A5103228005- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- RNA Research and Splicing
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Southern Medical University
2014
Nanfang Hospital
2014
Abstract Mutant KRAS (KRAS MUT ) is often exploited by cancers to shape tumor immunity, but the underlying mechanisms are not fully understood. Here we report that tumor-specific cytotoxic T lymphocytes (CTLs) from sensitive activation-induced cell death (AICD). circATXN7, an NF-κB-interacting circular RNA, governs sensitivity AICD inactivating NF-κB. Mechanistically, histone lactylation derived cell-produced lactic acid directly activates transcription of which binds NF-κB p65 subunit and...