A5100407635- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Microbial Natural Products and Biosynthesis
- Morinda citrifolia extract uses
- Bioactive Compounds and Antitumor Agents
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Microbial Metabolism and Applications
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- Immunotherapy and Immune Responses
- Radical Photochemical Reactions
- Organoboron and organosilicon chemistry
- Immune Response and Inflammation
- Asymmetric Synthesis and Catalysis
- Fungal Biology and Applications
- Sulfur-Based Synthesis Techniques
- RNA Interference and Gene Delivery
- Catalytic Cross-Coupling Reactions
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Peptides and Activities
- Asymmetric Hydrogenation and Catalysis
- Advanced Synthetic Organic Chemistry
- T-cell and Retrovirus Studies
University of South China
2018-2025
China Pharmaceutical University
2016-2025
Guangdong University of Technology
2022-2024
University of Münster
2023-2024
Ocean University of China
2024
Donghua University
2021-2024
Qingdao University
2024
Jiangnan University
2023
Inner Mongolia Medical University
2023
Second Military Medical University
2023
The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/) is an original initially online in 2003. APD2 (2009 version) has been regularly updated and further expanded into the APD3. This currently focuses on natural peptides (AMPs) with defined sequence activity. It includes a total of 2619 AMPs 261 bacteriocins from bacteria, 4 archaea, 7 protists, 13 fungi, 321 plants 1972 animal host defense peptides. APD3 contains 2169 antibacterial, 172 antiviral, 105 anti-HIV, 959 antifungal,...
An antimicrobial peptide database (APD) has been established based on an extensive literature search. It contains detailed information for 525 peptides (498 antibacterial, 155 antifungal, 28 antiviral and 18 antitumor). APD provides interactive interfaces query, prediction design. also statistical data a select group of or all the in database. Peptide can be searched using keywords such as name, ID, length, net charge, hydrophobic percentage, key residue, unique sequence motif, structure...
cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, it imperative to identify effective lead compounds that specifically downregulate the pathway. We report here astin C, a cyclopeptide isolated from medicinal plant Aster tataricus, inhibits inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with C are more susceptible HSV-1 infection. Consistently, markedly attenuates in Trex1-/- BMDM...
Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored anti-inflammatory activity artemisinin and underlying mechanism action. We demonstrated that effects in TPA-induced skin inflammation mice. Then significantly inhibited expression NF-κB reporter gene induced by TNF-α a dose-dependent manner. Artemisinin also phosphorylation degradation IκBα, p65 nuclear translocation. an impact...
Multiple myeloma (MM) remains to be incurable despite recent therapeutic advances. CD47, an immune checkpoint known as the “don’t eat me” signal, is highly expressed on surface of various cancers, allowing cancer cells send inhibitory signals macrophages and impede phagocytosis response. In this study, we hypothesized that blocking signaling using anti-CD47 monoclonal antibody will induce killing MM cells. We report CD47 expression was directly correlated with stage disease, from normal MGUS...
A visible light-initiated manganese-catalyzed radical hydrosulfonylation of a wide range structurally diverse alkenes using commercially available and relatively cheap sulfonyl chlorides as sources is described.
Abstract Difluoromethyl pyridines have gained significant attention in medicinal and agricultural chemistry. The direct C−H-difluoromethylation of represents a highly efficient economic way to access these azines. However, the meta-difluoromethylation has remained elusive methods for site-switchable regioselective meta- para-difluoromethylation are unknown. Here, we demonstrate meta-C−H-difluoromethylation through radical process by using oxazino pyridine intermediates, which easily accessed...
2′-Deoxynucleosides and analogues play a vital role in drug development, but their preparation remains significant challenge. Previous studies have focused on β-2′-deoxynucleosides with the natural β-configuration. In fact, isomeric α-2′-deoxynucleosides also exhibit diverse bioactivities even better metabolic stability. Herein, we report that both α- can be prepared high yields stereoselectivity using remote directing diphenylphosphinoyl (DPP) group. It is particularly efficient to prepare...
Background and Purpose Myeloid differentiation 2 ( MD ‐2) recognizes LPS , which is required for TLR 4 activation, represents an attractive therapeutic target severe inflammatory disorders. We previously found that a chalcone derivative, L6H 21, could inhibit ‐induced overexpression of TNF ‐α IL ‐6 in macrophages. Here, we performed series biochemical experiments to investigate whether 21 specifically targets ‐2 inhibits the interaction signalling transduction ‐TLR4/ ‐2. Experimental...
d Genetic loss of TRAF3 is associated with
Endotoxin-induced acute inflammatory diseases such as sepsis, mediated by excessive production of various proinflammatory cytokines, remain the leading cause mortality in critically ill patients. Lipopolysaccharide (LPS), characteristic endotoxin found outer membrane Gram-negative bacteria, can induce innate immunity system and through myeloid differentiation protein 2 (MD2) Toll-like receptor 4 (TLR4) complex, increase mediators. Our previous studies have that a curcumin analog, L48H37...
Developing green and efficient technologies for surface modification of magnetic nanoparticles (MNPs) is crucial importance their biomedical environmental applications. This study reports, the first time, a novel strategy by integrating metal-free photoinduced electron transfer-atom transfer radical polymerization (PET-ATRP) with bioinspired polydopamine (PDA) chemistry controlled architecture functional polymer brushes from MNPs. Conformal PDA encapsulation layers were initially generated...
Activation of the stimulator interferon genes (STING) pathway to achieve antitumor response is an attractive approach for cancer immunotherapy. In this study, we report identification BSP16 (LF250) as a potent, orally available STING agonist. strongly activates signaling in human and mouse cells binds homodimer. A 2.4 Å cocrystal structure revealed that could induce "closed" conformation STING. vivo studies well tolerated, has excellent pharmacokinetic profile oral drug, induces tumor...
Colorectal cancer (CRC) is an exceptionally deadly disease, whereas effective therapeutic drugs for CRC have declined over the past few decades. Natural products become a reliable source of anticancer drugs. Previously we isolated alkaloid named (−)-N-hydroxyapiosporamide (NHAP), which exerts potent antitumor effects, but its effect and mechanism in remain unclear. This study aimed to reveal target NHAP identify as promising lead compound CRC. Various biochemical methods animal models were...
Thirteen new sativene sesquiterpenoids (1 and 3–14), one natural product (2), 16 known compounds (15–30) were isolated from the endophytic fungus Bipolaris victoriae S27. Their structures elucidated by extensive spectroscopic analysis, NMR ECD calculations, X-ray crystal diffractions. Compound 1 represented first example of with a 6/5/3/5-caged tetracyclic ring system. All obtained evaluated for their plant-growth regulatory activity. The results showed that 1, 3, 4, 6, 8, 11, 12, 17, 19,...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of cancer. Cuproptosis, novel identified cell death form, triggered by the direct binding copper to lipoylated components tricarboxylic acid cycle. Identifying new effective drug targets and ionophores inducing cuproptosis for TNBC therapy an urgent clinical need. In this study, total 24 resorcylic lactones (RALs, 1–24), including 9 previously unreported ones, were isolated from endophyte Ilyonectria sp. Various assays...