A5052509964- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Autoimmune and Inflammatory Disorders
- Circular RNAs in diseases
- Colorectal Cancer Screening and Detection
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Stoma care and complications
- Inflammasome and immune disorders
- Anorectal Disease Treatments and Outcomes
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Pelvic floor disorders treatments
- Ferroptosis and cancer prognosis
- Immunodeficiency and Autoimmune Disorders
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2024-2025
Xinxiang University
2025
Hangzhou Normal University
2025
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Suzhou Municipal Hospital
2024
Third Xiangya Hospital
2023-2024
Central South University
2023-2024
Sun Yat-sen University Cancer Center
2024
State Key Laboratory of Oncology in South China
2024
Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis colorectal cancer (CRC) remain largely unknown. Besides, tumor-associated macrophages (TAMs) play an important role tumor progression, yet contribution of lncRNA-mediated crosstalk between TAMs and CRC cells to progression not well understood. In this study, we report that lncRNA RPPH1 was significantly upregulated tissues, overexpression associated with...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Conventional treatments for inflammatory bowel disease (IBD) have multiple potential side effects. Therefore, alternative are desperately needed. This work demonstrated that systemic administration of exosomes from human bone marrow–derived mesenchymal stromal cells (MSC-Exos) substantially mitigated colitis in various models IBD. MSC-Exos treatment downregulated responses, maintained intestinal barrier integrity, and polarized M2b macrophages but did not favor fibrosis. Mechanistically,...
Abstract Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with various digestive cancers. However, whether P. can promote colorectal cancer and the underlying mechanism such promotion remains unclear. In this study, we found that was enriched in human feces tissue samples from patients compared those adenoma or healthy subjects. Cohort studies demonstrated infection poor prognosis cancer. increased tumor counts volume ApcMin/+ mouse model growth...
Abstract Mutant KRAS (KRAS MUT ) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from sensitive activation-induced cell death (AICD). circATXN7, an NF-κB-interacting circular RNA, governs sensitivity AICD inactivating NF-κB. Mechanistically, histone lactylation derived cell-produced lactic acid directly activates transcription of which binds NF-κB p65 subunit and...
Abstract Background and Objectives To investigate the expression dynamics of CD73 its prognostic significance in human colorectal cancer (CRC). Methods were detected by Western blotting. Immunohistochemistry was used to examine CRC tissues from two independent cohorts tissue microarrays. The optimal cutpoint assessed X‐tile program. Results blotting analysis demonstrated that significantly higher than normal tissues. According program, for high determined when index more 5.9. High observed...
Purpose: Although many biological processes are involved in the modification of N6-methyladenosine (m6A), exact role m6A development malignant tumors remains unclear. Methyltransferase 3 (METTL3) is a major RNA methyltransferase. We aimed to explore METTL3 colorectal cancer (CRC) carcinogenesis and disease progression. Methods: In this study, immunohistochemistry was performed with tissue microarray. qRT-PCR Western blots were used evaluate expression CRC cells. The effect on cell...
Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its regulating immune-unrelated biological processes such as proliferation and metastasis remains unclear. We seek to explore immune-independent functions colorectal cancer (CRC). Methods: The expression CRC was determined by immunohistochemistry. effect signaling on cell evaluated vitro vivo. RNA sequencing analysis performed identify pivotal pathways modulated CD47. interaction between ENO1 verified...
Abstract Background Constitutive activation of nuclear factor-κB (NF-κB) signaling plays a key role in the development and progression colorectal carcinoma (CRC). However, underlying mechanisms excessive NF-κB remain largely unknown. Methods We used high throughput RNA sequencing to identify differentially expressed circular RNAs (circRNAs) between normal human intestinal epithelial cell lines CRC lines. The identification protein encoded by circPLCE1 was performed using LC–MS. function...
Abstract Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate cell-extrinsic role KRAS, where engages with the tumor microenvironment by functional reprogramming tumor-associated macrophages (TAMs). In human CRC specimens, mutant positively correlates presence TAMs. Mutationally activated cells reprograms TAM-like phenotype via combination effect tumor-derived CSF2 and lactate....
The tumorigenesis of colorectal cancer (CRC) often follows the normal-adenoma-carcinoma (N-A-C) sequence. However, molecular mechanisms underlying adenoma carcinogenesis remain largely unknown. Here, we analyzed transcriptomic profile changes in normal, advanced adenoma, and carcinoma tissues from patients with CRC, revealing that glutamic-pyruvic transaminase 1 ( GPT1 ) was down-regulated during N-A-C process correlated poor CRC prognosis. Mechanistically, transcriptionally activated by...
Abstract Background Tumour immune macroenvironment is comprised of tumour and surrounding organs responding to tumourigenesis immunotherapy. The lack comprehensive analytical methods hinders its application for prediction survival treatment response in colorectal cancer (CRC) patients. Methods Cytometry by time‐of‐flight (CyTOF) RNA‐seq was applied characterise cell heterogeneity a discovery cohort including tumour, blood intestinal architecture comprising epithelium, lamina propria,...
Background and aims Nearly half of all patients with inflammatory bowel disease (IBD) use the Internet as a source information for their disease. We analyzed source, content accuracy IBD videos found on YouTube - one most popular websites in United States assessed demographic variables viewers.The 100 viewed relevant were analyzed. included only English language that less than 20 min length primarily focused IBD. Those no sound/poor sound quality excluded. More 30 analyzed.Adults 45-54 years...
Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSCs) for treatment inflammatory bowel disease (IBD) and IBD-induced cancer. However, whether MSCs have ability to suppress or promote tumor development remains controversial. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known play a critical role homing MSCs. In this study, we aimed evaluate CXCR4-overexpressing on tumorigenesis IBD....
Screening for early‐stage disease is vital reducing colorectal cancer (CRC)‐related mortality. Methylation of circulating tumor DNA has been previously used various types screening. A novel cell‐free (cfDNA) methylation‐based model which can improve the early detection CRC warranted. For our study, we collected 313 tissue and 577 plasma samples from patients with CRC, advanced adenoma (AA), non‐AA healthy controls. After quality control, 187 (91 non‐malignant patients, 26 AA 70 CRC) 489...
Despite the concern of within-tumor genetic diversity, this diversity is in fact limited by kinship among cells tumor. Indeed, genomic studies have amply supported 'Nowell dogma' whereby same tumor descend from a single progenitor cell. In parallel, data also suggest that could be >10-fold larger if are multiple origins. We develop an evolutionary hypothesis may often harbor cell clones independent origins, but only one would large enough to detected. To test hypothesis, we search for tumors...
SUMMARY Leaf senescence is a complex process that triggered by many developmental and environmental factors. However, the mechanisms regulating leaf remain unclear. Here, we revealed rice ribulose‐1,5‐bisphosphate carboxylase/oxygenase activase (RCA) promotes onset of basal dark‐induced senescence. RCA was mainly expressed in leaves, its expression level quickly declined under dark conditions. Furthermore, rca mutant plants presented prolonged longevity phenotype dark, whereas overexpression...
This paper systematically combs the intervention paths and therapeutic effects of art therapy for autistic children, collates systematic review literature over past decades, expounds status quo research progress appeals to workers public pay attention attach importance children.
Endoscopy-associated perforation (EAP) is a dreaded adverse event with significant morbidity and even mortality. Whether EAP in patients inflammatory bowel disease (IBD) associated worse outcomes not known. We aimed to assess the frequency of perforations undergoing lower gastrointestinal (GI) endoscopies compare risk factors perforation-associated complications (PAC) IBD those without IBD.In this case-control study, we identified GI from January 2002 June 2011. PAC was defined as...
Abstract Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early detection CRC can significantly reduce its mortality rate. Current method diagnosis relies on the invasive endoscopy. Non-invasive assays including fecal occult blood testing (FOBT) and immunological test (FIT) are compromised by low sensitivity specificity, especially at early stages. Thus, non-invasive accurate approach for screening would be highly desirable. Results A new qPCR-based...
Abstract Background Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect patients’ compliance due the uncomfortable, invasive time-consuming process. In recent decades, methylation profiles blood-based circulating tumor DNA (ctDNA) have shown promising results in early multiple tumors. Here we conducted a study investigate performance ctDNA...