Abstract Consumption of dietary ellagitannins (ETs) has been proven to benefit multiple chronic health disorders including cancers and cardiovascular diseases. Urolithins, gut microbiota metabolites derived from ETs, are considered as the molecules responsible for these effects. Previous studies have demonstrated that urolithins exhibit antiproliferative effects on prostate, breast, colon cancers. However, hepatocellular carcinoma (HCC), it remains elusive. Herein, we aim investigate...

Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance multiple solid tumours. However, there is a lack of universal measures CAFs colorectal cancer (CRC). The aim this study was to assess utility fibroblast-related gene signature (FRGS) for predicting patient outcomes reveal its relevant mechanism. GSE39582 dataset, which includes 316 CRC patients who did not receive adjuvant chemotherapy used as discovery cohort identify...

Hpn is a small histidine-rich cytoplasmic protein from Helicobacter pylori and has been recognized as high-risk factor for several cancers including gastric cancer, colorectal MALT lymphoma. However, the relationship between remains elusive. In this study, we discovered that effectively suppressed cell growth induced apoptosis in hepatocellular carcinoma (HCC). A two-dimensional gel electrophoresis mass spectrometry-based comparative proteomics was performed to find molecular targets of HCC...

Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer (CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, digital pathology, and clinical data from multiple datasets CRC patients proposed novel subtype for CRC. Multi-omics was used to analyze biological features, tumor microenvironment, mutation landscape subtypes, well drug sensitivity immunotherapy response. The score constructed better quantify each patient use....

Background: Radiomics refers to the extraction of a large amount image information from medical images, which can provide decision support for clinicians. In this study, we developed and validated radiomics-based nomogram predict prognosis colorectal cancer (CRC). Methods: A total 381 patients with (primary cohort: n = 242; validation 139) were enrolled radiomic features extracted vein phase preoperative computed tomography (CT). The radiomics score was generated by using least absolute...

Removal of colorectal polyps during screening could reduce the incidence cancer (CRC). However, there is a lack data on risk factors associated with recurrence polyps, including conventional adenomas and serrated (SPs). This study aimed to determine for their subtypes based characteristics patients polyps. A total 1,165 diagnosed adenoma or SP in Sixth Affiliated Hospital Sun Yat-sen University between January 2013 December 2019 were enrolled this study, 668 cases adenomas, 385 SPs, 112...

Background: Increasing evidence have depicted that DNA repair-related genes (DRGs) are associated with the prognosis of colorectal cancer (CRC) patients. Thus, aim this study was to evaluate impact gene signature (DRGS) in predicting CRC Method: In study, we retrospectively analyzed expression profiles from six cohorts. A total 1,768 patients complete prognostic information were divided into training cohort (n = 566) and two validation cohorts 624 578, respectively). The LASSO Cox model...

Background: Preoperative and postoperative evaluation of colorectal cancer (CRC) patients is crucial for subsequent treatment guidance. Our study aims to provide a timely rapid assessment the prognosis CRC with deep learning according non-invasive preoperative computed tomography (CT) explore underlying biological explanations. Methods: A total 808 CT (development cohort: n = 426, validation 382) were enrolled in our study. We proposed novel end-to-end Multi-Size Convolutional Neural Network...

Background: Tertiary lymphoid structures (TLSs) exert a crucial role in the tumor microenvironment (TME), impacting development, immune escape, and drug resistance. Nonetheless, heterogeneity of TLSs colorectal cancer (CRC) their impact on prognosis treatment response remain unclear. Methods: The authors collected genome, transcriptome, clinicopathological information, digital pathology images from multiple sources. An unsupervised clustering algorithm was implemented to determine diverse...

Abstract Background Prognosis varies among stage IV colorectal cancer (CRC). Our study aimed to build a robust prognostic nomogram for predicting overall survival (OS) of patients with CRC in order provide evidence individualized treatment. Method We collected the information 16,283 Surveillance, Epidemiology, and End Results (SEER) database then randomized these ratio 7:3 into training cohort an internal validation cohort. In addition, 501 Sixth Affiliated Hospital Sun Yat-sen University...

Abstract Background Debates exist on the treatment decision of stage II/III colorectal cancer (CRC) due to insufficiency current TNM stage‐based risk stratification system. Epithelial–mesenchymal transition (EMT) and tumor microenvironment (TME) have both been linked CRC progression in recent studies. We propose improve prognosis prediction by integrating TME EMT. Methods In total, 2382 patients from seven datasets one in‐house cohort were collected, 1640 with complete survival information...

In the present study, a natural product database of compounds associated with herbs traditionally verified to treat gout/hyperuricemia/arthritis was constructed. 3D-shape and docking-based virtual screening conducted. To identify potential xanthine oxidase (XOD) inhibitors in database, eight commercial availability were identified as high similarity febuxostat (

Background: Hypoxia is associated with a poorer clinical outcome and resistance to chemotherapy in solid tumors; identifying hypoxic-related colorectal cancer (CRC) revealing its mechanism are important. The aim of this study was assess hypoxia signature for predicting prognosis analyze relevant mechanism. Methods: Patients without were selected the identification hypoxia-related genes (HRGs). A total six independent datasets that included 1,877 CRC patients divided into training cohort two...

Purpose: A certain number of early-stage colorectal cancer (CRC) patients suffer tumor recurrence after initial curative resection. In this context, an effective prognostic biomarker model is constantly in need. Autophagy exhibits a dual role tumorigenesis. Our study aims to develop autophagy-related gene (ATG) signature-based on high-throughput data analysis for disease-free survival (DFS) prognosis with stage I/II CRC. Methods: Gene expression profiles and clinical information CRC...

<h3>Background</h3> Colorectal cancer (CRC) is one of the most common malignant tumors with high heterogeneity. An array tumor immune microenvironmental (TIME) characteristics can influence prognosis and outcome immunotherapy for cancer. We herein aim to identify intrinsic immunological molecular subtypes (IMSs) CRC through integrated analysis transcriptome genome. <h3>Methods</h3> 587 patients from The Sixth affiliated hospital, Sun-yet Sen University (SYSU cohort) were included...

e15520 Background: Identifying robust prognostic risk groups of colorectal cancer (CRC) will significantly improve patients’ outcomes. However, CRC has been demonstrated to be molecularly heterogeneous which affected clinical decision-making. Recently, a comprehensive study proposed four consensus molecular subtypes (CMSs) with biological and characterization, but cost-effective assay for prognosis is lacking. To fill this gap, we present supervised framework using deep learning identify CMS...

Abstract Background: α-Fetoprotein-positive colorectal cancer (AFPP-CRC) is a rare type of (CRC), and there have been no comprehensive investigations on prognostic factors AFPP-CRC. The aim this study was to elucidate the Method: During years 2010 2020, 127 CRC patients with preoperative elevated serum AFP level were collected, after excluding diagnosis hepatitis, hepatocirrhosis hepatocarcinoma. AFPP-CRC group matched by 1:2 AFPN(α-Fetoprotein-negative)-CRC propensity score matching (PSM)...

Abstract Background The prognostic significance of primary tumor size in patients with stage IV colorectal cancer (CRC) has not been established. This study aimed to evaluate the value CRC. Methods We retrospectively analyzed data CRC Surveillance, Epidemiology and End Results (SEER) database treated at Sixth Affiliated Hospital Sun Yat-sen University (SYSU). optimal cutoff for was determined using X-Tile program. Multivariable Cox regression analysis were used examine whether an independent...

3543 Background: As important molecules in the CRC tumor microenvironment (TME), long non-coding RNAs (lncRNAs) regulate functions of infiltrating immune cells and sculpt (TIME), resulting difference survival response to immunotherapy among patients. However, challenges remain selecting TIME related lncRNAs (TIME-lncRNAs) prognosis value stratifying patients for immunotherapy. Here, aim our study was develop a TIME-lncRNAs signature provide predictions. Methods: Gene expression profiles...

Long non-coding RNAs (lncRNAs) remodel the tumor immune microenvironment (TIME) by regulating functions of tumor-infiltrating cells. It remains uncertain way that TIME-related lncRNAs (TRLs) influence prognosis and immunotherapy response colorectal cancer (CRC). Aiming at providing survival predictions, a CRC lncRNA signature (TRLs signature) was developed related potential regulatory mechanisms were explored with comprehensive analysis on gene expression profiles from 97 cell lines, 61...