A5010519402- Pharmacological Receptor Mechanisms and Effects
- interferon and immune responses
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- Bipolar Disorder and Treatment
- Synthesis of Organic Compounds
- Inflammasome and immune disorders
- Viral Infections and Vectors
- Cancer-related Molecular Pathways
- Chemical synthesis and alkaloids
- NF-κB Signaling Pathways
- Phytochemistry and Bioactivity Studies
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Oxidative Organic Chemistry Reactions
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Cyclopropane Reaction Mechanisms
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
Jiangsu University
2021-2024
Xuzhou Medical College
2021-2024
China Pharmaceutical University
2017-2023
Affiliated Hospital of Jining Medical University
2020
State Key Laboratory of Natural Medicine
2018
Pudong New Area People's Hospital
2016
Tung Fang Design Institute
2004
Academia Sinica
1992
Academy of Medical Sciences
1992
Activation of the stimulator interferon genes (STING) pathway to achieve antitumor response is an attractive approach for cancer immunotherapy. In this study, we report identification BSP16 (LF250) as a potent, orally available STING agonist. strongly activates signaling in human and mouse cells binds homodimer. A 2.4 Å cocrystal structure revealed that could induce "closed" conformation STING. vivo studies well tolerated, has excellent pharmacokinetic profile oral drug, induces tumor...
The first photoactivatable STING agonist, caged-diBSP01, is presented based on a novel and potent dimerized agonist diBSP01. Caged-diBSP01 allowed spatiotemporal control of activation by light, which was well characterized both in vitro vivo .
Hexokinase 2 (HK2) has been identified as an oncogene in some malignant diseases such breast cancer and ovarian cancer. However, the role of HK2 lung remains unclear. In this study, we explored functional cell proliferation tumorigenesis determine its expression profile was increased primary tissues patients. Knocking down by small interfering RNA (siRNA) inhibited cells nude mice. Thus, is required for sustained survival tumor vitro vivo, aberrant may contribute to pathogenesis our study...
Cdc2-like kinases (CLKs; CLK1-4) are associated with various neurodegenerative disorders, metabolic regulation, and viral infection have been recognized as potential drug targets. Human CLK2 has received increasing attention a regulator that phosphorylates serine- arginine-rich (SR) proteins subsequently modulates the alternative splicing of precursor mRNA (pre-mRNA), which is an attractive target for degenerative disease cancer. Numerous inhibitors identified, several molecules currently in...
An efficient reaction utilizing propargyl carbonates through Claisen rearrangement to synthesize furanonaphthoquinones is described. The remarkable transformation exhibits excellent functional group tolerance, affording the target in moderate good yields (41–85%) under mild conditions. Scaled-up preparation of model product can make this a method choice for synthesis furanonaphthoquinone derivatives. resulting were evaluated as potential indoleamine 2,3-dioxygenase inhibitors vitro.
Recent studies have revealed that circular RNA participates in endometrial carcinoma (EC) progression. Here we investigated the role of circRNA zinc finger protein 124 (circZNF124) EC genesis and underlying mechanism.The expression levels circZNF124, microRNA-199b-5p (miR-199b-5p) solute carrier family 7 member 5 (SLC7A5) were detected by quantitative real-time polymerase chain reaction. The SLC7A5 other indicated marker proteins was determined western blot analysis. For functional assay,...
An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening scale-up preparation have also been accomplished, selected compounds were evaluated their photophysical properties.
Cervical cancer (CC) is one of the most common gynecological malignancies in world and poses a great threat to public health. There inadequate knowledge molecular mechanisms underlying CC. This study aimed explore prognostic value KIAA1429 (VIRMA, vir-Like m6A methyltransferase associated) patients with CC analyze its mechanisms. The level tumor specimens was tested using RT-qPCR western blotting. Cellular biological processes were assessed CCK-8 Transwell assays. Xenograft experiments used...
EIDD-2801 is an orally bioavailable prodrug, which will be applied for emergency use authorization from the U.S. Food and Drug Administration treatment of COVID-19. To investigate optimal parameters, was optimized
Abstract Background: Chemoresistance is an important cause of malignant progression esophageal squamous cell carcinomas (ESCCs). miR-378d sharply reduced in paclitaxel (PTX)-resistance cancer cells by gene-expression profile analysis (RNA-Seq), but the mechanism miR-378d-mediated tumor unclear. Patients and methods: Herein, we detected expression 596 ESCC patients situ hybridization. Results showed that low was associated with poor prognosis patients, absence enhanced carcinogenesis...