A5101991039- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Advanced Photocatalysis Techniques
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Membrane Separation Technologies
- Hepatitis B Virus Studies
- Membrane-based Ion Separation Techniques
- Luminescence and Fluorescent Materials
- Photovoltaic System Optimization Techniques
- Advanced Battery Technologies Research
- Advanced Sensor and Energy Harvesting Materials
- Advancements in Battery Materials
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Microgrid Control and Optimization
- Pickering emulsions and particle stabilization
- Electrospun Nanofibers in Biomedical Applications
- Autophagy in Disease and Therapy
- Advanced Nanomaterials in Catalysis
Second Hospital of Anhui Medical University
2023-2025
Anhui Medical University
2023-2025
Huazhong University of Science and Technology
2015-2024
National Engineering Research Center for Nanotechnology
2017-2024
Wuhan Technology and Business University
2024
Nanjing Tech University
2024
Ningxia Normal University
2023
Union Hospital
2016-2023
University of Maryland, College Park
2013-2021
Southwest Minzu University
2021
Abstract Tissue engineering heart valves (TEHVs) are expected to address the limitations of mechanical and bioprosthetic used in clinical practice. Decellularized valve (DHV) is an important scaffold TEHVs due its natural three‐dimensional structure bioactive extracellular matrix, but properties hemocompatibility impaired. In this study, DHV cross‐linked with three different molecular weights oxidized hyaluronic acid (OHA) by a Schiff base reaction presented enhanced stability...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, has been spreading globally. We aimed to develop a clinical model predict the outcome of patients with COVID-19 infection early.Demographic, and first laboratory findings after admission 183 (115 survivors 68 non-survivors from Sino-French New City Branch Tongji Hospital, Wuhan) were used predictive models. Machine learning approaches select features patients' outcomes. The area under...
Efficient accumulation and intracellular drug release in cancer cells remain a crucial challenge developing ideal anticancer delivery systems. Here, poly(N-isopropylacrylamide)-ss-acrylic acid (P(NIPAM-ss-AA)) nanogels based on NIPAM AA cross-linked by N,N'-bis(acryloyl)cystamine (BAC) were constructed precipitation polymerization. The exhibited pH/redox dual responsive doxorubicin (DOX) behavior vitro tumor cells, which DOX from was accelerated lysosomal pH (pH 4.5) cytosolic reduction (10...
Reconciling the conflicting needs for a prolonged circulation time, enhanced cellular uptake by bulk tumor cells and cancer stem (CSCs), extensive tissue penetration remains major challenge current nano drug delivery systems. Here we describe smart poly(N-isopropylacrylamide)-based nanogels with fast adaptive hydrophobicity to solve these contradictory requirements chemotherapy. The are hydrophilic in blood prolong their time. Once they accumulate at sites, rapidly become hydrophobic...
Abstract Low vaccine immunogenicity and tumor heterogenicity greatly limit the therapeutic effect of vaccine. In this study, a novel injectable adhesive hydrogel, based on thermosensitive nanogels containing catechol groups loaded with in situ‐forming MnO 2 nanoparticles, is constructed to overcome these issues. The concentrated nanogel dispersion transforms into an hydrogel situ after intratumoral injection. photothermal nanoparticles induces immunogenic cell death release mass autologous...
Magnetic thermosensitive ionic nanogels were prepared based on strong monomer AMPS and NIPAM <italic>via</italic> precipitation polymerization in the presence of Fe<sub>3</sub>O<sub>4</sub> nanoparticles investigated as draw solutes FO.
The lack of noninvasive tracking and mapping the fate embolic agents has restricted development further applications transcatheter arterial embolization (TAE) therapy. In this work, inherent radiopaque material, barium alginate (ALG) microspheres loaded with in situ synthesized BaSO4 (denoted as BaSO4/ALG microspheres), have been by a one-step droplet microfluidic technique. One advantages our approach is that form nanoparticles well dispersed inside ALG microspheres, thereby greatly...
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading globally. The number of deaths increased with the increase in infected patients. We aimed to develop a clinical model predict outcome COVID-19 patients early. Methods Epidemiological, clinical, and first laboratory findings after admission 183 (115 survivors 68 nonsurvivors) from Sino-French New City Branch Tongji Hospital were used...
Soft photonic crystals (PC) are more appealing due to the responsiveness of building blocking-deformable nanoparticles external stimuli. In this report, we demonstrate, for first time, generation soft core/shell PC microspheres through a combination microfluidic technique, encapsulation well-ordered temperature responsive polymer nanogels suspension, and photopolymerization transparent shell resin. This strategy not only ensures monodispersity microspheres, but also precisely controls their...
Ideal anticancer nano drug delivery systems (NDDSs) need to overcome a series of physiological barriers including blood circulation, tumor accumulation, penetration, internalization by cancer cells, lysosomal escape, and on-demand intracellular release following systemic administration. However, it remains big challenge construct NDDSs that can all the at same time. Here, we develop zwitterionic temperature/redox-sensitive nanogels loaded with near-infrared (NIR) dye Indocyanine green (ICG)...
Abstract Fibroblast‐to‐myofibroblast differentiation, which is characterized by increased expression of α‐smooth muscle actin, known to be involved in the pathogenesis idiopathic pulmonary fibrosis. Sirtuin 6 (SIRT6), a member sirtuin family, has been proved inhibit epithelial‐to‐mesenchymal transition during However, function SIRT6 lung myofibroblast differentiation still obscure. Transforming growth factor‐β1 (TGF‐β1) one main factors that can powerfully promote differentiation. In current...
Rationale: Immune checkpoint (ICP) blockade therapy combined with chemotherapy is a promising treatment strategy for tumors. Chemotherapeutic agents usually function inside the tumor cells, while ICP inhibitors are efficacious out of cells. It desirable to effectively co-deliver an inhibitor and agent different sites tumor. We have designed effective drug delivery system accomplish both objectives. Methods: Pickering nanoemulsion (PNE) using multi-sensitive nanogels pH-responsive,...
Schematic presentation of Cu<sub>2</sub>O–CuO@GQD EHP fabrication and real-time detection bisphenol A in live cells.
Long circulation in the blood, efficient cellular internalization, and intracellular drug release tumor cells are major challenges development of ideal anticancer delivery systems. In this paper, hydrophilicity/hydrophobicity reversable redox-sensitive poly(oligo(ethylene glycol) methacrylates-ss-acrylic acid) (P(OEGMAs-ss-AA)) nanogels were constructed as carriers for cancer therapy. The underwent a pH-dependent hydrophilic/hydrophobic change. hydrophilic under physiological conditions (pH...