A5043140752- Analytical Chemistry and Chromatography
- Gout, Hyperuricemia, Uric Acid
- Analytical Methods in Pharmaceuticals
- Gastrointestinal motility and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Rheumatoid Arthritis Research and Therapies
- Pharmacy and Medical Practices
- Cancer, Lipids, and Metabolism
- Case Reports on Hematomas
- Cancer Treatment and Pharmacology
- Eosinophilic Disorders and Syndromes
- Dementia and Cognitive Impairment Research
- Drug-Induced Adverse Reactions
- Dental Health and Care Utilization
- Nicotinic Acetylcholine Receptors Study
- Chronic Lymphocytic Leukemia Research
- Organophosphorus compounds synthesis
- Smoking Behavior and Cessation
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacological Effects and Assays
- Pneumonia and Respiratory Infections
- Complementary and Alternative Medicine Studies
- Immunodeficiency and Autoimmune Disorders
- Bone health and treatments
Kaohsiung Medical University
2003-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Kaohsiung Chang Gung Memorial Hospital
2017
Bridge University
2016
Deyang Stomatological Hospital
2009
A simple and sensitive high-performance liquid chromatographic method is described for the quantitative analysis of ciprofloxacin in pharmaceuticals human plasma. The employs reversed-phase chromatography using an RP-C18 column with isocratic mobile phase acetonitrile-2% acetic acid aqueous solution (16:84, v/v), umbelliferone as internal standard, a flow rate 1.0 mL/min. UV detector set at 280 nm. limit detection 0.25 microM (S/N = 3, injection volume 10 microL). regression equations are...
Objective. Patients with an HLA-B*58:01 allele have increased risk of developing severe cutaneous adverse drug reactions (SCAR) when treated allopurinol. Although one-off pharmacogenetic testing may prevent life-threatening reactions, prior to allopurinol initiation incurs additional costs. The study objective was evaluate the cost-effectiveness screening compared using other available urate-lowering agents (ULA). Methods. A decision-analytical model used compare direct medical costs and...
Abstract Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings unclear. This study aimed compare febuxostat allopurinol for uric acid reduction and renal protection patients CKD. Adult CKD newly treated ULT were identified using electronic health records from 2010 2015 a large healthcare delivery system Taiwan. Patients replacement or undergoing <3 months excluded. Propensity...
Dementia is one of the most disabling and burdensome health conditions worldwide. In this study, we identified new potential risk factors for dementia from nationwide longitudinal population-based data by using Bayesian statistics. We first tested consistency results obtained statistics with those classical frequentist probability 4 recognized dementia, namely severe head injury, depression, diabetes mellitus, vascular diseases. Then, used to verify 2 hearing loss senile cataract, determined...
Abstract A capillary gas chromatographic method is described for the determination of perindopril, an anti-hypertensive agent. The based on derivatization perindopril with pentafluorobenzyl bromide in acetone, using potassium carbonate as a base catalyst. Under mild condition, highly polar and nonvolatile was derivatized into derivative suitable properties. resulting separated SE-54 column detected by flame-ionization detector. Several parameters affecting were investigated. linear range...
Human leukocyte antigen (HLA-B*58:01) allele screening before allopurinol administration is recommended to prevent gene-mediated severe cutaneous adverse reactions (SCARs). The objective of the analysis was examine clinical utility and effects HLA-B*58:01 genotyping on patient's outcomes in a practice setting.The electronic medical records covering diagnosis, laboratory results, prescription dispensing for patients who were newly treated with or tested obtained from large organization Taiwan...
Behçet's disease (BD) is a recurrent, multisystemic, inflammatory disorder that mainly affects blood vessels. Because recurrent inflammation of vessels in the brain plays crucial role development ischemic stroke, we hypothesized patients with BD might have an elevated risk stroke. This potential association has been suggested few case reports, but not epidemiological studies. Hence, present study aimed to examine relation between and subsequent stroke Taiwan using nationwide,...
Patients with rheumatic disease are at risk for infections. Evaluating antitumour necrosis factor (anti-TNF) drug-associated of infections requires justification baseline in the population high infection. We examined incidence active tuberculosis (TB) and its factors patients started anti-TNF-α therapy or existing disease-modifying antirheumatic drug (DMARD) therapy.A retrospective cohort study new users (anti-TNF-α group) those starting a DMARD after failure least one other who had added to...
Objectives Changes in treatment choice of therapy and size treated population that can lead to under- or overestimate payer’s budget are less likely be reassured after reimbursement adoption a new drug. The aim this study was evaluate the effects febuxostat introduction modifications its insurance coverage on utilization expenditure urate-lowering (ULT). Methods Electronic medical records for adults patients prescribed any ULT during 2010–2015 derived from largest organization Taiwan....
A risk management plan (RMP) was introduced to monitor the association between initiation of antitumor necrosis factor-α (anti-TNF-α) therapy and tuberculosis (TB) viral hepatitis infections. The aim this study assess adherence predictors laboratory-testing rates among patients treated with anti-TNF-α therapy.Data on receiving January 1, 2005, November 31, 2013, were retrieved from a large medical organization in Taiwan. Newly-treated categorized into pre- post-RMP groups. Laboratory testing...
Dengue fever (DF) is the most rapidly spreading mosquito-borne viral disease. Practical vaccines or specific therapeutics are still expected. Environmental factors and genetic affect susceptibility of virus (DV) infection. Asthma a common allergic disease, with house dust mites (HDMs) being important allergens. Asthmatic patients susceptible to several microorganism infections. A nationwide population-based cohort analysis was designed assess whether determine asthma can be risk factor for...
Dementia is one of the most burdensome illnesses in elderly populations worldwide. However, literature about multiple risk factors for dementia scant. To develop a simple, rapid, and appropriate predictive tool clinical quantitative assessment dementia. A population-based cohort study. Based on Taiwan National Health Insurance Research Database, participants first diagnosed with from 2000 to 2009 aged ≥65 years were included. logistic regression model Bayesian supervised learning inference...
Objective: To investigate the association between total cholesterol (TC) and primary liver cancer in Chinese males. Methods: Since May 2006, all male workers, including employees retirees Kailuan Group were recruited dynamic cohort study. Information about demographics, medical history TC levels was collected at baseline interview, as well information on newly-diagnosed cases during follow-up period. A of 110 612 males by 31 December 2015. divided into four categories quartile (<4.27,...
Abstract A simple and specific high performance liquid chromatographic (HPLC) method is described for the determination of R-(+)- S-(−)acebutolols. The based on derivatization hydroxyl amino functions acebutolol with N-benzyloxycarbonyl-L-phenyl-alanine acetic anhydride, respectively. resulting derivatives were separated a reversed phase C-18 column monitored UV detector, leading to base line resolution diastereomeric S-(−) R-(+) acebutolols.
Abstract High performance liquid chromatography (HPLC) with chemically removable derivatizing reagents for the analysis of methanol has been developed. Methanol was derivatized 4-[N-methyl, N-(1-naphthylmethyl)]-amino-4-oxo-butanoic acid (NAOB), using 4-dimethylaminopyridine (DMAP) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as activators. NAOB activators are can be removed by aqueous base treatment after derivatization to minimize reagent interference in...
Abstract An improved and sensitive gas chromatographic method has been established for the determination of four dialkyl thiophosphates including dimethyl phosphorothioate, diethyl phosphorodithioate phosphorodithioate. The is based on derivatization with pentafluorobenzyl bromide, using hexadecyltrimethylammonium bromide as a phase transfer catalyst. resulting derivatives were separated an SE-54 capillary column detected by electron-capture detector. Several parameters affecting related...
目的：藉由藥師居家訪視評估臺北縣個案的用藥情形，針對用藥問題給予專業的諮詢及指導，並統計分析其結果，做為日後藥師提供長期照護居家個案用藥諮詢服務之參考。方法：以2010年1月1日至12月31日，整理個案的訪視資料「臺北縣政府長期照顧服務個案評估量表」，經個案同意後，藥師進行訪視和填寫「用藥紀錄及用藥適當性評估」。探討個案基本資料、罹病分布及用藥情形，並分析其接受藥師訪視之情形。結果：個案經藥師訪視分別有一、二、三次，依序為206、84、21人。六成領有身心障礙手冊，以重度最多。ADL平均46.1分。就診科別最多為神經科，藥物用量最多為nervous system, cardiovascular alimentarytract and metabolism，疾病以高血壓、心臟病及糖尿病居多。接受藥師訪視一次及二次的身心障礙等級（p = 0.041）及ADL 分組（p...