A5051891645- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- MicroRNA in disease regulation
- Public Health and Nutrition
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Health and Medical Studies
- Delphi Technique in Research
- PI3K/AKT/mTOR signaling in cancer
- Inflammation biomarkers and pathways
- Eosinophilic Esophagitis
- School Health and Nursing Education
- Flavonoids in Medical Research
- Lung Cancer Treatments and Mutations
- Cardiovascular Health and Risk Factors
- Human Health and Disease
- Medicinal Plant Pharmacodynamics Research
- Mitochondrial Function and Pathology
- Pulmonary Hypertension Research and Treatments
- Digital Mental Health Interventions
- Plant-based Medicinal Research
- Health and Lifestyle Studies
- Angiogenesis and VEGF in Cancer
Qinghai Provincial Peoples Hospital
2014-2024
Guangzhou Medical University
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Qinghai No.3 People's Hospital
2017-2023
Immunochemotherapy is the first-line standard for extensive-stage small-cell lung cancer (ES-SCLC). Combining regimen with anti-angiogenesis may improve efficacy. ETER701 was a multicenter, double-blind, randomized, placebo-controlled phase 3 trial that investigated efficacy and safety of benmelstobart (a novel programmed death-ligand 1 (PD-L1) inhibitor) anlotinib multi-target anti-angiogenic small molecule) chemotherapy in treatment-naive ES-SCLC. The assessed two primary endpoints:...
Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is indispensable. This study aimed to investigate the clinical characteristics outcomes such patients.A retrospective was conducted on 29 hospitals regions during period 2013 2014. Demographic features, pre-admission conditions, details, were summarized. Risk factors severity analyzed.There 3,240...
The aim of the present study was to investigate influence hypoxia and PI3K inhibition on angiogenic factors in A549 lung cancer cells. cells were treated with inhibitor LY294002 under normoxic hypoxic conditions. Untreated used as control group those by inhibitor, suppression group. further divided based or conditions named: Normoxic group, Expression levels hypoxia-inducible factor (HIF)-1α AKT1 mRNA all groups determined reverse transcriptase-quantitative polymerase chain reaction...
Objective: To assess the overall asthma control level in urban China. Methods: A multi-center, cross-sectional, questionnaire-based survey was carried out 30 provinces China (except Tibet). Asthmatic outpatients who met inclusion criteria were recruited consecutively from sub-centers October 2015 to May 2016. Data of demographic characteristics, control, management, exacerbations and self-management, disease perception collected by face-to-face interviews. Results: Totally 3 875 asthmatic...
As stated in the Global Initiative for Asthma, there are still some asthmatic patients who have not achieved asthma control. Mobile is a useful tool management. We aimed to compare advantages of mobile management with traditional improving adherence and control asthma.In this prospective, multicentre, randomized, controlled parallel-group study, we enrolled poor uncontrolled at 32 hospitals 28 provinces China. Patients were randomly assigned or groups 12 months. The primary endpoint was...
Abstract COPD is the fourth leading cause of mortality, and predicted to be third death worldwide by 2020. But few studies on Tibetan China. This study identifies distinctive miRNA signatures in patients from healthy subjects that could serve as diagnostic biomarkers or describe differential molecular mechanisms with potential therapeutic implications. In this study, a total 210 differentially expressed miRNAs were screened. Analysis functions target genes via GO enrichment analysis revealed...
Objective: To evaluate the changes of asthma control, disease management and perception in recent years China. Methods: We conducted 2 multi-center, cross-sectional surveys. Outpatient asthmatic patients from 10 cities mainland China (2007-2008) 30 central provinces (except Tibet)(2015-2016) were recruited respectively. Data surveys compared for which took part both Chi-square test was used comparison between groups. Results: The control level improved 28.7%(839/2 928) 2007-2008 to...
While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer control, the impact on hospitalisation for exacerbation (H-AX) remains less recognised. We aim to analyse H-AX.Based a national survey control disease perception (CARN 2015 study), we analysed annual incidence frequency H-AX in China. Information demographic characteristics, were presented this study.Among 3875 ambulatory patients, 75.9% (2941/3875) had comorbidities, 26.4%...
Aims: Despite efforts to promote physical activity, the prevalence of inactivity continues rise. Exercise access influences population activity levels, but county-level variation in and its link cardiovascular disease (CVD) mortality is unclear. We explored associations between exercise opportunities, levels inactivity, CVD across U.S. counties Methods: The County Health Rankings Roadmaps data CDC WONDER were integrated. compared age-adjusted quartiles opportunities inactivity....
Abstract Background Baicalin (C 21 H 18 O 11 ) is a flavonoid component extracted from scutellaria baicalensis with biological activity in various types of diseases, including acute lung injury (ALI). The relevant mechanism behind baicalin ALI needs further investigation. Methods model vitro was established by lipopolysaccharide (LPS) WI-38 cells (lung fibroblast). Cell growth determined via MTT assay and EdU assay. Apoptosis assessed using flow cytometry, caspase 3 TUNEL Oxidative...
Objective: To study the seasonal characteristics of patients hospitalized for asthma exacerbation in China. Methods: This was a retrospective which involved 29 hospitals throughout mainland China during 2013-2014. The number each hospital calculated, as well ratio asthmatic to all patients. analysis by month conducted. and northern southern cities were calculated respectively. Results: During period, there 6 480 exacerbation, accounting 3.14% (6 480/206 135) respiratory department hospitals....
<b>Objective:</b> To evaluate the overall asthma control level in urban China and provide evidence for prevention management of asthma. <b>Methods:</b> A multi-center, cross-sectional, questionnaire-based survey was carried out 30 provinces (except Tibet). <b>Results:</b> 3,875 asthmatic outpatients were recruited. Asthma assessed according to GINA 2015. The prevalence area 28.5%. Among 10 cities, which also took part 2008, improved from 28.7% 2008 39.2% 2016. rate hospitalization due...
Objective: To investigate warning symptoms of asthma attack and evaluate self-management status patients in urban China. Methods: A multi-center, cross-sectional, questionnaire-based survey was carried out from 30 general hospitals dispersed provinces mainland China (except for Tibet) during Oct 2015 to May 2016. Information frequency attack, the time impact were collected outpatient department. Results: Altogether 3 875 asthmatic outpatients recruited. 78.1% (3 026/3 875) reported...
Objective: To investigate the current perception of disease among asthmatic patients in Chinese urban areas, and to address its association with asthma control. Methods: This was a nationwide, multi-center, cross-sectional study covering 30 third-level, grade A hospitals provinces, municipalities autonomous regions (not including Tibet) across mainland. The survey carried out from October 2015 May 2016. Asthmatic outpatients were selected receive face-to-face questionnaire on control Asthma...
Objective: To evaluate the general level of asthma management in urban areas China and further promote national plan. Methods: A multi-center, cross-sectional survey was carried out 30 provinces (except for Tibet) during Oct 2015 to May 2016. It's a questionnaire-based face-to-face which included using peak flow meter (PFM) pulmonary function test, medication choice maintenance therapy education. Results: total 3 875 asthmatic outpatients were recruited including 2 347(60.6%) females 1...
Objective: To understand the seasonal distribution of patient hospitalization due to asthma exacerbation in 7 geographic areas China. Methods: This was a retrospective study which involved patients hospitalized for 29 hospitals throughout mainland China (northeast, north, central, east, south, northwest and southwest). The numbers asthmatic total inpatients respiratory department each hospital were recorded. monthly ratio every area calculated compared. Results: During period, 6 480 admitted...
<b>Background:</b> The epidemiologic evidence related to asthma control in China is not been fully characterized. We sought assess according the GINA guidelines and investigate risk factors associated with uncontrolled nationally representative centers. <b>Methods:</b> A face survey was administered 3,875 asthmatic patients aged over 14 years, resided study city for at least 2 years diagnosed of 3 months. Asthma assessed by using proposal (controlled, partly controlled, asthma), it potential...
Objective: In order to evaluate disease perception of asthma patients in urban China and provide evidence for further specific patient education. Methods: A multi-center, cross-sectional, questionnaire-based survey was carried out 30 general hospitals dispersed provinces mainland (except Tibet) during Oct 2015 May 2016. Information [Question 1: the nature asthma; Question 2: medication choice first-line chronic 3: occasion using short-acting aerosols receptor agonists; 4: treatment goal; 5:...
Micro ribonucleic acid (miRNA) expression profile in non‑small cell lung cancer (NSCLC) tissues middle‑altitude area was analyzed using the Affymetrix chip technique, to predict target genes of abnormally‑expressed miRNAs, and analyze gene‑related signaling pathways biological functions regulated by them. The difference miRNA NSCLC technique. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) performed for verification some differentially‑expressed miRNAs. predicted at...
Objective Serum of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor metalloproteinases-1 (TIMP-1) levels moderate severe acute exacerbations chronic obstructive pulmonary disease (AECOPD) patients before after treatment were tested using ELISA to observe the effect montelukast modiumr on serum MMP-9 TIMP-1 levels.Methods Sixty-three cases mild AECOPD selected that randomly divided into 30 as group 33 control group.The given conventional therapy plus sodium (10 mg oral once-daily for...
Objective Serum levels of MMP-9 and TIMP-1 in bronchial asthma (asthma) patients before after montelukast soudium treatment were tested through ELISA to observe the effect on serum TIMP-1.Methods Sixty-one cases mild persistent selected randomly divided into 29 as group 32 control group.The given conventional therapy plus 10 mg oral once-daily for 7-14 days.While days.Serum respectively using compared with their changes.Results ①The level [(22.75± 6.51) μg/L] lower than those groups...
Objective: To evaluate the influencing factors of poor treatment adherence in patients with uncontrolled asthma China. Methods: From April 2017 to 2018, all and compliance 32 third-class hospitals 28 provinces cities China mainland included "National Mobile Asthma Assessment Management Project" were selected as subjects. A total 923 enrolled study including 388 males 535 females. By analyzing baseline data at initial visit when enrolled, adult was analyzed by inter-group comparison χ2 test....
Abstract Background ICS-based maintenance treatment was the basic of asthma. Nevertheless, data real-world study on asthma outcome limited. Methods Based a national survey control and disease perception (CARN-2015-01 study), we analysed impact outcome: control, annual incidence exacerbation hospitalization emergency department visit in China. Results Altogether 3875 asthmatic outpatients were recruited. 66.7% (2583/3875) patients chose as daily treatment. After adjusting for confounding...