A5100394298- Ferroptosis and cancer prognosis
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Lipids, and Metabolism
- Silk-based biomaterials and applications
- Inflammatory Bowel Disease
- Cancer, Hypoxia, and Metabolism
- Anorectal Disease Treatments and Outcomes
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
- Esophageal and GI Pathology
- Cancer-related Molecular Pathways
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Hubei University of Automotive Technology
2025
Sun Yat-sen University
2015-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Beijing University of Chinese Medicine
2024
Soochow University
2019
First Affiliated Hospital of Soochow University
2019
Genome Institute of Singapore
2018
Agency for Science, Technology and Research
2018
Abstract BRD4, a Bromodomain and Extraterminal (BET) protein family member, is promising anti-cancer drug target. However, resistance to BET inhibitors targeting BRD4 common in solid tumors. Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces phosphorylation at tyrosine 97/98 colorectal cancer, resulting stabilization due interaction with the deubiquitinase UCHL3. also displays increased binding chromatin but reduced inhibitors,...
Abstract Dysregulation of the cell cycle machinery leads to genomic instability and is a hallmark cancer associated with chemoresistance poor prognosis in colorectal (CRC). Identifying targeting aberrant expected improve current therapies for CRC patients. Here,upregulated polo‐like kinase 1 (PLK1) signaling, accompanied by deregulation cycle‐related pathways identified. It shown that PLK1 signaling correlates recurrence Genetic pharmacological blockade significantly increases sensitivity...
Abstract Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains be fully elucidated. Using CRC clinical samples together with ex vivo CAFs-CRC co-culture models, we found that CAFs induce expression of Leucine Rich Alpha-2-Glycoprotein 1(LRG1) CRC, where it shows markedly higher metastatic tissues compared primary tumors. We further show CAFs-induced LRG1 promotes migration and invasion is concomitant...
Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSCs) for treatment inflammatory bowel disease (IBD) and IBD-induced cancer. However, whether MSCs have ability to suppress or promote tumor development remains controversial. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known play a critical role homing MSCs. In this study, we aimed evaluate CXCR4-overexpressing on tumorigenesis IBD....
Pancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays pivotal role in the development and progression of several types humans. However, function underlying mechanism SQLE PAAD remain unclear.SQLE expression data were downloaded from The Cancer Genome Atlas Genotype-Tissue Expression database. alterations demonstrated based on cBioPortal upstream miRNAs regulating predicted using starBase....
Resistance to neoadjuvant chemotherapy leads poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration therapeutic strategies improve outcomes. Here, we identified a noncanonical role RB1 for modulating chromatin activity contributes oxaliplatin resistance in colorectal (CRC). We demonstrate induces phosphorylation, which is associated with the oxaliplatin-based LARC. Inhibition phosphorylation by CDK4/6 inhibitor results...
Abstract In‐stent restenosis caused by tumor ingrowth is a major problem for patients undergoing stent placement because conventional stents often lack sustainable antitumor capabilities. The aim of this work to develop silk fibroin (SF)‐based nanofibrous membrane that loaded with combined‐therapy drugs using electrospinning technologies, which further coated on polydioxanone (PDO) and used the treatment colorectal cancer (CRC). In order improve effectiveness, combination therapeutic drugs,...
Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance multiple solid tumours. However, there is a lack of universal measures CAFs colorectal cancer (CRC). The aim this study was to assess utility fibroblast-related gene signature (FRGS) for predicting patient outcomes reveal its relevant mechanism. GSE39582 dataset, which includes 316 CRC patients who did not receive adjuvant chemotherapy used as discovery cohort identify...
Colorectal cancer represents the fourth commonest malignancy, and constitutes a major cause of significant morbidity mortality among other diseases. However, chemical therapy is still under development. Angiogenesis plays an important role in colon We developed HMQ18–22 (a novel analog taspine) with aim to target angiogenesis. found that significantly reduced angiogenesis chicken chorioallantoic membrane (CAM) mouse tissue, inhibited cell migration tube formation as well. Then, we verified...
Abstract Despite showing promise against PIK3CA-mutant breast cancers in preclinical studies, PI3K/AKT pathway inhibitors demonstrate limited clinical efficacy as monotherapy. Here, we found that histone H3K27me3 demethylase KDM6B-targeted IGFBP5 expression provides a protective mechanism for inhibitor-induced apoptosis cancer cells. We overexpression of KDM6B and luminal are positively associated with poorer disease outcomes. Mechanistically, promotes by antagonizing EZH2-mediated...
Invasion and metastasis are crucially important factors in the survival of malignant tumors. Epithelial‐mesenchymal transition ( EMT ) is an early step metastatic progression presence cancer stem cells closely related to tumor survival, proliferation, metastasis, recurrence. Herein we report that ectopic overexpression micro RNA 26b (miR‐26b) colorectal CRC cell lines promoted cell‐like phenotypes vitro. Furthermore, miR‐26b directly targeted suppressed multiple suppressors, including...
EZH2 is over-expressed in human colon cancer and closely associated with tumor proliferation, metastasis poor prognosis. Targeting inhibiting may be an effective therapeutic strategy for cancer. 3-Deazaneplanocin A (DZNep), as inhibitor, can suppress cell growth. However, the anti-cancer role of DZNep cells has been rarely studied. In this study, we demonstrate that inhibit growth survival HCT116 by inducing cellular senescence apoptosis. The study provides a novel view mechanisms cells.
Colorectal cancer (CRC) is one of the most common and lethal cancers worldwide. Unc-51-like kinase 1 (ULK1) plays an important role in autophagy, which widely involved human CRC. The aim present study was to investigate clinical prognostic significance expression ULK1 Expression 339 CRC specimens (tumor-node-metastasis stages I-IV) assessed by immunohistochemistry. optimal cutpoint X-tile program, patients were divided into 2 groups high or low levels ULK1, accordingly. Correlation analysis...
The aim of this study was to evaluate the impact preoperative hypoalbuminemia on development intra-abdominal septic complications (IASCs) after primary anastomosis for patients with Crohn's disease (CD).All CD undergoing bowel resection a during period from 2007 2015 were enrolled. association (<30 g/L) risk IASCs assessed using both univariate and multivariate analyses.A total 124 eligible included, 117 (94.4%) whom had available albumin level. Preoperative occurred in 13 (11.7%) patients....
The impact of a patient's gender on the development anastomotic leak (AL) in rectal cancer patients following total mesorectal excision (TME) remains controversial. aim this study was to evaluate association between patients' and risk AL. All TME with primary anastomosis during period from 2010 2014 were examined. Comparisons post-operative AL incidence rate male female performed. Of all examined (n = 956), 587 (61.4%) males 369 (38.6%) females. Male more likely have history smoking drinking...
Kyphoplasty is a novel approach treating osteoporotic vertebral compression fractures and poly(methyl methacrylate) (PMMA) the most common bone cement used for kyphoplasty. Cement leaked into an intervertebral disc (IVD) usually causes problems. Herein, we explored effects of PMMA particles on biological behavior nucleus pulposus cells proved inhibiting effect in dose-dependent manner. Besides, led to cell cycle arrest abnormal expression several apoptosis associated gene. Futhermore, found...