A5057789787- Carbohydrate Chemistry and Synthesis
- Natural Antidiabetic Agents Studies
- Glycosylation and Glycoproteins Research
- Plant and animal studies
- Enzyme Production and Characterization
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Synthesis and Biological Activity
- Chemical Synthesis and Analysis
- Plant Reproductive Biology
- Plant biochemistry and biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Biochemical and Molecular Research
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Bioactive Natural Diterpenoids Research
- Plant Diversity and Evolution
- Pneumocystis jirovecii pneumonia detection and treatment
- Ecology and Conservation Studies
- Plant Stress Responses and Tolerance
- Natural product bioactivities and synthesis
- Bioactive natural compounds
- Plant tissue culture and regeneration
- Photosynthetic Processes and Mechanisms
China Pharmaceutical University
2016-2025
Yunnan Academy of Agricultural Sciences
2011-2024
Nanjing University
2024
Guangdong University of Technology
2024
Ji Hua Laboratory
2024
Army Medical University
2020-2023
Xiangya Hospital Central South University
2023
Central South University
2023
Union Hospital
2022
Fujian Medical University
2022
Be economic with your atoms! An efficient Rh-catalyzed oxidative olefination of indoles and pyrroles broad substrate scope tolerance is reported (see scheme). The catalytic reaction proceeds excellent regio- stereoselectivity. directing group N,N-dimethylcarbamoyl was crucial for the could be removed easily. Mizoroki–Heck one most important metal-catalyzed cross-coupling reactions formation a CC bond from CX bond.1 However, direct CH transformations allow use less expensive more readily...
The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, application oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series A-ring modified analogues, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized, evaluated anticancer efficacy. Some significantly more potent than against both drug-sensitive drug-resistant cells. most compound, 13p, 200-fold...
An efficient ruthenium-catalyzed oxidative coupling of indoles and pyrroles with various alkenes at the C2-position assisted by employing N,N-dimethylcarbamoyl moiety as a directing group is reported. The catalytic reaction proceeds in an excellent regio- stereoselective manner.
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in southwest China covers several different habitats and environments. However, not much research had been conducted on spp. at the molecular level, which hinders understanding of its evolution, speciation, synthesis secondary metabolites, well wide adaptability to Here, we report genome assembly gene annotation R. var. (the second sequenced Ericaceae), will facilitate study family. The have further...
Rh(III)-catalyzed ortho C–H olefination of aryl sulfonamide directed by the SO2NHAc group is reported. This oxidative coupling process achieved highly efficiently and selectively with a broad substrate scope. The reactions N-tosylacetamide acrylate esters afford ortho-alkenylated benzofused five-membered cyclic sulfonamides, whereas styrenes provide direct diolefination products.
Proteolysis targeting chimeras (PROTACs) is a promising strategy for cancer therapy. However, the always-on bioactivity of PROTACs may lead to non-target toxicity, which restricts their antitumor performance. Here, we developed an X-ray radiation responsive PROTAC nanomicelle (RCNprotac) by covalently conjugating reported small molecule (MZ1) hydrophilic PEG
2′-Deoxynucleosides and analogues play a vital role in drug development, but their preparation remains significant challenge. Previous studies have focused on β-2′-deoxynucleosides with the natural β-configuration. In fact, isomeric α-2′-deoxynucleosides also exhibit diverse bioactivities even better metabolic stability. Herein, we report that both α- can be prepared high yields stereoselectivity using remote directing diphenylphosphinoyl (DPP) group. It is particularly efficient to prepare...
Primary amines serve as key synthetic precursors to most other
Oridonin (1) is a complex ent-kaurane diterpenoid exhibiting remarkable antitumor activity. However, the detailed mechanism or cellular target that underlies this activity has not yet been identified. Herein, we report an efficient approach for exploring anticancer of oridonin through development potent fluorescent analogues. A series novel probes linked with coumarin moieties were designed, synthesized, and characterized. Fluorescence microscopy confocal imaging studies suggested probe 17d...
The anomeric configuration can greatly affect the biological functions and activities of carbohydrates. Herein, we report that N-phenyltrifluoroacetimidoyl (PTFAI), a well-known leaving group for catalytic glycosylation, act as stereodirecting challenging 1,2-cis α-glycosylation. Utilizing rapidly accessible 1,6-di-OPTFAI glycosyl donors, TMSOTf-catalyzed glycosylation occurred with excellent α-selectivity broad substrate scope, remaining 6-OPTFAI be cleaved chemoselectively. remote...
Anomeric stereocontrol is usually one of the major issues in synthesis complex carbohydrates, particularly those involving β-configured 2,6-dideoxyglycoside and d/l-rhamnoside moieties. Herein, we report that 2-(diphenylphosphinoyl)acetyl highly effective as a remote stereodirecting group direct these challenging β-glycosides under mild conditions. A deoxy-trisaccharide mimic sugar chain landomycin E was prepared stereospecifically high yield. The synthetic potential also highlighted...
We report the first attempt of double-spot structural modification on a side-chain moiety sulfonium-type α-glucosidase inhibitors isolated from genus Salacia. A series sulfonium salts with benzylidene acetal linkage at C3′ and C5′ positions were designed synthesized. In vitro enzyme inhibition evaluation showed that compounds strong electron-withdrawing group attached ortho position phenyl ring present stronger inhibitory activities. Notably, most potent inhibitor 21b (1.0 mpk) can exhibit...
Rhododendron delavayi Franch is an evergreen shrub or small tree with large scarlet flowers that makes it highly attractive as ornamental species. The species native to southwest China and southeast Asia, especially the Himalayan region, showing good adaptability tolerance drought. To understand water stress coping mechanisms of R. delavayi, we analysed plant's photosynthetic performance during recovery. In particular, looked at regulation stomatal (gs) mesophyll conductance (gm), maximum...
Abstract Reproductive isolation (RI) plays an important role for speciation, but assessing reproductive barriers at all life-cycle stages remains challenging. In plants, most studies addressing the topic have been focusing on herbs with short generation times. The present study attempted to quantify several between a hybridizing species pair of long-lived woody rhododendrons. Consistent findings previous studies, pre-zygotic contributed more total RI than post-zygotic barriers. Especially in...
Comprehensive Summary The configuration of the anomeric glycosidic linkages is crucial for maintaining biological functions and activities carbohydrate molecules. However, their stereochemistry control in glycosylation represents one most challenging tasks chemistry. In this report, easily accessible 2‐diphenylphosphinoyl‐acetyl (DPPA) group was developed as a highly stereodirecting catalytic via hydrogen‐bond mediated delivery alcoholic acceptors. TMSOTf‐catalyzed with DPPA‐installed...
Presented herein is the chemical construction of unprecedented 3,4‐trans‐3,6‐anhydro hexofuranose frameworks. The disfavored 3,6‐anhydro hexofuranosides were effectively established by Pd‐catalyzed debenzylative intramolecular acetalation for first time. critical roles benzyl protection and Pd as catalyst demonstrated. Various sugars including sauropunol E was obtained in satisfactory yields. Pharmaceutical investigation its analogues revealed their potential application anti‐inflammatory agents.
Heteromorphy in flowers has a profound effect on breeding patterns within species, but little is known about how it affects reproductive barriers between species. The heterostylous genus Primula very diverse the Himalaya region, hybrids there have been researched. This study examines detail natural hybrid zone P. beesiana and bulleyana. Chloroplast sequencing, AFLP (amplified fragment length polymorphism) markers morphological comparisons were employed to characterize putative field, using...
Structurally unique 6,7-seco-ent-kaurenes, which are widely distributed in the genus Isodon, have attracted considerable attention because of their antitumor activities. Previously, a convenient conversion commercially available oridonin (1) to 6,7-seco-ent-kaurenes was developed. Herein, several novel spiro-lactone-type ent-kaurene derivatives bearing various substituents at C-1 and C-14 positions were further designed synthesized from natural product oridonin. Moreover, number...