A5102934149- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- COVID-19 diagnosis using AI
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Fetal and Pediatric Neurological Disorders
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Autopsy Techniques and Outcomes
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
South China University of Technology
2020-2024
Yangzhou University
2023
Shanghai Jiao Tong University
2023
Key Laboratory of Guangdong Province
2021-2022
Sun Yat-sen Memorial Hospital
2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Third Affiliated Hospital of Sun Yat-sen University
2020
Stomatology Hospital
2020
Abstract Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating translational and predicts poor cancer prognosis, but the mechanism underlying EIF3H tumorigenesis remains to be further elucidated. Here, we report that is overexpressed colorectal (CRC) correlates with prognosis. Conditional Eif3h deletion suppresses AOM/DSS model. Mechanistically, functions as a deubiquitinase for HAX1 stabilizes via antagonizing βTrCP-mediated ubiquitination, which...
Corona Virus Disease (COVID-19) has spread globally quickly, and resulted in a large number of causalities medical resources insufficiency many countries. Reverse-transcriptase polymerase chain reaction (RT-PCR) testing is adopted as biopsy tool for confirmation virus infection. However, its accuracy low 60-70%, which inefficient to uncover the infected. In comparison, chest CT been considered prior choice diagnosis monitoring progress COVID-19 Although diagnostic systems based on artificial...
Background There are no established standard colonoscopy surveillance protocols for patients after curative rectal cancer resection. We investigated the predictive factors colorectal neoplasms during colonoscopies to identify who at risk of developing metachronous in residual colorectum. Methods This was a single-center, retrospective study that included with diagnosis carcinoma had undergone resection from October 2012 June 2018. Clinicopathological variables were analyzed by logistic...
Measurement of the width fetal lateral ventricles (LVs) in prenatal ultrasound (US) images is essential for antenatal neuronographic assessment. However, manual measurement LV highly subjective and relies on clinical experience scanners. To deal with this challenge, we propose a computer-aided detection framework automatic LVs two-dimensional US images. First, train deep convolutional network 2,400 to perform pixel-wise segmentation. Then, number pixels per centimeter (PPC), vital parameter...
COVID-19 causes burdens to the ICU. Evidence-based planning and optimal allocation of scarce ICU resources is urgently needed but remains unaddressed. This study aims identify variables test accuracy predict need for admission, death despite care, among survivors, length stay, before patients were admitted Retrospective data from 733 in-patients confirmed with COVD-19 in Wuhan, China, as March 18, 2020. Demographic, clinical laboratory collected analyzed using machine learning build...
The prognostic value of the advanced lung cancer inflammation index (ALI) has been demonstrated in various tumors. However, significance ALI non-metastatic gastric (GC) remains unclear. This study aimed to identify values patients with GC who underwent radical surgical resection.Patients surgery for from January 2008 September 2020 were enrolled this study. preoperative was calculated as follows: body mass × serum albumin/neutrophil lymphocyte ratio. primary outcomes overall survival (OS)...
Survival benefit of neoadjuvant chemotherapy (NAC) for advanced gastric cancer (AGC) is a debatable issue. Studies have shown that the survival NAC dependent on pathological response to drugs. For those who achieve complete (pCR), significantly prolonged prolapsed-free and overall survival. with poor response, yielded no benefit, only toxicity increased risk tumor progression during chemotherapy, which may hinder surgical resection. Thus, predicting pCR great clinical significance can help...
Removal of colorectal polyps during screening could reduce the incidence cancer (CRC). However, there is a lack data on risk factors associated with recurrence polyps, including conventional adenomas and serrated (SPs). This study aimed to determine for their subtypes based characteristics patients polyps. A total 1,165 diagnosed adenoma or SP in Sixth Affiliated Hospital Sun Yat-sen University between January 2013 December 2019 were enrolled this study, 668 cases adenomas, 385 SPs, 112...
Gastric cancer is the fourth most common malignant disease worldwide, with lower one-third gastric type. Distal gastrectomy D2 lymph node dissection was recommended as a standard surgery for distal patients. However, some controversy remains about anastomosis of residual stomach and intestine. The objectives this trial are to test hypothesis that uncut Roux-en-Y can reduce postoperative complications improve nutritional status more effectively than Billroth II in patients after gastrectomy....
According to the 8th edition AJCC staging manual, a least of 16 lymph nodes retrieval (LNRs) is minimal requirement for (LNs) dissection gastric cancer surgery. Previous studies have shown that increasing number LNRs (≥30) prolongs survival selected patients. However, necessity retrieving 30 or more LN stage II patients still under debate.This study aims explore impact on patients.A total 1,177 diagnosed with were enrolled in this study. The clinicopathological parameters and different (<30...
Lymph node metastasis (LNM) is a critical factor in determining the prognosis of gastric cancer (GC), but its underlying mechanism remains unclear. The tumor mutational burden (TMB) has recently been recognized as biomarker for predicting and response to immune checkpoint inhibitors, while mucin 16, cell surface associated (MUC16) frequently mutated GC. This study explored whether MUC16 mutation status with TMB, LNM, patients GC.Somatic data were downloaded from three GC cohorts. TMB values...
Watch and wait strategy is a safe effective alternative to surgery in patients with locally advanced rectal cancer (LARC) who have achieved pathological complete response (pCR) after neoadjuvant therapy (NAT); present restaging methods do not meet clinical needs. This study aimed construct machine learning (ML) model predict pCR preoperatively.LARC received NAT were included generate an extreme gradient boosting-based ML pCR. The group was divided into training set tuning at 7:3 ratio....
Aims To explore compliance with oral nutritional supplementation (ONS) and to identify the risk factors for noncompliance among gastric cancer patients based on health belief model (HBM)Methods This prospective, observational study included at who were prescribed ONS from July September 2020. Demographic factors, clinical ONS-related social variables derived HBM collected. The outcome of interest was ONS, which measured by self-reported intake ONS. Uni- multivariate analyses potential...
<sec><b>Objective</b>Peritoneal dissemination is difficult to diagnose by conventional imaging technologies. We aimed construct a nomogram predict peritoneal in gastric cancer (GC) patients.</sec><sec><b>Methods</b>We retrospectively analyzed 1,112 GC patients Sun Yat-sen University Cancer Center between 2001 and 2010 as the development set 474 from The Sixth Affiliated Hospital, 2016 validation set. clinicopathological variables associated with (GCPD) were analyzed. used logistic regression...
Abstract Background Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD), which still lacks of reliable markers and therapeutic options. Cellular senescence has been considered an important mechanism intestinal fibrosis, but the underlying molecular link remains elusive. Methods Tissues were stained using α-smooth muscle actin (α-SMA), fibronectin, collagen I as myofibroblastic differentiation. was confirmed through Lamin B1 staining, senescence-associated...
To identify independent prognostic factors to be included in a nomogram predict the prognosis of gastric cancer patients with peritoneal dissemination.This is retrospective study on 684 histological diagnosis dissemination from Sun Yat-sen University Cancer Center as development set, and 62 Sixth Affiliated Hospital validation group. Chi-square test Cox regression analysis were used compare clinicopathological variables dissemination. The Harrell's concordance index (C-index) calibration...