A5042714060- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Adaptive Control of Nonlinear Systems
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Guidance and Control Systems
- Fault Detection and Control Systems
- Control and Dynamics of Mobile Robots
- Advanced Control Systems Optimization
- Stability and Control of Uncertain Systems
- Robotic Path Planning Algorithms
- HIV/AIDS drug development and treatment
- Inertial Sensor and Navigation
Tianjin University of Technology
2024-2025
China Pharmaceutical University
2021-2024
2′-Deoxynucleosides and analogues play a vital role in drug development, but their preparation remains significant challenge. Previous studies have focused on β-2′-deoxynucleosides with the natural β-configuration. In fact, isomeric α-2′-deoxynucleosides also exhibit diverse bioactivities even better metabolic stability. Herein, we report that both α- can be prepared high yields stereoselectivity using remote directing diphenylphosphinoyl (DPP) group. It is particularly efficient to prepare...
Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining biological functions and activities carbohydrate molecules. However, their stereochemistry control in glycosylation represents one most challenging tasks chemistry. In this report, easily accessible 2‐diphenylphosphinoyl‐acetyl (DPPA) group was developed as a highly stereodirecting catalytic via hydrogen‐bond mediated delivery alcoholic acceptors. TMSOTf‐catalyzed with DPPA‐installed...
The anomeric configuration can greatly affect the biological functions and activities of carbohydrates. Herein, we report that N-phenyltrifluoroacetimidoyl (PTFAI), a well-known leaving group for catalytic glycosylation, act as stereodirecting challenging 1,2-cis α-glycosylation. Utilizing rapidly accessible 1,6-di-OPTFAI glycosyl donors, TMSOTf-catalyzed glycosylation occurred with excellent α-selectivity broad substrate scope, remaining 6-OPTFAI be cleaved chemoselectively. remote...
Anomeric stereocontrol is usually one of the major issues in synthesis complex carbohydrates, particularly those involving β-configured 2,6-dideoxyglycoside and d/l-rhamnoside moieties. Herein, we report that 2-(diphenylphosphinoyl)acetyl highly effective as a remote stereodirecting group direct these challenging β-glycosides under mild conditions. A deoxy-trisaccharide mimic sugar chain landomycin E was prepared stereospecifically high yield. The synthetic potential also highlighted...
ABSTRACT The supermaneuver flight control problem of fighter aircraft with thrust vector is addressed by proposing a cascade strategy that incorporates disturbance compensation and allocation technology. Firstly, an active rejection (ADRC) introduced, which employs predefined time extended state observer (PTESO) to ensure the convergence estimation errors within time. Secondly, technology implemented address challenges in over‐actuated system aircraft. In addition, efficient utilized...
This paper proposes a sliding mode control strategy with predefined time convergence for addressing the attitude problem of aircraft. Firstly, extended state observer is developed to realize estimation modelling error, uncertainty and external disturbance aircraft within time. Secondly, non-singular terminal reaching law are proposed Especially, address potential singularities arising from negative power terms, switching employed. Finally, numerical simulations Monte Carlo test used validate...
Abstract The anomeric configuration can greatly affect the biological functions and activities of carbohydrates. Herein, we report that N ‐phenyltrifluoroacetimidoyl (PTFAI), a well‐known leaving group for catalytic glycosylation, act as stereodirecting challenging 1,2‐ cis α‐glycosylation. Utilizing rapidly accessible 1,6‐di‐OPTFAI glycosyl donors, TMSOTf‐catalyzed glycosylation occurred with excellent α‐selectivity broad substrate scope, remaining 6‐OPTFAI be cleaved chemoselectively....
Abstract Anomeric stereocontrol is usually one of the major issues in synthesis complex carbohydrates, particularly those involving β‐configured 2,6‐dideoxyglycoside and d / l ‐rhamnoside moieties. Herein, we report that 2‐(diphenylphosphinoyl)acetyl highly effective as a remote stereodirecting group direct these challenging β‐glycosides under mild conditions. A deoxy‐trisaccharide mimic sugar chain landomycin E was prepared stereospecifically high yield. The synthetic potential also...
The configuration of the anomeric glycosidic linkages is crucial for maintaining biological functions and activities carbohydrate molecules. However, their stereochemistry control in glycosylation represents one most challenging tasks chemistry. In this report, easily accessible 2-diphenylphosphinoyl-acetyl (DPPA) group was developed as a highly stereodirecting catalytic via hydrogen-bond mediated delivery alcoholic acceptors. TMSOTf-catalyzed with 6-O-DPPA glycosyl imidate donors displayed...
The configuration of the anomeric glycosidic linkages is crucial for maintaining biological functions and activities carbohydrate molecules. However, their stereochemistry control in glycosylation represents one most challenging tasks chemistry. In this report, easily accessible 2-diphenylphosphinoyl-acetyl (DPPA) group was developed as a highly stereodirecting catalytic via hydrogen-bond mediated delivery alcoholic acceptors. TMSOTf-catalyzed with 6-O-DPPA glycosyl imidate donors displayed...