A5037750778- Pediatric health and respiratory diseases
- Carbohydrate Chemistry and Synthesis
- Immunodeficiency and Autoimmune Disorders
- Public Health and Nutrition
- Biochemical and Molecular Research
- Health and Medical Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Enzyme Production and Characterization
- Human Health and Disease
- HIV/AIDS drug development and treatment
- Asthma and respiratory diseases
- Immune responses and vaccinations
- Glycosylation and Glycoproteins Research
China Pharmaceutical University
2024
2′-Deoxynucleosides and analogues play a vital role in drug development, but their preparation remains significant challenge. Previous studies have focused on β-2′-deoxynucleosides with the natural β-configuration. In fact, isomeric α-2′-deoxynucleosides also exhibit diverse bioactivities even better metabolic stability. Herein, we report that both α- can be prepared high yields stereoselectivity using remote directing diphenylphosphinoyl (DPP) group. It is particularly efficient to prepare...
Starfish provide important saponins with diverse bioactivities as the secondary metabolites, among which 2-O-glycosylated glycosides are commonly found. Preparation of those 1,2-trans usually relies on 2-O-acyl participation requiring selective installation and cleavage groups. A convergent synthesis using oligosaccharide donors would be more straightforward but also pose greater challenges. Herein, we report a distinctive tetrasaccharide isolated from starfish Asterias rollestoni Bell. Dual...
Objective: To assess the overall asthma control level in urban China. Methods: A multi-center, cross-sectional, questionnaire-based survey was carried out 30 provinces China (except Tibet). Asthmatic outpatients who met inclusion criteria were recruited consecutively from sub-centers October 2015 to May 2016. Data of demographic characteristics, control, management, exacerbations and self-management, disease perception collected by face-to-face interviews. Results: Totally 3 875 asthmatic...
Objective: To study the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China. Methods: Patients at 29 hospitals China were retrospectively recruited during 2013-2014. Results: Clinical data 3 240 asthmatic collected analyzed including 1 369(42.3%) males 871(57.7%) females. The counted 2.95% (6 375/215 955) all same period. leading six factors, sequence, acute upper respiratory tract infection [42.3%(1 370/3 240)], changes weather...
Objective: To study the seasonal characteristics of patients hospitalized for asthma exacerbation in China. Methods: This was a retrospective which involved 29 hospitals throughout mainland China during 2013-2014. The number each hospital calculated, as well ratio asthmatic to all patients. analysis by month conducted. and northern southern cities were calculated respectively. Results: During period, there 6 480 exacerbation, accounting 3.14% (6 480/206 135) respiratory department hospitals....