A5051808566- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Diverticular Disease and Complications
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Galectins and Cancer Biology
- DNA Repair Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Cardiac tumors and thrombi
- Microscopic Colitis
- Vascular Malformations Diagnosis and Treatment
Guangdong Academy of Medical Sciences
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Southern Medical University
2025
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2023
Peking Union Medical College Hospital
2016-2023
It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups as "networks". This study aimed develop competing endogenous RNA (ceRNA) network elucidate the role of long non-coding H19 colorectal cancer. Large-scale RNA-seq data was obtained from The Cancer Genome Atlas database. Differentially expressed RNAs were identified by bioinformatics analysis, and constructed. Functional enrichment...
Resistance to neoadjuvant chemotherapy leads poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration therapeutic strategies improve outcomes. Here, we identified a noncanonical role RB1 for modulating chromatin activity contributes oxaliplatin resistance in colorectal (CRC). We demonstrate induces phosphorylation, which is associated with the oxaliplatin-based LARC. Inhibition phosphorylation by CDK4/6 inhibitor results...
Background: Radiomics refers to the extraction of a large amount image information from medical images, which can provide decision support for clinicians. In this study, we developed and validated radiomics-based nomogram predict prognosis colorectal cancer (CRC). Methods: A total 381 patients with (primary cohort: n = 242; validation 139) were enrolled radiomic features extracted vein phase preoperative computed tomography (CT). The radiomics score was generated by using least absolute...
Abstract Background This study aimed to develop a radiogenomic prognostic prediction model for colorectal cancer (CRC) by investigating the biological and clinical relevance of intratumoural heterogeneity. Methods retrospective multi-cohort was conducted in three steps. First, we identified genomic subclones using unsupervised deconvolution analysis. Second, established signatures link radiomic features with subclone compositions an independent dataset containing matched imaging gene...
Our aim was to compare short- and long-term oncological outcomes between laparoscopic open colectomy in T4 colon cancer.We retrospectively analysed of 94 patients who underwent surgery December 2010 2016 for pT4 cancer, with propensity score matching. All were treated curative intent, by either or en bloc resection.The conversion rate the group 17.0%. Blood loss, time flatus postoperative hospitalization significantly less group. Postoperative morbidity mortality within 30 days did not...
Both loop ileostomy (LI) and transverse colostomy (LTC) could achieve absolute fecal diversion have several advantages. This study compared LI LTC following laparoscopic low anterior resection for rectal cancer after neoadjuvant chemoradiotherapy.Between January 2009 December 2016, 186 patients who underwent ostomy were included. All received preoperative chemoradiotherapy. Of these, 77 109 LTC. Demographic characteristics, operative details, complications analyzed.In the period, group...
Background: Increasing evidence have depicted that DNA repair-related genes (DRGs) are associated with the prognosis of colorectal cancer (CRC) patients. Thus, aim this study was to evaluate impact gene signature (DRGS) in predicting CRC Method: In study, we retrospectively analyzed expression profiles from six cohorts. A total 1,768 patients complete prognostic information were divided into training cohort (n = 566) and two validation cohorts 624 578, respectively). The LASSO Cox model...
Abstract Immunotherapy has dramatically changed the landscape of treatment for colorectal cancer (CRC), but currently lack effective predictive biomarker, especially tumors with mismatch repair (MMR) proficiency. The response immunotherapy is associated cell–cell interactions in tumor microenvironment, encompassing processes such as recognition, binding, and adhesion. However, function immunoglobulin superfamily (IGSF) genes immune microenvironment remains uncharacterized. This study...
Background: Preoperative and postoperative evaluation of colorectal cancer (CRC) patients is crucial for subsequent treatment guidance. Our study aims to provide a timely rapid assessment the prognosis CRC with deep learning according non-invasive preoperative computed tomography (CT) explore underlying biological explanations. Methods: A total 808 CT (development cohort: n = 426, validation 382) were enrolled in our study. We proposed novel end-to-end Multi-Size Convolutional Neural Network...
A 68-year-old woman was admitted to the Peking Union Medical College Hospital with a 6-week history of fever undetermined origin. The computed tomography scan revealed space-occupying lesion in ascending colon and colonic endoscopy protrusive initial segment colon, occupying 3/5 lumen. Pathological examination biopsy specimen malignant fibrous histiocytoma (MFH). patient then underwent laparotomy for right hemicolectomy en bloc lymph node dissection. histopathological confirmed diagnosis MFH...
To clarify the molecular mechanisms underlying poor prognosis of right-sided and mucinous colon cancer at proteomic level. A tandem mass tag-proteomics approach was used to identify differentially expressed proteins (DEPs) in carcinoma tissues from different locations with histological types reveal these differences protein In additional, DEPs were analyzed using bioinformatics methods. The proteomics profiles among cancers tumor dramatically distinguished. terms locations, specific may...
Abstract Background Debates exist on the treatment decision of stage II/III colorectal cancer (CRC) due to insufficiency current TNM stage‐based risk stratification system. Epithelial–mesenchymal transition (EMT) and tumor microenvironment (TME) have both been linked CRC progression in recent studies. We propose improve prognosis prediction by integrating TME EMT. Methods In total, 2382 patients from seven datasets one in‐house cohort were collected, 1640 with complete survival information...
Lynch syndrome (LS) is one of the most common familial forms colorectal cancer predisposing with an autosomal dominant mode inheritance. LS caused by germline mutations in DNA mismatch repair (MMR) genes including MSH2, MLH1, MSH6 and PMS2. Clinically, characterized high incidence early-onset as well endometrial, small intestinal urinary tract cancers, usually occur third to fourth decade life. Here we describe a five generation Chinese family clinically diagnosed according Amsterdam II...
Colorectal cancer (CRC) is a heterogeneous disease, and current classification systems are insufficient for stratifying patients with different risks. This study aims to develop generalized, individualized prognostic consensus molecular subtype (CMS)-transcription factors (TFs)-based signature that can predict the prognosis of CRC.We obtained differentially expressed TF target genes between CMS4 other CMS subtypes CRC from The Cancer Genome Atlas (TCGA) database. A multi-dimensional network...
Background: Previous studies have described diversities in biology and prognosis for colon cancer based on whether the primary is right-sided or left-sided. Recently, there an ongoing debate as to tumor location itself represents independent prognostic factor. We aimed evaluate clinicopathologic features survival between (RCC) left-sided (LCC) stage III cancer.
We report on a patient diagnosed with Peutz-Jeghers syndrome (PJS) synchronous rectal cancer who was treated laparoscopic restorative proctocolectomy ileal pouch-anal anastomosis (IPAA).PJS is an autosomal dominant characterized by multiple hamartomatous polyps in the gastrointestinal tract, mucocutaneous pigmentation, and increased risks of nongastrointestinal cancer.This presents 20-year history intermittent bloody stool, pigmentation family PJS, which together led to diagnosis...
Background: Previous studies have described diversities in biology and prognosis for colon cancer based on whether the primary is right-sided or left-sided. Recently, there an ongoing debate as to tumor location itself represents independent prognostic factor. We aimed evaluate clinicopathologic features survival between (RCC) left-sided (LCC) stage III cancer. Methods: performed a retrospective analysis of 175 Chinese patients with histologically proven TNM undergoing curative resection...
Objective To evaluate the prognostic value of log odds positive lymph nodes (LODDS) in stage 3 colorectal cancer (CRC) patients who have undergone curative resection. Methods We performed a retrospective review 175 CRC underwent resection Peking Union Medical College Hospital from 2005 to 2012. Patients were categorized respectively according AJCC/UICC N grade,the metastatic node ratio (LNR),and their LODDS. The relationship between grade,LNR,LODDS,and overall survival (OS) rates...
Total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is the procedure of choice for patients ulcerative colitis (UC) requiring surgery and familial adenomatous polyposis (FAP). Laparoscopic TPC IPAA has been applied since early 2000s demonstrated to be feasible safe. J-pouch a stapled preferred technique its efficiency good long-term functional outcome. The technical aspects laparoscopic are presented in this article.