A5058784758- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Radio Astronomy Observations and Technology
- Pulsars and Gravitational Waves Research
- Astronomy and Astrophysical Research
- Data Management and Algorithms
- Geophysics and Gravity Measurements
- Cloud Computing and Resource Management
- Astronomical Observations and Instrumentation
- Drug Transport and Resistance Mechanisms
- Crystallization and Solubility Studies
- Stellar, planetary, and galactic studies
- Peer-to-Peer Network Technologies
- Advanced Data Storage Technologies
- Machine Learning in Bioinformatics
- Catalytic C–H Functionalization Methods
- Graph Theory and Algorithms
- Neutropenia and Cancer Infections
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- Cancer Treatment and Pharmacology
- X-ray Diffraction in Crystallography
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Galaxies: Formation, Evolution, Phenomena
Peking Union Medical College Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
University of Electronic Science and Technology of China
2023-2024
Guizhou University
2023
National Astronomical Observatories
2015-2023
Nankai University
2022-2023
Chengdu University
2020-2022
Sichuan University
2020-2022
Chinese Academy of Sciences
2015-2021
Huazhong University of Science and Technology
2020
Observing and timing a group of millisecond pulsars (MSPs) with high rotational stability enables the direct detection gravitational waves (GWs). The GW signals can be identified from spatial correlations encoded in times-of-arrival widely spaced pulsar-pairs. Chinese Pulsar Timing Array (CPTA) is collaboration aiming at observations carried out using radio telescopes. This short article serves as `table contents' for forthcoming series papers related to CPTA Data Release 1 (CPTA DR1) which...
Rationale: Immune checkpoint (ICP) blockade therapy combined with chemotherapy is a promising treatment strategy for tumors. Chemotherapeutic agents usually function inside the tumor cells, while ICP inhibitors are efficacious out of cells. It desirable to effectively co-deliver an inhibitor and agent different sites tumor. We have designed effective drug delivery system accomplish both objectives. Methods: Pickering nanoemulsion (PNE) using multi-sensitive nanogels pH-responsive,...
Chiral propargylic boron compounds have a diverse array of potential applications. Although numbers highly enantioselective methodologies for the synthesis other organoboron are well established, chiral remains unknown. Herein, we report catalytic method construction by means dirhodium-catalyzed B–H bond insertion reactions using aryl sulfonylhydrazones as carbene precursors. This enables straightforward wide range stable in yields up to 99% with enantioselectivities 97% ee. The...
We present polarization pulse profiles for 56 millisecond pulsars (MSPs) monitored by the Chinese Pulsar Timing Array (CPTA) collaboration using Five-hundred-meter Aperture Spherical radio Telescope (FAST). The observations centered at 1.25 GHz with a raw bandwidth of 500 MHz. Due to high sensitivity (∼16 K/Jy) FAST telescope and our long integration time, signal-to-noise ratio show features hardly detected before. Among pulsars, PSRs J0406$+$3039, J1327$+$3423, J2022$+$2534 were not...
The objective of the study is to investigate whether multiple chemotherapeutic agent-related genetic polymorphisms are associated with clinical outcomes Taiwanese metastatic colorectal cancers (mCRC) patients treated first-line FOLFOX-4 chemotherapy.Consecutive mCRC were prospectively enrolled into this study. Peripheral blood samples used for genotyping in MTHFR, DPD, GSTP1, MDR1, TYMS, ERCC1, XRCC1, and ERCC2 genes by polymerase chain reaction-restriction fragment length polymorphism...
This study aimed to identify the efficacy and toxicity of FOLFIRI regimen (fluorouracil, leucovorin, irinotecan) with irinotecan dose escalation plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer (mCRC) via UGT1A1 genotyping.We administered treat 70 mCRC patients. The *1/*1 *1/*28 genotypes started a 180-mg/m(2) irinotecan, *28/*28 genotype 120 mg/m(2). was escalated at increasing intervals 20 30 mg/m(2) until grade 3/4 adverse events (AEs) occurred. clinical...
Exploring efficient and high-accuracy computational drug repositioning methods has become a popular attractive topic in development. This technology can systematically identify potential drug-disease interactions, which could greatly alleviate the pressures from high cost long period taken by traditional research discovery. However, plenty of current approaches lack interpretability predicting associations, will not be friendly to their subsequent in-depth research. To this end, we hereby...
Chiral fluorinated reagents provide new opportunities for the discovery of drugs and functional materials because introduction a group significantly alters molecule's physicochemical properties. gem-difluoroalkyl fragments (R-CF2-C*) are key motifs in many drugs. However, scarcity synthetic methods types chiral limits applications these compounds. Herein, we report two propargylic borons α-allenols their synthesis by means involving rhodium-catalyzed enantioselective B-H bond insertion...
Abstract Background: Adverse drug events (ADE) have been studied widely in hospitalised and emergency department (ED) patients. Less is known about the ED visits of drug‐related injury Taiwan. This study seeks to determine incidence, risk patient outcomes ADE an population. Methods: We conducted a prospective observational cohort patients 18 years older presenting urban, tertiary medical centre. between 1 March 2009 28 February 2010 identified by investigators for suspected were further...
ABSTRACT We present a pilot study of extragalactic H i 21-cm absorption lines using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). observed five continuum sources with features first identified in 40 per cent data release Arecibo Legacy Fast L-Band Feed Array (ALFA) Survey (ALFALFA), including two systems later detected by Westerbork Synthesis Radio (WSRT). Most our observations were carried out during FAST commissioning phase, and we have tested different observing modes,...
High-sensitivity C-reactive protein (hs-CRP) concentrations and obesity are proposed to have a significant relationship with impairment of lung function, but little has been reported date on the association between CRP gene function. We studied three tagSNPs (tag single nucleotide polymorphisms) their interactions central A total 384 asthmatic adults controls who were 1:1 matched by sex age recruited for this study. Three polymorphisms rs1417938, rs1800947 rs1205 selected from HapMap data...
Using the comprehensive approach to selecting polymorphisms date, we sought examine whether recurrence in colorectal cancer was associated with inherited variation three genes involved DNA repair and cell proliferation. Three polymorphisms, which are excision cross-complementation 1 (ERCC1), xeroderma pigmentosum group D (XPD) epidermal growth factor receptor (EGFR), were assessed 257 postoperative stage II/III CRC patients 5-fluorouracial chemotherapy Taiwan. In addition, correlations...
We report the discovery of a highly dispersed fast radio burst, FRB~181123, from an analysis $\sim$1500~hr drift-scan survey data taken using Five-hundred-meter Aperture Spherical Telescope (FAST). The pulse has three distinct emission components, which vary with frequency across our 1.0--1.5~GHz observing band. measure peak flux density to be $>0.065$~Jy and corresponding fluence $>0.2$~Jy~ms. Based on observed dispersion 1812~cm$^{-3}$~pc, we infer redshift $\sim 1.9$. From this, estimate...
Rationale: The perivascular epithelioid cell tumor (PEComa) is rare in young man and rarely occurs the large intestine. Patient concerns: clinical characteristics, diagnosis, managements a 28-year-old boy who presented with sudden onset of cramping abdominal pain intermittent melena blood pressure 74/39 mm Hg was retrospectively reviewed. CT scan abdomen revealed 8.9 × 7.2 cm mass pelvic floor. Diagnoses: Given difficulty obtaining diagnostic specimen, surgical resection performed. pathology...
A dielectric filter utilizing polyamide-imide (PAI) as the substrate exhibits a promising application potential in field of high-frequency microwave communication with advantages smaller volume and lighter weight, while achieving metallization PAI remains challenge. In this paper, facile effective method for synthesizing high-adhesion low-resistivity copper layer on via coating modification electroless plating (ECP) is demonstrated. Through chemical etching alkaline potassium permanganate...
<b><i>Objective:</i></b> To report a metastatic colorectal cancer patient with hyperbilirubinemia treated combination of bevacizumab and FOLFIRI (5-fluorouracil, leucovorin, irinotecan) using uridine diphosphate glucuronosyl transferase<i> (UGT1A1)</i> genotyping. <b><i>Clinical Presentation Intervention:</i></b> A 46-year-old male was diagnosed rectosigmoid colon liver metastases presenting severe jaundice. <i>UGT1A1...
The optimal timing for laparoscopic cholecystectomy (LC) in acute cholecystitis (AC) remains controversial. In this study, we aggressively performed three types of LC techniques AC patients at different time with our care procedure.Forty-three were retrospectively divided into two groups: Group one (n=16, within 72 hrs the onset symptoms) and (n=27, beyond after symptoms). Standard, subtotal or prograde all cases, depending on fragility gallbladder wall, difficulty dissection, assurance...