A5048821605- Natural product bioactivities and synthesis
- Magnetic confinement fusion research
- Phytochemistry and Biological Activities
- Ionosphere and magnetosphere dynamics
- Carbohydrate Chemistry and Synthesis
- Laser-Plasma Interactions and Diagnostics
- Particle accelerators and beam dynamics
- Phytochemical Studies and Bioactivities
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Plasma Diagnostics and Applications
- Fusion materials and technologies
- Ginger and Zingiberaceae research
- Plant biochemistry and biosynthesis
- Bioactive natural compounds
- Solar and Space Plasma Dynamics
- Ginseng Biological Effects and Applications
- Sesquiterpenes and Asteraceae Studies
- Traditional Chinese Medicine Analysis
- Magnetic properties of thin films
- Synthesis and Biological Activity
- Superconducting Materials and Applications
- Chromatography in Natural Products
- Phytochemistry and Bioactive Compounds
University of Tsukuba
2016-2025
Industrial Research Institute of Shizuoka Prefecture
2010-2025
Plasma (Russia)
2015-2025
Kyoto Pharmaceutical University
2013-2023
Kindai University
2013-2023
Showa University
2021-2022
The Japanese Society of Gastroenterological Surgery
2021
National Institute for Fusion Science
2016-2021
Jikei University School of Medicine
2021
Iwate Medical University
2021
Adjuvant and haemolytic activities of 47 saponins purified from medicinal food plants were examined. The compounds showed various levels both adjuvant activities. Soyasaponins lablabosides strong activity but little activity. Jujubosides Escins weaker than the adjuvant-control, Comparison functional groups each saponin revealed that acyl residue in saponin, aldehyde group at carbon 4 aglycone, branched sugar chains attached to not essential for Furthermore, with an or oxide-ring moiety...
We investigate extremely low programming current and fast switching time of a perpendicular tunnel-magnetoresistance (P-TMR) for spin-transfer torque using P-TMR cell 50 nm-diameter. A L1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -crystalline ordered alloy is used as free layer that has excellent thermal stability damping constant about 0.03. The 49 uA the 4 nsec are also demonstrated.
Perpendicular L1 <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> -FePt/MgO/Fe/L1 -FePt magnetic tunnel junction (MTJ) films with the (001) texture were successfully developed to obtain a large magnetoresistance (TMR) above 100 % at room temperature. The TMR ratio in MTJ was strongly dependent on Fe interfacial layer thickness. lattice mismatch between MgO(001) barrier and -FePt(001) is too for MgO grow epitaxially layer. insertion of...
During the studies on chemical characterization of crude drug precession, constituents Ginseng Radix Rubra were investigated by comparing with those Radix. Panaxynol (4), ginsenosides Ro, Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2 (11), Rg3 (10a), and Rh1 (9) identified as common both Ginseng, whereas panaxytriol (1), ginsenoside Rh2 (8), 20 (R)-ginsenoside (9a), (S)-ginsenoside (10), (11a) elucidated characteristic Rubra. It was also found that contained larger quantities (9), (11) than The less...
The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids isolated as the active constituents by bioassay-guided separation, among them, quercitrin (IC(50)=0.15 microM), guaijaverin (0.18 desmanthin-1 (0.082 microM) exhibited potent activity. Desmanthin-1 showed activity, which was equivalent that a commercial synthetic reductase inhibitor, epalrestat (0.072 microM). order...
Abstract Background The rhizomes of Panax japonicus are used as a folk medicine for treatment life-style related diseases such arteriosclerosis, hyperlipidemia, hypertension and non-insulin-dependent diabetes mellitus substitute ginseng roots in China Japan. Obesity is closely associated with life-style-related diseases. This study was performed to clarify whether chikusetsusaponins prevent obesity induced mice by high-fat diet 9 weeks. Methods We two vivo experiments. In one, female ICR...
The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit increase serum glucose levels in sucrose-loaded rats at a dose 250 mg/kg, p.o. From extract, six new spirostane-type steroid saponins, borassosides A—F (1—6), were isolated together with 23 known constituents. structures (1—6) elucidated on basis chemical and physicochemical evidences. In addition, principal saponin, dioscin (13), inhibited 50
For the first time, 4Gbit density STT-MRAM using perpendicular MTJ in compact cell was successfully demonstrated through tight distributions for resistance and magnetic properties. This paper includes results regarding parasitic control process, stack engineering. Both of successful 4Gb read write operations were performed with high TMR, low Ic. result will brighten prospect high-density STT-MRAM.
The 80% aqueous methanolic extract from the bulbs of Crinum yemense showed a potent inhibitory effect on nitric oxide production in lipopolysaccharide-activated macrophages. Three new crinine-type alkaloids, yemenines A (1), B (2), and C (3), were isolated herbal together with six known alkaloids. absolute configurations 1−3 determined basis chemical physicochemical evidence. effects alkaloids macrophages examined, several e.g. 1, (+)-bulbispermine (6), (+)-crinamine (7),...
The saponin fraction from the flower buds of Panax notoginseng exhibited protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. From with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-O (1), -P (2), -Q (3), -S (4), -T (5), were isolated together nine known protopanaxadiol oligoglycosides. structures saponins elucidated basis chemical physicochemical evidence. principal roots found to show potent effects.
Eight cucurbitane-type triterpene glycosides called goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h three oleanane-type saponins termed goyasaponins I, II, III were isolated from the fresh fruit of Japanese Momordica charantia L. (Cucurbitaceae) together with five known momordicosides A, C, F1, K. The structures goyaglycosides elucidated on basis chemical physicochemical evidence.
Mangiferin, three catechins, and two catechin dimers were isolated from the roots of Salacia reticulata (SRE), examined their inhibitory activities against several carbohydrate metabolize enzymes (sucrase, maltase, isomaltase, α-amylase, aldose reductase). Among them, mangiferin was found to inhibit sucrase, reductase rat with IC50 values 87, 216 1.4 μg/ml, respectively. The are competitive for sucrase isomaltase inhibitor constant (Ki) 55 μg/ml 70 In order determine contents in water...
The methanolic extract and its 1-butanol-soluble fraction from the flowers of Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity gastric emptying, gastroprotective effect. From fraction, four new triterpene oligoglycosides, calendasaponins A, B, C, D, isolated, together with eight known saponins, seven flavonol glycosides, sesquiterpene glucoside. Their structures elucidated on basis chemical physicochemical evidence. principal saponin constituents,...
We investigated the antihyperglycemic action of a crude saponin fraction and five triterpene glycosides (gymnemic acids I-IV gymnemasaponin V) derived from methanol extract leaves Gymnema sylvestre R. BR. (Asclepiadaceae) in streptozotocin (STZ)-diabetic mice. The (60mg/kg) reduced blood glucose levels 2 4h after intraperitoneal administration. Gymnemic acid IV, not other 4 at doses 3.4-13.4mg/kg by 13.5-60.0% 6h administration comparable to potency glibenclamide, did change normal IV 13.4...
Two new flavanone glycosides, (2S)- and (2R)-eriodictyol 7-O-beta-D-glucopyranosiduronic acids, a phenylbutanoid glycoside, (2S, 3S)-1-phenyl-2,3-butanediol 3-O-beta-D-glucopyranoside, were isolated from the flowers of Chrysanthemum indicum L. cultivated in China together with eight flavonoids. The absolute stereostructures compounds determined on basis chemical physicochemical evidence. Both glycosides found to show inhibitory activity for rat lens aldose reductase.