A5016474381- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ruminant Nutrition and Digestive Physiology
- Rangeland Management and Livestock Ecology
- GDF15 and Related Biomarkers
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Indigenous Studies and Ecology
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Climate change and permafrost
- Gout, Hyperuricemia, Uric Acid
- interferon and immune responses
- Genomics and Chromatin Dynamics
- Seismic Performance and Analysis
- Polyamine Metabolism and Applications
- Pregnancy and preeclampsia studies
- Demographic Trends and Gender Preferences
- Cancer Cells and Metastasis
- Structural Response to Dynamic Loads
Sun Yat-sen University
2014-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2020-2025
Henan Agricultural University
2022-2023
Nanjing Tech University
2021
Guangzhou Medical University
2017
Abstract Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we report that is overexpressed colorectal (CRC) correlates with prognosis. Conditional Eif3h deletion suppresses AOM/DSS model. Mechanistically, functions as a deubiquitinase for HAX1 stabilizes via antagonizing βTrCP-mediated ubiquitination, which...
In the past 50 years there have been considerable efforts to identify cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that sodium–taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells enterohepatic recirculation) a strong candidate. particular, p.Ser267Phe variation results loss HBV function. We tested role NTCP as for chronic patients using genetic association study....
Chromodomain helicase DNA binding protein (CHD) family plays critical roles in regulating gene transcription. The is linked to cancer disease, but the member's role tumorigenesis remains largely unknown. Here, we report that CHD6 highly expressed colorectal (CRC). knockdown inhibited cell proliferation, migration, invasion, and tumorigenesis. Consistently, Villin-specific Chd6 knockout mice attenuates formation AOM/DSS model. We found aberrant EGF signals promoted stability of by diminishing...
SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter bile acids (BAs) and receptor hepatitis B D viruses. NTCP also target of multiple drugs. We aimed to evaluate medical consequences loss function mutation p.Ser267Phe in SLC10A1. identified eight individuals with homozygous followed up 8-90 months. compared their total serum BAs 6 species 170 wild-type 107 heterozygous healthy individuals. performed in-depth examinations exome...
Introduction The advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms aging AMA remain unclear, posing a significant limitation provide effective guidance for prenatal healthcare clinical settings. Notably, organism shows heightened vulnerability oxidative damage...
Abstract Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators metabolism could provide new approaches improve treatment reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide cancer. Transcriptomic analysis patient samples revealed correlation between expression purine pyrimidine metabolism. A colitis-associated model established that Csn6 intestinal...
Abstract Background Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance expansion in colorectal cancer (CRC) remains poorly characterised. Methods The role COP9 signalosome subunit 6 (CSN6) regulating stemness was evaluated by organoid formation limited dilution analysis. CSN6–TRIM21–OCT1–ALDH1A1 axis vitro vivo. association CSN6, TRIM21 ALDH1A1 expression validated a tissue microarray with 267 CRC...
Abstract Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a metabolic hallmark termed as UC dysregulation. Polyamines are synthesized from ornithine, and polyamine synthetic genes elevated various tumors. However, the underlying deregulations UC/ synthesis cancer remain elusive. Here, we characterized hypoxia-induced lncRNA LVBU (lncRNA regulation via BCL6/urea cycle) that is highly expressed colorectal (CRC) correlates with poor prognosis. Increased promoted...
Abstract Numerous studies have demonstrated that individual proteins can moonlight. Eukaryotic Initiation translation factor 3, f subunit (eIF3f) is involved in critical biological functions; however, its role independent of protein regulating colorectal cancer (CRC) not characterized. Here, it eIF3f upregulated CRC tumor tissues and both Wnt EGF signaling pathways are participating eIF3f's oncogenic impact on targeting phosphoglycerate dehydrogenase (PHGDH) during development....
Abstract Freestanding nonstructural objects are very common in various infrastructure systems, but their dynamic properties with variations the center of gravity (CG) not yet fully understood. To investigate a freestanding object as its CG is varied, steel frame model was fabricated using movable plates. Two scenarios, varying and fixed CG, were considered free rocking tests. The experimental rotation responses generally matched analytical initial cycles, discrepancy increased height ( h cg...
Previous studies have discussed the effects of grazing and house feeding on yaks during cold season when forage is in short supply, but there limited information these strategies Jersey cows introduced to Tibetan Plateau. The objective this study was use genomics metabolomics analyses examine changes rumen microbiology organism metabolism with different strategies.We selected 12 similar body conditions kept them for 60 days under (n = 6) house-feeding conditions. At end experiment, samples...
<div>Abstract<p>Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators metabolism could provide new approaches improve treatment reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide cancer. Transcriptomic analysis patient samples revealed correlation between expression purine pyrimidine metabolism. A colitis-associated model established that...
<p>Table S3</p>
<p>Table S1</p>
<div>Abstract<p>Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators metabolism could provide new approaches improve treatment reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide cancer. Transcriptomic analysis patient samples revealed correlation between expression purine pyrimidine metabolism. A colitis-associated model established that...
<p>Table S4</p>
<p>Supplementary Materials and Methods; Supplementary Figure S1-S11</p>
<p>Table S2</p>
<p>Table S3</p>
<p>Table S2</p>
<p>Table S1</p>
<p>Supplementary Materials and Methods; Supplementary Figure S1-S11</p>
<p>Table S4</p>