived mesenchymal stem (ADSCs) treated with black phosphorus quantum dots (BPQDs). Additionally, macrophage polarization, effects angiogenesis were investigated through paracrine pathway regulated by BPQD-modified ADSCs. Our results demonstrated...
SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter bile acids (BAs) and receptor hepatitis B D viruses. NTCP also target of multiple drugs. We aimed to evaluate medical consequences loss function mutation p.Ser267Phe in SLC10A1. identified eight individuals with homozygous followed up 8-90 months. compared their total serum BAs 6 species 170 wild-type 107 heterozygous healthy individuals. performed in-depth examinations exome...
Many open access transcriptomic data of coronavirus disease 2019 (COVID-19) were generated, they have great heterogeneity and are difficult to analyze. To utilize these invaluable for better understanding COVID-19, additional software should be developed. Especially researchers without bioinformatic skills, a user-friendly platform is mandatory. We developed the COVID19db (http://hpcc.siat.ac.cn/covid19db & http://www.biomedical-web.com/covid19db) that provides 39 930 drug-target-pathway...
Getah virus (GETV) is a mosquito-borne with broad host range, including mosquitoes and various animals such as pigs, horses, goats, cattle, boars, blue foxes. In GETV can cause fever, abortion reproductive disorders in sows, well tremors, diarrhea piglets, posing serious threat to the pig production industry. However, there are few reports on epidemiology of China, reliable diagnostic kits for large-scale detection antibodies lacking. Therefore, this study aimed establish rapid, sensitive...
The scaffold-free cell sheet plays an important role in stem-cell-based regeneration. Graphene oxide (GO) endows nanoparticles (NPs) with special characteristics and therefore has attracted increasing attention recent years. However, the existence of toxicity GO its derivatives limits their ability to promote osteogenic differentiation. Magnetic graphene (MGO), a novel combination Fe3 O4 diverse unique properties, not been studied bone tissue engineering. In this study, MGO was fabricated,...
Hypohidrotic ectodermal dysplasia (HED) is characterized by abnormal development of the teeth, hair, and sweat glands. Ectodysplasin A (EDA), receptor (EDAR), EDAR-associated death domain (EDARADD) are candidate genes for HED, but relationship between WNT10A HED has not yet been validated. In this study, we included patients who presented at least two three features. The four were analyzed in seven PCR Sanger sequencing. Five EDA one EDAR heterozygous mutations identified families 1-6. Two...
Abstract: Both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic tooth agenesis (NSTA) result in symptoms of congenital loss. This study investigated genetic causes two families with XLHED four NSTA. We screened for mutations WNT10A, EDA, EDAR, EDARADD, PAX9, MSX1, AXIN2, LRP6, WNT10B through Sanger sequencing. Whole exome sequencing was performed the proband NSTA Family 4. Novel mutation c.1051G>T (p.Val351Phe) known c.467G>A (p.Arg156His) Ectodysplasin A (EDA) were...
Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription tongue SCC (TSCC) models. Mechanistically, found CISAL directly binds promoter forms an RNA-DNA...
The biological behaviors of magnetic graphene oxide (MGO) in a static field (SMF) are unknown. current study is to investigate the cellular behaviors, osteogenesis and mechanism BMSCs treated with MGO combined an SMF. Results showed that synthetic particles were bio-compatible could significantly improve under SMFs, as verified by elevated alkaline phosphatase activity, mineralized nodule formation, expressions mRNA protein levels. Under SMF at same intensity, addition Fe3O4 increase...
Cleidocranial dysplasia (CCD) is a rare autosomal domi nant skeletal disorder.The typical changes found in CCD patients are short stature, frontal and parietal bos sing, open cranial sutures or the delayed closure thereof, presence of Wormian bones, absent hypoplastic cla vicles, maxilla, iliac wings, brachydactyly.The associated dental anomalies supernumerary teeth, retention primary eruption impaction perma nent dentition.The development teeth rarely affected.Patients generally referred...
X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED NSH. This study investigated the genetic causes six (HED) patients genotype-phenotype correlation.The EDA gene with HED was sequenced. Bioinformatics analysis structural modeling for mutations were performed. The records 134 EDA-related NSH regarding numbers...
While variants of noncoding RNAs (ncRNAs) have been experimentally validated as a new class biomarkers and drug targets, the discovery interpretation relationships between ncRNA human diseases become important challenging. Here we present ncRNAVar (http://www.liwzlab.cn/ncrnavar/), first database that provides association data through manual curation on 2650 publications computational annotation. contains 4565 associations 711 disease phenotypes 3112 from 2597 ncRNAs. Each was reviewed by...
Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies. We hypothesized there was a negative regulation, which might induce apoptosis, between and PUMA adenoid cystic carcinoma (ACC). In this study, expression levels gene after transfection with antisense (As-miR-222) were evaluated by RT-PCR Western blot assays. Cell proliferation migratory abilities detected CCK-8 Transwell cycle...
The Keratinocyte differentiation factor 1 (KDF1) is reported to take part in tooth formation humans, but the dental phenotype of Kdf1 mutant mice has not been understood. Additionally, role KDF1 gene hard tissue development rarely known. In this study, we constructed a missense mutation knock-in mouse model through CRISPR/Cas9 gene-editing technology. Enamel samples from wildtypes (WT) and homozygous mutants (HO) were examined using micro-computed tomography (micro-CT), scanning electron...
Background: Malignant proliferation and cervical lymphatic metastasis restrict the prognosis of oral squamous cell carcinoma (OSCC). Erythropoietin-producing human hepatocellular B4 (EPHB4) regulates a series tumour functions involving tumourigenesis, cancer attachment metastasis. However, mechanism EphB4 regulating malignant progression OSCC has not been fully elucidated. Methods: EPHB4 expression was analysed in 65 samples adjacent noncancerous tissues through immunohistochemistry (IHC)....