A5100631620- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Frailty in Older Adults
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Heart Disease Studies
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Olfactory and Sensory Function Studies
- Cardiac Arrhythmias and Treatments
- Trace Elements in Health
The First Affiliated Hospital, Sun Yat-sen University
2009-2025
Sun Yat-sen University
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Third Affiliated Hospital of Zhengzhou University
2022-2025
Fu Wai Hospital
2022-2024
Shanghai University of Engineering Science
2024
Zhengzhou Children's Hospital
2022-2024
Zhengzhou University
2022-2024
Ningbo University
2024
Capital Medical University
2014-2023
Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal carcinoma (ccRCC).Here, we identify a previously unknown oncogenic role for inactive VHL actively triggering histone lactylation promote ccRCC progression.In patients with ccRCC, positively correlates presence lactylation, high levels indicates poor patient prognosis.Inactive VHL-triggered contributes progression by activating transcription platelet-derived...
China is one of the countries with highest burden stroke. Implementing multidimensional management guidelines will help clinicians practise evidence-based care, improve patient outcomes and alleviate societal burdens. This update 2019 edition provide latest comprehensive recommendations for diagnosis treatment ischaemic cerebrovascular diseases.
The roles of oncogenic KRAS in tumor immune evasion remain poorly understood. Here, mutant is identified as a key driver colorectal cancer (CRC). In human CRC specimens, significant reduction cytotoxic CD8
The tumorigenesis of colorectal cancer (CRC) often follows the normal-adenoma-carcinoma (N-A-C) sequence. However, molecular mechanisms underlying adenoma carcinogenesis remain largely unknown. Here, we analyzed transcriptomic profile changes in normal, advanced adenoma, and carcinoma tissues from patients with CRC, revealing that glutamic-pyruvic transaminase 1 ( GPT1 ) was down-regulated during N-A-C process correlated poor CRC prognosis. Mechanistically, transcriptionally activated by...
We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose deprivation (OGD)/reoxygenation (R)-treated neurons peri-infarct region of mice with middle cerebral artery occlusion (MCAO)/reperfusion (R)-simulated stroke. In this study, the role molecular mechanism IL-17A were further explored under condition. found exogenous addition rmIL-17A remarkably (P<0.001) decreased...
Background Compared with adults normal glucose metabolism, those prediabetes tend to be frail. However, it remains poorly understood whether frailty could identify who are most at risk of adverse outcomes related prediabetes. Objective We aimed systematically evaluate the associations between frailty, a simple health indicator, and risks multiple including incident type 2 diabetes mellitus (T2DM), diabetes-related microvascular disease, cardiovascular disease (CVD), chronic kidney (CKD), eye...
Background and purpose Falling is considered an important public health problem among older people. A recent cross‐sectional study suggested that cognitive frailty (CF) associated with falls. We aimed to explore whether CF a risk factor for falls in population‐based longitudinal study. Methods Using data from the Rugao Longevity Aging Study, physical was assessed according modified Fried's phenotype, 20% of participants lowest scores on Revised Hasegawa Dementia Scale were defined as having...
Regional dietetic cultures were indicated in China, but how dietary patterns geographically varied across China is unknown. Few studies systematically investigated the association of with overweight/obesity and hypertension potential mechanism a national sample. This study included 34,040 adults aged 45 years older from Nutrition Health Surveillance (2015−2017), who had complete outcome data, reliable intakes calorie cooking oils, unchanged diet habits, without diagnosed cancer or...
Sun exposure can cause a range of skin disorders. Skin damage be prevented by following certain sun-protection measures. However, the majority reported studies regarding sun-exposure knowledge and behavior have involved Caucasian populations.A self-administered multiple-choice questionnaire was administered. The consisted 13 questions aimed at evaluating people's knowledge, awareness, protection sun exposure, their sunscreens sunscreen use.A total 623 volunteers were enrolled, including 238...
Background Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors BG-EPVS in patients acute lacunar stroke. Methods We prospectively identified stroke (diameter on DWI ≤ 20mm) from Jan 2011 May 2015. Patients were T2 weighted MRI. Age (± 1 year) sex matched controls also recruited same population (two one case)....
Chronic kidney disease (CKD) is prevalent in older adults. In the aging CKD population, cognitive frailty more common, but its prevalence and associated risk factors need to be further investigated.This a cross-sectional study that enrolled patients aged ≥ 60 years with diagnosis of from January 2018 February 2021. Patients were assessed for cognition FRAIL Mini-Mental State Examination (MMSE) scales divided into non-cognitive groups. Risk identified by univariate multivariate logistic...
Enhancement of protein synthesis from mRNA translation is one the key steps supporting cardiomyocyte hypertrophy during cardiac remodeling. The methyltransferase-like5 (METTL5), which catalyzes m6A modification 18S rRNA at position A1832, has been shown to regulate efficiency differentiation ES cells and growth cancer cells. It remains unknown whether how METTL5 regulates hypertrophy. In this study, we have generated a mouse model, METTL5-cKO, with cardiac-specific depletion in vivo. Loss...
The stress hyperglycemia ratio (SHR) was developed to reduce the effects of long-term chronic glycemic factors on levels, which associated with adverse clinical outcomes. This study aims evaluate relationship between postoperative SHR index and all-cause mortality in patients undergoing cardiac surgery. Data for this were extracted from Medical Information Mart Intensive Care IV (MIMIC-IV) database. Patients categorized into four groups based quartiles. primary outcome 30-day mortality,...
Problem-Based Learning (PBL) is an engaging, student-centered teaching approach that has become increasingly popular in the field of medical education. Particularly during clinical rotations, PBL thought to enhance students' reasoning and skills. However, impact pediatric clerkships not been fully explored. This study aimed assess influence on skills interns comparing outcomes between traditional methods. A randomized controlled trial was conducted with 72 (38 male, 34 female) participating...
Environmental access to exercise opportunities plays a crucial role in determining the level of physical activity within population. However, it is unclear how environmental factors contribute disparities and health outcomes. We explored associations between county-level cardiovascular disease (CVD) mortality across US counties. conducted an ecological analysis using aggregated data from two primary sources: County Health Rankings Roadmaps CDC WONDER data. compared age-adjusted CVD quartiles...