A5027812430- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Genetic Neurodegenerative Diseases
- Congenital Heart Disease Studies
- Congenital heart defects research
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Insect and Pesticide Research
- Escherichia coli research studies
- Neural and Behavioral Psychology Studies
- Neurological Disease Mechanisms and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Amyotrophic Lateral Sclerosis Research
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Disease and Adiposity
- Sphingolipid Metabolism and Signaling
- RNA regulation and disease
- Optical Imaging and Spectroscopy Techniques
- Entomopathogenic Microorganisms in Pest Control
- Nerve injury and regeneration
- Vitamin C and Antioxidants Research
Southwest University
2025
University of Electronic Science and Technology of China
2025
Jiangsu University
2020-2024
Affiliated Hospital of Jiangsu University
2020-2024
HKUST Shenzhen Research Institute
2024
First Affiliated Hospital of Nanchang University
2014-2021
Nanchang University
2014-2021
Chengdu Medical College
2020
Guangdong Medical College
2019
Leshan Normal University
2018
Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that mainly expressed in the intestine and hypothalamus. In recent years, basic clinical studies have shown GLP-1 closely related to lipid metabolism, it can participate metabolism by inhibiting fat synthesis, promoting differentiation, enhancing cholesterol adipose browning. plays key role occurrence development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, atherosclerosis regulating metabolism. It...
Background/aim: Previous studies have suggested that the hepatic steatosis index (HSI) and fatty liver (FLI) can be used as a predictor of non-alcoholic disease (NAFLD).The aim our study was to determine whether non-invasive indices (HSI FLI) are associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM).Methods: This cross-sectional conducted T2DM patients (n=768).Carotid intima-media thickness (CIMT) measured by Color Doppler ultrasound.The HSI calculated based on gender,...
Abstract Previous studies have found inhibitory control differences between obese individuals and those of normal weight. However, some normal-weight with high negative physical self-perception on the fatness subscale show restrictive eating behaviors attentional bias toward high-calorie food, potentially influencing these differences. We collected behavioral electroencephalography data using a novel task. Results showed that exhibited significantly greater restraint behavior compared to...
Background Nodal/TGF-Lefty signaling pathway has important effects at early stages of differentiation human embryonic stem cells in directing them to differentiate into different lineages. LEFTY, one transforming growth factors the pathway, plays an role development heart. The aim this work was find evidence on whether Lefty variations are associated with congenital heart diseases (CHD). Methods We sequenced gene for 230 Chinese Han CHD patients and evaluated SNPs rs2295418, rs360057...
The reason for regeneration in the adult spinal cord during motor neuron degeneration amyotrophic lateral sclerosis (ALS) remains largely unknown. To this end, we studied alteration of vimentin (a neural precursor cells marker CNS)-containing (VCCs) different stages ALS used C57BL/6J G93A SOD1 transgenic mice mimicking ALS. Results showed that VCCs were mostly distributed ependymal zone (EZ) surrounding central canal wild type mice; a few sparsely other regions. However, number significantly...
Abstract Background Bacteria are currently classified into arbitrary species, but whether they actually exist as discrete natural species was unclear. To reveal genomic features that may unambiguously group bacteria genetic clusters, we carried out systematic comparisons among representative bacteria. Results We found of Salmonella formed tight phylogenetic clusters separated by various distances: whereas over 90% the approximately four thousand shared genes had completely identical...
Endogenous ceramide plays an important role in the palmitate (Palm) impairment of proinsulin gene expression pancreatic islet β-cells. Changes liposoluble levels not only depend on metabolic enzymes but also its transport to subcellular sites response Palm stimuli. In this study, we show that suppression protein (CERT) mRNA with small interfering RNA contributed intracellular accumulation chronic exposure and expression, similar effect inhibiting scavenging enzyme sphingomyelin synthase...
Colorectal cancer (CRC) is among the most fatal forms of solid tumor in men and women. While majority diagnosed CRC cases are sporadic, 15‑25% patients have a family history adenomatous polyposis CRC; however, associated gene mutations remain largely unidentified. The aim present study was to investigate genomes four‑generational Chinese Han with familial identify potential genetic anomalies disease. Diagnoses were made by physical enteroscopic examinations all members. Mutational analyses...
Many clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion the simple typical extrapyramidal circuit between striatum and substantia nigra. Therefore, this study aimed to explore new potential damaged pathogenesis other brain regions associated with multiple complex sPD through magnetic resonance imaging (MRI). A total 65 patients mid-stage 35 healthy controls were recruited in study. Cortical structural connectivity was assessed seed-based...
Congenital heart disease (CHD) is a complex illness with high rates of morbidity and mortality. In embryonic development, the first formed organ, which strictly controlled by gene regulatory networks, including transcription factors, signaling pathways, epigenetic factors microRNAs. Bone morphogenetic protein (BMP)-2 -4 are essential in cardiogenesis as they can induce expression NKX2‑5 GATA binding 4, important development heart. The inhibition BMP‑2 ‑4 inhibits late NKX2-5 affects cardiac...
Cucurbitacin B, a triterpenoid compound found in many Cucurbitaceae species, possesses significant antioxidant and anti-inflammatory activity. This research aims to determine the effects of B experimental periodontitis model. Experimental were induced Sprague Dawley rats by ligature method. Silk suture (4/0) was ligated subgingivally around mandibular right first molars placed position for 11 days. The treatment group animals administered (12.5 mg, 25 50 mg/kg bwt) via oral gavage 12 days...
Acquisition of exogenous genetic material is a key event in bacterial speciation. It seems reasonable to assume that recombination the incoming DNA into genome would be more efficient with higher levels relatedness between donor and recipient. If so, speciation smooth process, leading continuous spectrum genomic divergence bacteria, which, however, not case as shown by recent findings. The goal this study was todetermine if transfer efficiency correlated sequence identity.To compare relative...
Many symptoms of sporadic Parkinson's disease (sPD) can't be completely explained by the lesion simple typical extrapyramidal circuit between striatum and substantia nigra. Therefore, we investigated alteration cortical volume, thickness, surface, density in intermediate sPD from Han population Mainland China order to find new pathological brain regions associated with complex clinical manifestations sPD. The surface were examined using voxel-based morphometry corticometry on magnetic...
BCa is the most common cancer of urinary system. TPH1 has been reported to be associated with distinct tumorigenesis. However, role in remains clarified.
Fufenozide was a novel pesticide for the control of Lepidoptera pests, which highly toxic to silkworm. Fufenozide-contaminated soil samples were collected and bacteria that degrade fufenozide isolated screened by selective medium. The colony characteristics, cell characteristics degradation in different concentrations degrading studied. results indicated seven strains degradeing bacteria, named as DDH01, DDH03, DDH04, DDH05, DDH07 respectively, from contaminated with fufenozide. DDH02, DDH04...
Abstract Bcakground: This study was to investigate the clinical characteristics and prognosis of COVID-19 patients combined with or without major chronic diseases like diabetes, hypertension coronary. Methods: We retrospectively analyzed 183 diagnosed at First People's Hospital Jiangxia District (FPHJD) in Wuhan, China attended by Affiliated Jiangsu University supporting medical team from February 1, 2020 March 15, 2020. Patients were divided into simple group(n=134), coronary group(n=49)....