A5056183538- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Superconductivity in MgB2 and Alloys
- Analytical Methods in Pharmaceuticals
- Pharmacy and Medical Practices
- Pharmacovigilance and Adverse Drug Reactions
- Physics of Superconductivity and Magnetism
- Crystallography and molecular interactions
- Antibiotics Pharmacokinetics and Efficacy
- Medicinal Plants and Neuroprotection
- GDF15 and Related Biomarkers
- Pharmacological Effects and Toxicity Studies
- Nanoparticles: synthesis and applications
- Pharmaceutical studies and practices
- Innovations in Concrete and Construction Materials
- Fungal Infections and Studies
- Adenosine and Purinergic Signaling
- Analytical Chemistry and Chromatography
- Iron-based superconductors research
- Drug Transport and Resistance Mechanisms
- Natural Fiber Reinforced Composites
- Boron and Carbon Nanomaterials Research
- Immune cells in cancer
Beijing Institute of Technology
2021-2024
Infrastructure University Kuala Lumpur
2010-2022
Jilin University
2007-2020
Jilin Medical University
2019-2020
Zhejiang University
2019
First Affiliated Hospital Zhejiang University
2019
Taiyuan University of Technology
2019
Peking University
2018
Second Military Medical University
2015
Changhai Hospital
2015
Background: Obesity plays crucial roles in the development of cardiovascular diseases. However, mechanisms that link obesity and diseases remain elusive. Compelling evidence indicates adipokines play an important role obesity-related Here, we found a new adipokine-named family with sequence similarity 19, member A5 (FAM19A5), protein unknown function was predicted to be distantly related CC-chemokine family. We aimed test whether adipose-derived FAM19A5 regulates vascular pathology on...
The depletion of natural resources due to the aggressive industrialization in last decades has brought considerable attention research aimed at developing green and sustainable products using eco-friendly materials. purpose current study was develop wood polymer composites (WPCs) recycled plastic waste (RPW) generated from university laboratories (RWW) construction demolition (C&D) activities by melt-blending technique. WPCs were characterised for their mechanical thermal properties, as...
Investigation of targeting inhibitors Aβ aggregation, heme-Aβ peroxidase-like activity and efficient detectors are therapeutic value diagnostics significance for the treatment Alzheimer's disease (AD).Due to complex pathogenesis AD, theranostics with multiple functions necessary.Herein we constructed NIR absorption property gold nanorods (GNRs) loaded single chain variable fragment (scFv) 12B4 thermophilic acylpeptide hydrolase (APH) ST0779 as a smart theranostic (GNRs-APH-scFv, GAS), which...
Abstract Regulation of neuroinflammation and β‐amyloid (Aβ) production are critical factors in the pathogenesis Alzheimer's disease (AD). Cathepsin E (CatE), an aspartic protease, is widely studied as inducer growth arrest apoptosis several types cancer cells. However, function CatE AD unknown. In this study, we demonstrated that ablation human amyloid precursor protein knock‐in mice, called APP NL−G−F significantly reduced Aβ accumulation, neuroinflammation, cognitive impairments....
Amoxicillin and cefaclor are two of the widely used β-lactam antibiotics in treatment urinary tract infections. Both drugs eliminated mainly by kidney rely on renal excretion to exert their antibacterial activities tract. Previous studies have suggested involvement organic anion oligopeptide transporters membrane transport β-lactams. The objective current study was examine kinetics amoxicillin interactions with human transporter 1 (hOAT1), peptide (hPepT1), 2 (hPepT2) detail, both as...
The use of biodegradable polymers in daily life is increasing to reduce environmental hazards. In line with this, the present study aimed develop a fully polymer composite that was environmentally friendly and exhibited promising mechanical thermal properties. Bamboo powder (BP)-reinforced polycaprolactone (PCL) composites were prepared using solvent casting method. influence BP content on morphology, wettability, properties neat matrix evaluated. addition, degradation analysed through soil...
Cu(ii) ions are one of the most common forms copper present in water and can cause bioaccumulation toxicity human body; therefore, sensitive selective detection methods required. Herein, a ion sensor based on UiO-66-NH
Preparation of well-dispersed ZnO nanograins is necessary to improve their reactivity toward room-temperature H2S removal. However, the challenge design such a ZnO-based adsorbent with high loading yet be fulfilled. Herein, facile sol–gel strategy reported for preparation ZnO/SiO2 adsorbents efficient removal, by innovating gel-drying method and simultaneously controlling grain formation through optimizing molar ratio ethylene glycol (EG)/nitrates in its precursors. The fabricated embedded...
The aim of this study was to explore the use urantide as an antagonist urotensin II (UII) receptor, G protein-coupled receptor 14 (GPR14), protect against atherosclerosis (AS) in rats. AS rat model induced by intraperitoneal injection vitamin D3 (VD3) into rats fed with a high-fat diet for four weeks. Urantide then injected Immunohistochemical staining, serum biochemical assay, reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were used investigate expression UII...
Cryptococcus neoformans infections are becoming increasingly prevalent and remain a life-threatening clinical issue in immune-compromised hosts. The microorganism evades variety of endogenous anti-fungal mechanims host immune cells. signaling pathways human cells that become activated response to infection have yet be fully characterized.Human monocytes were incubated with neoformans, the whole transcriptome was sequenced before after exposure using mass parallel sequencing techniques. Based...
Zinc finger protein 335 (Zfp335) is a transcription factor that regulates mammalian neurogenesis and neuronal differentiation. It causative for severe microcephaly, small somatic size, neonatal death. Here, we evaluated the effects of Zfp335 in adult mouse brain after lipopolysaccharide (LPS) challenge. We used wild-type (WT) knock-down (Zfp335+/- ) mice with LPS administered intracerebral ventricle vivo cultured microglia treated vitro. The impact was by RT-PCR, RNA-sequencing, western...
Graphene has gained tremendous attention due to its unlimited potential in various applications while poly(lactic acid) (PLA) is a biodegradable thermoplastic polyester produced from fermenting corn starch. The incorporation of graphene into PLA been proven exhibit excellent mechanical and thermal properties. However, there are not many reports on the toxic effect these materials towards living organisms. In this study, we investigated possible toxicity PLA-graphene live animal model,...
Mice co-expressing human amyloid precursor protein with the Swedish mutation (APPswe) and exon-9-deleted presenilin (PS1dE9) has become one of most widely used mouse models for studying Alzheimer's disease (AD) pathogenesis preclinical studies AD therapeutic approaches.In this study, we systematically investigated cognitive decline, amyloid-β (Aβ) deposition cerebral or Aβ serum levels as well relationships among these measures in APPswe/PS1dE9 transgenic mice.APPswe/PS1dE9 mice were...
Toll-like receptors are the most important pattern recognition that can recognize conserved molecular structures shared by large groups of pathogens. Here, aim was to determine expression and role TLR2 in peripheral blood mononuclear cells (PBMCs) from patients with cryptococcal meningitis healthy controls. measured using RT-PCR western blotting. The cytokine production PBMCs after Cryptococcus neoformans exposure assessed controls prior incubation anti-TLR2. mRNA protein were both weaker...
The effects of NiO nanoparticles addition in YBa 2 Cu 3 O 7- δ (YBCO) superconductors had been investigated. YBCO superconductor powders were prepared by using high purity oxide via solid state reaction method. 0.01 0.05 wt.% added into YBCO. critical temperature ( T c ) and transport current density J determined four point probe lattice parameters morphology the samples characterized X-ray diffraction (XRD) Scanning Electron Microscopy (SEM), respectively. increased from 84 K to 87 with...