A5021079201- Thyroid Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Bone health and treatments
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Asphalt Pavement Performance Evaluation
- Management of metastatic bone disease
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
- Facial Trauma and Fracture Management
- Kruppel-like factors research
- Traditional Chinese Medicine Analysis
- Histiocytic Disorders and Treatments
- Berberine and alkaloids research
- Childhood Cancer Survivors' Quality of Life
- Nausea and vomiting management
- Grouting, Rheology, and Soil Mechanics
- Vascular Malformations and Hemangiomas
- Gastric Cancer Management and Outcomes
- Bioactive Compounds and Antitumor Agents
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Ion Channels and Receptors
- Mangiferin and Mango Extracts
- Vagus Nerve Stimulation Research
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2022-2025
Peking University
2022
Peking University People's Hospital
2022
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
Harbin Medical University
2018-2021
Second Affiliated Hospital of Harbin Medical University
2020-2021
Ministry of Transport
2021
Longgang Central Hospital
2020-2021
Epithelial carcinoma is a subtype of ovarian cancers, with the highest lethality among all cancer subtypes. Hitherto surgical excision combined chemotherapy has been most extensively employed method in clinical treatment. However, disease relapses very frequently, calling for more effective therapies. Mangiferin, natural xanthone glucoside, displayed promising anti-cancer activities by vitro studies, but its therapeutic value epithelial treatment, either vivo or remained to be known. This...
Context: Individual patient prognostication for advanced thyroid cancer (TC) is challenging. Circulating tumor cells (CTCs) have been shown to be a valuable prognostic marker other solid cancers. Objective: We hypothesized that CTCs are present in the blood of patients with TC and their number can predict overall survival (OS). Setting: This prospective study at tertiary hospital. Patients, Interventions, Main Outcome Measures: Initial studies were performed cell lines determine feasibility...
Cryptotanshinone (CTS), a bioactive constituent extracted from Chinese traditional herb Danshen (Salvia miltiorrhiza), demonstrates multiple protective effects against cardiovascular diseases. The present study was designed to explore the of CTS in vitro by cultured adult rat cardiac fibroblasts stimulated with angiotensin II (Ang II) and vivo rats acute myocardial infarction. Our data showed that fibroblasts, attenuated Ang II-induced upregulation fibronectin, connective tissue growth...
Bone metastases (BM) can lead to devastating skeletal-related events (SREs) in cancer patients. Data regarding medullary thyroid carcinoma (MTC) with BM are lacking.We evaluated the natural history of and SREs MTC patients identified by a center tumor registry.The study was conducted at tertiary center.We retrospectively reviewed charts who received care from 1991 2014 characterize SREs.Of 1008 treated, 188 were confirmed have (19%), whom 89% (168 188) had nonosseous distant metastases....
Background A satisfactory animal model of breast cancer metastasizing to bone is unavailable. In this study, we used human stem-like cells and build a novel "human-source" skeletal metastasis. Methods Human cells, the CD44+/CD24-/lower subpopulation, was separated cultured. Before injection with mice were implanted in right or left dorsal flanks. Animals Groups A, B, C injected 1×105, 1×106 parental MDA-MB-231 respectively. positive control group (D) without implantation also cells....
Emerging evidence has indicated the critical role of TRPV4 in diverse human cancers. However, underlying molecular mechanism colon cancer invasiveness is still unknown.Immunohistochemistry staining was used to analyze expression and ZEB1 clinical tissues; Wound healing transwell assays were applied determine cell invasiveness; Western blot explore relation between ZEB1.Colon cells transfected with siRNA against or HC067047 (a selective antagonist), full-length plasmid ZEB1, both, order...
This study employed the diffusion tensor image analysis along perivascular space (DTI-ALPS) index to investigate glymphatic system's involvement in Managing Cancer and Living Meaningfully (CALM) intervention improve chemotherapy-related cognitive impairment (CRCI) breast cancer survivors (BCs). 68 BCs were randomly assigned CALM (34 patients) or care-as-usual (CAU) groups. The Mini-Mental State Examination (MMSE) Prospective Retrospective Memory Questionnaire (PRMQ) calculated for all...
Multiple studies have showed that berberine protects against heart diseases, including obesity-associated cardiomyopathy. However, it is not fully disclosed the potential molecular mechanisms of on controlling cardiac remodeling. Kruppel-like factor (KLF) 4, identified as a critical transcriptional factor, participates in multiple injuries. The present study was to explore whether KLF4 determined cardioprotective benefits dietary-induced obese mice. High fat diet-induced mice were treated...
Multiple endocrine neoplasia type 2 is an autosomal dominant inherited syndrome caused by activating mutations in the RET proto-oncogene. The RETK666N DNA variant was previously reported two isolated medullary thyroid carcinoma (MTC) cases, but no family studies are available, and its oncogenic significance remains unknown.The clinical features, genetic data, information of eight index MTC patients with a germline were assessed.Four probands presented extensive nodal metastasis, one...
This study was to report the experiences on clinical value of noninvasive prenatal testing (NIPT) for screening fetal chromosomal deletions/duplications.We performed a retrospective analysis cohort 20,439 pregnancies undergoing NIPT from March 2017 September 2020 at single center. Patients with positive results deletions or duplications had options invasive diagnostic no further testing. The data were complied all cases deletions/duplications. predictive (PPV) calculated tabulated data.In...
Abstract Colorectal cancer (CRC) is the third most common malignancies in adults. Similar to other solid tumors, CRC cells show increased proliferation and suppressed apoptosis during development progression of disease. Previous studies have shown that a novel tumor oncogene, spermatogenic basic helix-loop-helix transcription factor zip 1 (SPZ1), can promote proliferation. However, it unclear whether SPZ1 plays role suppressing apoptosis, molecular mechanism behind SPZ1’s suppression remains...
Aldosterone, as a major product of renin-angiotensin-aldosterone system (RAAS), determines multiple pathophysiological processes in cardiovascular diseases. The excess inflammatory response is one the key profiles aldosterone-mediated cardiac remodeling. However, potential mechanisms aldosterone/inflammatory signaling were still not fully disclosed. present study aimed to investigate whether TIR-domain-containing adapter-inducing interferon-β (Trif) participated aldosterone-induced...
e17547 Background: CTCs have been shown to be a valuable prognostic marker for breast, colon and prostate cancers. We previously reported that ≥ 5 per tube can detected using the Veridex CellSearch system in blood from subset of patients with metMTC. now update survival data evaluate whether elevated are associated worse Methods: Two 7.5 mL tubes whole were obtained 18 subjects (M:F 9:9) distant metastatic MTC. enumerated by system, which identifies immunomagnetic cell selection EpCAM as...
e17550 Background: CTC enumeration in MPTC with EPCAM assays has been unsuccessful. We used an IFISH assay employing simultaneous analysis of 4 DNA probes derived from copy number variations detected comparative genomic hybridization arrays non-small cell lung cancers (NSCLC) .We believe that these might detect CTCs MPTC, as both and thyroid are foregut differentiate under the influence TTF1/NKX2-1. Patients Methods: BCPAP (PTC line) cells pleural fluid a patient were tested to see if NSCLC...
Left bundle branch pacing / peri–left area (peri-LBBAP) has emerged as a novel strategy in patients with infranodal atrioventricular block (AVB) and left block.1,2 We herein reported an interesting case high-degree AVB. Electrophysiological studies (EPS) revealed antegrade functional infra-His of atrial impulses after premature ventricular beat from the His-Purkinje system presence complete right (RBBB) anterior fascicular (LAFB).Thus, peri-LBBAP was successfully safely performed beyond...
Objective The paper compares the mechanical properties of thermoplastic materials and self-curing resin, provides reference for choosing more suitable material instead resin to make base plate Buccal Multiloop removable appliance. Methods At room temperature 25 ℃, we choose 3 mm hot film diaphragm each 10, measure compare properties, using universal tensile force measuring machine, observe morphology fracture surface under electron microscope. Results The elastic ductility...
Objective To investigate the expressions of ETS2 (E-twenty six 2) in colorectal cancer tissues, analyze relationships between clinic-pathological parameters and expression, evaluate its clinical prognostic value. Methods We collected fresh cancer, paracancerous corresponding normal specimens paraffin adjacent to carcinoma. Real-time fluorescent quantitative PCR immunohistochemistry were used detect mRNA expression protein respectively. Results Our results showed that tissues was...