A5055920702- Gut microbiota and health
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Advanced Glycation End Products research
- Protein Interaction Studies and Fluorescence Analysis
- T-cell and B-cell Immunology
- Diverticular Disease and Complications
- S100 Proteins and Annexins
- Microscopic Colitis
- Salivary Gland Disorders and Functions
- Dietary Effects on Health
- Digestive system and related health
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Thyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Oral microbiology and periodontitis research
- Iron Metabolism and Disorders
Shandong Provincial Hospital
2019-2023
Shandong First Medical University
2022-2023
Shandong University
2019-2021
Shandong Academy of Chinese Medicine
2020
Qilu Hospital of Shandong University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Rationale: High-salt diet is one of the most important risk factors for hypertension. Intestinal flora has been reported to be associated with high salt–induced hypertension (hSIH). However, detailed roles intestinal in hSIH pathogenesis have not yet fully elucidated. Objective: To reveal and mechanisms development. Methods Results: The abovementioned issues were investigated using various techniques including 16S rRNA gene sequencing, untargeted metabolomics, selective bacterial culture,...
Graves' disease (GD) is a typical organ-specific autoimmune disease. Intestinal flora plays pivotal role in immune homeostasis and development. However, the association mechanism between intestinal GD remain elusive.To investigate GD.We recruited 58 initially untreated patients 63 healthy individuals study. The composition metabolic characteristics of causal relationship pathogenesis were assessed using 16S rRNA gene sequencing, targeted/untargeted metabolomics, fecal microbiota...
Background Previous studies have shown that the gut microbiome is associated with thyroid diseases, including Graves' disease, Hashimoto's nodules, and cancer. However, association between intestinal flora primary hypothyroidism remains elusive. We aimed to characterize in patients. Methods Fifty-two patients 40 healthy controls were recruited. The differences microbiota two groups analyzed by 16S rRNA sequencing technology. Fecal transplantation (FMT) was performed mice using from both...
Chronic kidney disease (CKD) is a universal chronic in China. The balance of the gut microbiome highly crucial for healthy human body, especially immune system. However, relationship between and CKD has not yet been clarified. A total 122 patients were recruited this study. Among them, 24 diagnosed with CKD5 but did receive hemodialysis therapy, 29 received therapy 69 matched controls. composition was analyzed by 16S rRNA (16S ribosomal RNA) gene-based sequencing protocol. High-performance...
Long-term hyperglycemia in patients with diabetes leads to human serum albumin (HSA) glycation, which may impair HSA function as a transport protein and affect the therapeutic efficacy of anticoagulants diabetes. In this study, novel mass spectrometry approach was developed reveal differences profiles glycation sites between healthy subjects. K199 site most significantly changed diabetes, contributing different interactions glycated normal two types anticoagulant drugs, heparin warfarin. An...
Renal anemia is caused by end-stage renal disease (ESRD) but has a complex etiology. The application of dietary fiber (DF) to regulate the gut microbiota shown effective therapeutic effects in some diseases, its role not clear. aim this study was explore effect DF on regulating and metabolite, short-chain fatty acids (SCFAs).A total 162 ESRD patients were enrolled randomly distributed into or control group (received oral potato starch, 10 g/day for 8 weeks). Hemoglobin (Hb), serum iron...
Increasing evidence has linked the thyroid dysfunction to pathogenesis of dementia. Evidence from clinical studies demonstrated that hypothyroidism is related an increased risk But association hyperthyroidism with dementia largely unknown.We used adenovirus containing thyrotropin receptor (TSHR) amino acid residues 1-289 (Ad-TSHR289)-induced Graves' disease (GD) phenotype in Alzheimer's (AD) model mice (APP/PS1 mice) evaluate effect on cognitive function and β-amyloid (Aβ) accumulation.GD...
MiRNAs are a class of small non-coding RNAs with ability to regulate function Treg cells and involved in many autoimmune diseases. Our previous study found that miR-363-5p expression was significantly upregulated peripheral GD patients. Herein, we aimed investigate its effect mechanism on cell dysfunction The results showed upregulation associated the inflammatory factors levels Transcriptome sequencing revealed 883 genes were regulated by cells. These significant differential primarily...