A5100600246- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Electrospun Nanofibers in Biomedical Applications
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Plant Molecular Biology Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Plant Reproductive Biology
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Garlic and Onion Studies
- Molecular Biology Techniques and Applications
- Plant Physiology and Cultivation Studies
- Genomics and Phylogenetic Studies
- Protease and Inhibitor Mechanisms
- Cardiac electrophysiology and arrhythmias
- Management of metastatic bone disease
- Genetic Mapping and Diversity in Plants and Animals
- Medical Imaging and Analysis
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Peking Union Medical College Hospital
2023-2025
Institute of Bast Fiber Crops
2019-2025
Chinese Academy of Agricultural Sciences
2019-2025
Wuhan University
2024
Southwest Jiaotong University
2014-2024
Harbin Medical University
2016-2024
Academy of Medical Sciences
2024
Capital Medical University
2010-2024
Beijing Tian Tan Hospital
2010-2024
The accurate mapping of reads that span splice junctions is a critical component all analytic techniques work with RNA-seq data. We introduce second generation detection algorithm, MapSplice, whose focus high sensitivity and specificity in the splices as well CPU memory efficiency. MapSplice can be applied to both short (<75 bp) long (≥75 bp). not dependent on site features or intron length, consequently it detect novel canonical non-canonical splices. leverages quality diversity read...
The fungal family Clavicipitaceae includes plant symbionts and parasites that produce several psychoactive bioprotective alkaloids. grass in the epichloae clade (Epichloë Neotyphodium species), which are extraordinarily diverse both their host interactions alkaloid profiles. Epichloae alkaloids of four distinct classes, all deter insects, some—including infamous ergot alkaloids—have potent effects on mammals. exceptional chemotypic diversity may relate to broad range interactions, whereby...
Ovarian cancer is the third most common in female reproductive organs and epithelial ovarian has highest lethality of all gynecological cancers. Pomegranate fruit juice (PFJ) been shown to inhibit growth several types other than cancer. In this study, we exposed cell line A2780 PFJ two its components (ellagic acid luteolin). MTT wound healing assays demonstrated that three treatments suppressed proliferation migration cells. addition, western blotting ELISA showed expression levels MMP2 MMP9...
The overall success of worldwide mass vaccination in limiting the negative effect COVID-19 pandemics is inevitable, however, recent SARS-CoV-2 variants concern, especially Omicron and its sub-lineages, efficiently evade humoral immunity mounted upon or previous infection. Thus, it an important question whether these variants, vaccines against them, induce anti-viral cellular immunity. Here we show that mRNA vaccine BNT162b2 induces robust protective K18-hACE2 transgenic B-cell deficient...
Surface biofunctional modification of coronary artery stents to prevent thrombosis and restenosis formation, as well accelerate endothelialization, has become a new hot spot. However, bioactive coatings on implants are not yet sufficiently developed for long-term activity, they quickly lose efficiency in vivo finally fail. On the basis novel time-ordered concept biofunctionality vascular stents, heparin/poly l-lysine nanoparticle (NP) was immobilized polydopamine-coated titanium surface,...
Epithelial carcinoma is a subtype of ovarian cancers, with the highest lethality among all cancer subtypes. Hitherto surgical excision combined chemotherapy has been most extensively employed method in clinical treatment. However, disease relapses very frequently, calling for more effective therapies. Mangiferin, natural xanthone glucoside, displayed promising anti-cancer activities by vitro studies, but its therapeutic value epithelial treatment, either vivo or remained to be known. This...
Ovarian cancer has the highest mortality among all gynecological malignancies; currently, no effective therapeutics are available for its treatment. Naringenin been shown to inhibit progression of various cancers, but inhibitory effect on ovarian remains unknown.This study aimed evaluate effects naringenin and elucidate underlying mechanisms.Cancer cell proliferation was detected by counting kit-8 crystal violet assays, migration capability determined wound healing transwell assays. Western...
Epithelial ovarian cancer is among the deadliest gynecological tumors worldwide. Clinical treatment usually consists of surgery and adjuvant chemo- radiotherapies. Due to high rate recurrence rapid development drug resistance, current focus research on finding effective natural products with minimal toxic side effects for treating epithelial tumors. Cannabidiol most abundant cannabinoids has a non-psychoactive effect compared tetrahydrocannabinol, which key advantage clinical application....
The horse, like the majority of animal species, has a limited amount species-specific expressed sequence data available in public databases. As result, structural models for genes defined equine genome are predictions based on ab initio analysis or projection gene structures from other mammalian species. current study used Illumina-based sequencing messenger RNA (RNA-seq) to help refine annotation protein-coding and preliminary assessment expression patterns. Sequencing mRNA eight tissues...
The aims of this study were 1) to establish the standard parameters alignment and total segmental range motion (ROM) cervical spine in asymptomatic population, 2) identify factors that influence ROM alignment.The authors measured 636 lateral, flexion, extension plain radiographs 212 volunteers. relationship between was assessed with simple linear regression. Multivariate regression used determine effect influential on ROM.The mean value for C2-7 21.40° ± 12.15°, 63.59° 15.37°. Sex a...
Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development drug resistance. As a result, this disease has low 5-year survival rates. Estrogen receptor inhibitors were commonly used for treatment, but only 7% to 18% patients respond anti-estrogen therapies. Therefore, more effective therapies inhibit estrogen-related tumors are urgently needed. Recently, phytoestrogens, such as lignans with...
Abstract The rapid re‐endothelialization of the vascular stent surface is desirable for preventing thrombosis or reducing restenosis. Many biological factors that promote behavior endothelial cells have been used modification stents. Vascular growth factor (VEGF), which plays an important role in angiogenesis, induces strong growth. In this study, we investigated different VEGF concentrations (50 to 500 ng/ml) determine optimum concentration biocompatibility. First, VEGF‐loaded...
Ovarian Clear Cell Carcinoma (OCCC) displays distinctive clinical and molecular characteristics confers the worst prognosis among all ovarian carcinoma histotypes when diagnosed at advanced stage because of lack effective therapy. IGF2BP3 is an RNA binding protein that modulates gene expression by posttranscriptional action. In this study, we investigated roles in progression OCCC. We used 328 OCCCs from AOVT (the Alberta Tumor Type study) COEUR Canadian Experimental Unified Resource)...
Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte apoptosis. Oxidative stress suggested to be the major contributor development of DCM. This study was intended evaluate protective effect low molecular weight fucoidan (LMWF) against in diabetic rats. Type 2 goto-kakizaki rats were untreated or treated with LMWF (50 100 mg/kg/day) for three months. The establishment DCM model effects on function evaluated echocardiography isolated heart perfusion....
Garlic is an entirely sterile crop with important value as a vegetable, condiment, and medicine. However, the evolutionary history of garlic remains largely unknown.Here we report comprehensive map genomic variation, consisting amazingly 129.4 million variations. Evolutionary analysis indicates that population diverged at least 100,000 years ago, two groups cultivated in China were domesticated from independent routes. Consequently, 15.0 17.5% genes underwent expression change groups,...
Abstract The garlic bulb comprises several cloves, the swelling growth of which is significantly hindered by accumulation viruses. Herein, we describe a single-cell transcriptomic atlas cloves with virus accumulation, comprised 19 681 high-quality cells representing 11 distinct cell clusters. Cells two clusters, clusters 7 (C7) and (C11), were inferred to be from meristem. Cell trajectory analysis suggested differentiation clove start meristem cells, along pseudo-time paths. Investigation...