A5101486163- Salmonella and Campylobacter epidemiology
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Cancer Research and Treatments
- Viral gastroenteritis research and epidemiology
- Bacterial Genetics and Biotechnology
- Ginseng Biological Effects and Applications
- Mast cells and histamine
- Metabolomics and Mass Spectrometry Studies
- Machine Learning in Bioinformatics
- Evolution and Genetic Dynamics
- Cancer, Lipids, and Metabolism
- Legume Nitrogen Fixing Symbiosis
- Biochemical Analysis and Sensing Techniques
- Sensory Analysis and Statistical Methods
- Asthma and respiratory diseases
- Yersinia bacterium, plague, ectoparasites research
- Metabolism, Diabetes, and Cancer
- Microbial Metabolites in Food Biotechnology
- Food Allergy and Anaphylaxis Research
- Glycosylation and Glycoproteins Research
Harbin Medical University
2012-2025
Gansu Provincial Maternal and Child Health Hospital
2025
Heilongjiang Academy of Sciences
2023
Genomics (United Kingdom)
2022
China Agricultural University
2021-2022
Shandong University of Traditional Chinese Medicine
2011-2022
The First People’s Hospital of Lianyungang
2020-2022
Xian Yang Central Hospital
2020-2022
Third Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2021
Many lines of evidence demonstrate the associations colorectal cancer (CRC) with intestinal microbial dysbiosis. Recent reports have suggested that maintaining homeostasis microbiota and host might be beneficial to CRC patients, but underlying mechanisms remain unclear. In this study, we established a mouse model dysbiosis evaluated effects fecal transplantation (FMT) on progression. Azomethane dextran sodium sulfate were used induce in mice. Intestinal microbes from healthy mice transferred...
Antiretroviral drugs are essential for preventing mother-to-child transmission (MTCT) of HIV in HIV-infected pregnant women. However, ART treatment women with multidrug resistance remains a major challenge. Effective and safe regimens MTCT should be tailored to this special population. Albuvirtide (ABT) is along-acting fusion inhibitor proven efficacy safety adults multidrug-resistant HIV. Herein, the first time, we report use an ABT-based regimen infected A 25-year-old female patient...
Patients with breast cancer (BC) who benefit from the PD-1/PD-L1 inhibitor (PDi) is limited, necessitating novel strategies to improve immunotherapy efficacy of BC. Here we aimed investigate inhibitory effects flaxseed lignans (FL) on biological behaviors BC and evaluate roles FL in enhancing anticancer PDi. HPLC was used detect content enterolactone (ENL), bacterial transformation product FL. Transcript sequencing performed identified CD38 as a downstream target gene ENL....
Background Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., typhi and S. paratyphi C, typhoid, potentially fatal systemic infection. It is not known whether the typhoid agents have evolved from common ancestor (by divergent processes) or acquired similar pathogenic traits independently convergent processes). Comparison of different with non-typhoidal lineages will provide excellent models for studies on how pathogens might evolved....
In this study, we investigated the dynamics of microbial community and flavor metabolites during traditional fermentation
Abstract Background The effects of enterolignans, e.g., enterodiol (END) and particularly its oxidation product, enterolactone (ENL), on prevention hormone-dependent diseases, such as osteoporosis, cardiovascular hyperlipemia, breast cancer, colon prostate cancer menopausal syndrome, have attracted much attention. To date, the main way to obtain END ENL is chemical synthesis, which expensive inevitably leads environmental pollution. explore a more economic eco-friendly production method, we...
Salmonella enterica serovar Pullorum is a fowl-adapted bacterial pathogen that causes dysentery (pullorum disease). Host adaptation and special pathogenesis make S. an exceptionally good system for studies of evolution speciation, especially regarding pathogen-host interactions the acquisition pathogenicity. We constructed genome map RKS5078, using I-CeuI, XbaI, AvrII, SpeI Tn10 insertions. Pulsed-field gel electrophoresis was employed to separate large DNA fragments generated by...
Background Salmonella serovars Enteritidis and Gallinarum are closely related, but their host ranges very different: the former is host-promiscuous latter can infect poultry only. Comparison of genomic sequences reveals that has undergone much more extensive degradation than Enteritidis. This phenomenon also been observed in other restricted serovars, such as Typhi Paratyphi A. The serovar be further split into two biovars: Pullorum, which take common cause distinct diseases, with eliciting...
Cancer as a large group of complex diseases is believed to result from the interactions numerous genetic and environmental factors but may develop in people without any known or risks, suggesting existence other powerful influence carcinogenesis process. Much attention has been focused recently on particular members intestinal microbiota for their potential roles promoting carcinogenesis. Here we report identification characterization bacteria that exhibited potent anti-malignancy activities...
Genome plasticity resulting from frequent rearrangement of the bacterial genome is a fascinating but poorly understood phenomenon. First reported in Salmonella typhi, it has been observed only small number serovars, although over 2,500 known serovars are all very closely related. To gain insights into this phenomenon and elucidate its roles evolution, especially those involved formation particular pathogens, we systematically analyzed genomes 127 wild-type S. typhi strains isolated many...
Introduction: This study was conducted to determine the prevalence of serotypes, virulence factors, and antimicrobial resistance patterns Shigella spp. in Beijing, China, from 2004 2011. Methodology: Real-time PCR assays were used detect virulent genes, Kirby-Bauer disk diffusion method evaluate resistance. Results: Among total 1,652 isolates, S. sonnei (57.1%) predominant species, followed by flexneri (42.3%), dysenteriae (0.4%), boydii (0.2%). Nineteen serotypes discovered among strains....
Epithelial ovarian cancer (EOC) is the most common and fatal subtype of malignancies, with no effective therapeutics available. Our previous studies have demonstrated extraordinary suppressive efficacy enterolactone (ENL) on EOC. A chemotherapeutic agent, trabectedin (Trabe), shown to be cancer, especially when combined other therapeutics, such as pegylated liposomal doxorubicin or oxaliplatin. Thrombospondin 1 (THBS1), a kind matrix glycoprotein, plays important roles against development...
Selective activation of Delta-like 1 (DLL1)-Notch signaling is a new approach to activate CD8+ T cell and suppress tumor growth, while the efficacy remains modest. Lentinan (LNT) clinically used immunomodulation agent. Thus, we hypothesized that LNT could improve DLL1. The effects combined with DLL1 on growth were evaluated by curve weight in EO771 breast LAP0297 lung models. impacts immune cells gene expression tissues determined flow cytometry, qPCR. Neutrophil depletion was investigate...
Abstract Background Bacteria are currently classified into arbitrary species, but whether they actually exist as discrete natural species was unclear. To reveal genomic features that may unambiguously group bacteria genetic clusters, we carried out systematic comparisons among representative bacteria. Results We found of Salmonella formed tight phylogenetic clusters separated by various distances: whereas over 90% the approximately four thousand shared genes had completely identical...
The bacterial genus Salmonella encompasses a large number of serotypes that are genetically very similar but biologically quite different, especially in pathogenic properties and host specificity. Serotyping has been used for the classification, identification, epidemiological investigation due to its excellent discriminating power, it cannot distinguish different lineages within polyphyletic serotype. Additionally, few institutions have comprehensive set antisera typing. Therefore various...