A5028876213- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Vitamin D Research Studies
- Multiple Sclerosis Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Occupational and environmental lung diseases
- Lipid metabolism and biosynthesis
Bayer (Germany)
2014-2024
Max Delbrück Center
2010-2021
Humboldt-Universität zu Berlin
2021
Charité - Universitätsmedizin Berlin
2010-2021
Freie Universität Berlin
2021
Ludwig-Maximilians-Universität München
2017
University Hospital Münster
2017
University of Bologna
2017
Hôpital Maisonneuve-Rosemont
2017
MSB Medical School Berlin
2011
IMPORTANCE It remains unclear whether vitamin D insufficiency, which is common in individuals with multiple sclerosis (MS), has an adverse effect on MS outcomes.OBJECTIVES To determine serum concentrations of 25-hydroxyvitamin (25[OH]D), a marker status, predict disease activity and prognosis patients first event suggestive (clinically isolated syndrome). DESIGN, SETTING, AND PARTICIPANTSThe Betaferon/Betaseron Newly Emerging For Initial Treatment study was randomized trial originally...
Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K-α -δ isoforms, has demonstrated efficacy manageable safety profile in patients indolent lymphoma. Patients Methods In this phase II study, 142 relapsed or refractory lymphoma after two more lines therapy were enrolled to receive copanlisib 60 mg intravenously on days 1, 8, 15 28-day cycle....
Background & AimsIn a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients hepatocellular carcinoma (HCC) previously treated sorafenib. In an exploratory study, we analyzed plasma and tumor samples from study participants to identify genetic, microRNA (miRNA), protein biomarkers associated response regorafenib.MethodsWe obtained archived tissues baseline HCC given the RESORCE trial. Baseline 499 were for expression of 294 proteins (DiscoveryMAP)...
<h3>Importance</h3> Low serum 25-hydroxyvitamin D (25[OH]D) levels are associated with an increased risk of multiple sclerosis (MS) as well disease activity and rate progression in clinically isolated syndromes early MS. <h3>Objective</h3> To assess the association between 25(OH)D course prognosis patients relapsing-remitting MS treated interferon beta-1b. <h3>Design, Setting, Participants</h3> We conducted a prospective cohort study assessing subsequent characterized by magnetic resonance...
d Genetic loss of TRAF3 is associated with
The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed breast cancer. However, its precise role disease etiology remains unknown. We analyzed more than 600 cancer tumor samples and circulating DNA for E17K alterations other cancer-associated genes using Beads, Emulsions, Amplification, Magnetics digital polymerase chain reaction technology targeted exome sequencing. Overall prevalence was 6.3 % not correlated age or menopausal...
Significance Human lymphomas and leukemias are characterized by molecular structural alterations of transcription factors (TFs). The identification such deregulated TFs is therefore central to the understanding lymphomagenesis. We addressed this question in classical Hodgkin lymphoma (HL), a common B-cell–derived malignancy that one most prominent examples for complex patterns including activation NF-κB or AP-1 profound deregulation lineage-specific TFs. found IRF5 together with induces...
Some previous studies suggest modest to strong effects of 25-hydroxyvitamin D (25(OH)D) on multiple sclerosis (MS) activity. The objective this study was explore the mechanistic rationale that may explain potential clinical 25(OH)D.This measured serum 25(OH)D levels and global gene expression profiles over a course up 2 years in patients starting treatment with interferon beta-1b (IFNB-1b) after clinically isolated syndrome. MS disease activity assessed by number gadolinium-enhancing lesions...
<h3>Objectives</h3> Anetumab ravtansine is an antibody-drug conjugate consisting of a fully human anti-mesothelin monoclonal antibody conjugated to cytotoxic maytansinoid tubulin inhibitor DM4. Mesothelin highly expressed in ovarian cancer. This phase Ib study determines the safety, pharmacokinetics, and anti-tumor activity anetumab pegylated liposomal doxorubicin mesothelin-expressing platinum-resistant <h3>Methods</h3> (5.5 or 6.5 mg/kg) (30 mg/m<sup>2</sup>) were administered...
The transcription factor E2A is essential for lymphocyte development. In this study, we describe a recurrent gene deletion in at least 70% of patients with Sézary syndrome (SS), subtype T cell lymphoma. Loss results enhanced proliferation and cycle progression via derepression the protooncogene MYC regulator CDK6. Furthermore, by examining expression profile SS cells after restoration expression, identify several E2A-regulated genes that interfere oncogenic signaling pathways, including Ras...
SummaryGTPases of immunity-associated proteins (GIMAPs) are regulators lymphocyte survival and homeostasis. We previously determined the structural basis GTP-dependent GIMAP2 scaffold formation on lipid droplets. To understand how its GTP hydrolysis is activated, we screened for other GIMAPs droplets identified GIMAP7. In contrast to GIMAP2, GIMAP7 displayed dimerization-stimulated hydrolysis. The crystal structure GTP-bound showed a homodimer that assembled via G domains, with helical...
The PI3K inhibitor copanlisib has efficacy and manageable safety in patients with indolent lymphoma solid tumors. Pharmacodynamic effects relative to dose plasma exposure were evaluated. Patients or tumors received 0.4 0.8 mg/kg on days 1, 8, 15 of a 28-day cycle. Primary variables maximum changes phosphorylated AKT (pAKT) levels platelet-rich (PRP) glucose. Other evaluations included signaling markers T-lymphocytes paired tumor biopsies, the relationship between estimated pharmacodynamic...
Significance Mature B cells are long-lived responsible for the Ab production in immune system. Canonical NF-κB signaling, one of two discrete pathways activating transcription factors family, participates generation a normal mature B-cell compartment. However, role these signals specifically is still imperfectly defined. Notably, their persistence follicular cells, main subset, controversial. Here, we show that canonical signaling does not contribute to immediate (short-term) survival...
Apart from its unique histopathological appearance with rare tumor cells embedded in an inflammatory background of bystander cells, classical Hodgkin lymphoma (cHL) is characterized by unusual activation a broad range signaling pathways involved cellular activation. This includes constitutive high-level activity nuclear factor-κB (NF-κB), Janus kinase/signal transducer and activator transcription (JAK/STAT), protein-1 (AP-1) interferon regulatory factor (IRF) factors (TFs) that are...
4078 Background: REG is a multikinase inhibitor which improved overall survival (OS; HR 0.63, 95% CI 0.50, 0.79; P<0.0001) and time to progression (TTP; 0.44, 0.36, 0.55; compared with placebo in patients HCC who progressed during prior sorafenib treatment the RESORCE trial. This exploratory analysis evaluated impact of baseline AFP c-Met on benefit (OS TTP) Methods: Circulating protein (shed ectodomain) levels were quantified by Luminex assay (Myriad RBM) plasma samples collected at from...