A5012708855- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
- DNA and Nucleic Acid Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Fiber Laser Technologies
- Advanced Photonic Communication Systems
- Molecular Sensors and Ion Detection
- Cancer Research and Treatments
- Advanced Fiber Optic Sensors
- Electrochemical sensors and biosensors
- Aquaculture Nutrition and Growth
- Blood Coagulation and Thrombosis Mechanisms
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Photonic and Optical Devices
- Monoclonal and Polyclonal Antibodies Research
- Nanocluster Synthesis and Applications
- Biosensors and Analytical Detection
Xuzhou Medical College
2025
Changzhou University
2015-2025
Huazhong University of Science and Technology
2015-2024
Nanjing Medical University
2024
First Hospital of Jiaxing
2021-2024
Nanjing University of Information Science and Technology
2017-2024
Jiangnan University
2023
Beijing Institute of Technology
2019-2023
Wuhu No 1 People's Hospital
2023
National Engineering Research Center for Nanotechnology
2019-2023
Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces...
A new kind of nitrogen-rich triptycene-based porous polymer (NTP) with high surface area up to 1067 m2 g-1 was synthesized by a modified Yamamoto-type Ullmann cross-coupling reaction. Having structure features expanded conjugated and nitrogen atoms doping in networks, the NTP displays extraordinary gas storage ability excellent iodine adsorption capability.
The poor performance of 2014-15 Northern Hemisphere (NH) influenza vaccines was attributed to mismatched H3N2 component with circulating epidemic strains. Using human serum samples collected from 2009-10, 2010-11 and NH vaccine trials, we assessed their cross-reactive hemagglutination inhibition (HAI) antibody responses against recent H3 isolates. All three populations (children, adults, older adults) vaccinated the egg- or cell-based vaccine, showed >50% reduction in HAI post-vaccination...
With only graphene oxide and KMnO4, the luminescent quantum dots (GQDs) in high yield were prepared by one-step synthesis using ultrasonication, applied label-free, simple fast fluorescence assay of alkaline phosphatase (ALP).
Abstract Low vaccine immunogenicity and tumor heterogenicity greatly limit the therapeutic effect of vaccine. In this study, a novel injectable adhesive hydrogel, based on thermosensitive nanogels containing catechol groups loaded with in situ‐forming MnO 2 nanoparticles, is constructed to overcome these issues. The concentrated nanogel dispersion transforms into an hydrogel situ after intratumoral injection. photothermal nanoparticles induces immunogenic cell death release mass autologous...
Certain anaerobic microbes with the capability to colonize tumor microenvironment tend express heterologous gene in a sustainable manner, which will inevitably compromise therapeutic efficacy and induce off-tumor toxicity vivo. To improve precision controllability of bacteria-based therapeutics, Escherichia coli Nissle 1917 (EcN), engineered sense blue light release encoded flagellin B (flaB), is conjugated lanthanide upconversion nanoparticles (UCNPs) for near-infrared (NIR)...
Platelet-rich thrombi are resistant to lysis by tissue plasminogen activator (tPA). Plasminogen inhibitor-1 (PAI-1), a rapid inhibitor of tPA, may contribute arterial thrombolysis resistance. However, few data available regarding the effect PAI-1 on in animals. We used murine carotid injury model test hypothesis that inhibits mediated pharmacological concentrations tPA.Platelet-rich were induced wild-type mice (PAI-1 +/+; n=11) and PAI-1-deficient -/-; with ferric chloride. Baseline blood...
To investigate the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI-deficient mice by targeted gene disruption. Intercrossing heterozygous TAFI produced offspring expected Mendelian ratio, indicating that transmission mutant allele did not lead to embryonic lethality. developed normally, reached adulthood, and were fertile. No gross physical abnormalities observed up 24 months age. Hematological analysis show any major differences...
With exonuclease III activity on DNA hybrids containing thymine–Hg2+–thymine, a label-free ultrasensitive "turn-on" fluorescent sensor involving "quenching" and "reappearing" processes based carbon nanotube–Ag nanoclusters system is demonstrated for amplified determination of Hg2+.
Hypoxia is a fundamental hallmark of solid tumors and helps contribute to chemotherapy resistance. Hyperbaric oxygen (HBO) therapy can overcome tumor hypoxia promote antitumor efficacy; however, the simultaneous administration some conventional chemotherapies, including doxorubicin (DOX), with HBO considered an absolute contraindication. Here, DOX-loaded liposome (Doxil) coadministered assess safety efficacy this combination treatment. By overcoming hypoxia, not only improves Doxil...
Photodynamic therapy (PDT) holds great promise as a noninvasive and selective cancer therapeutic treatment in preclinical research clinical practice; however, it has limited efficacy the ablation of deep-seated tumor because hypoxia-associated circumstance poor penetration photosensitizers to cells away from blood vessels. To tackle obstacles, we propose strategy that synergizes upconversion nanophotosensitizers (UNPSs) with hyperbaric oxygen (HBO) remodel extracellular matrix for enhanced...
Two cases of lanthanide (Ln)-implanted arsenotungstates, K17Na2H5[{(As2W19O67(H2O))Ln(H2O)2}2(C2O4)]·87H2O (Ln = Eu (1), Ln Tb (2)) and their codoped derivatives EuxTb1-x-POM (x 0.01 (3), x 0.04 (4), 0.1 (5), 0.2 (6)) were prepared further characterized by powder X-ray diffraction, infrared spectra, thermogravimetric analyses. An structural analysis 1 2 indicates that they both present a dimeric oxalate-bridged Ln3+-implanted arsenotungstate polyanion structure. Under the O → W LMCT...
To investigate the consequence of deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI), we generated homozygous TAFI-deficient mice by targeted gene disruption. Intercrossing heterozygous TAFI produced offspring expected Mendelian ratio, indicating that transmission mutant allele did not lead to embryonic lethality. developed normally, reached adulthood, and were fertile. No gross physical abnormalities observed up 24 months age. Hematological analysis show any major differences...
Abstract Poly(amidoamine) (PAMAM) dendrimers are widely used in medical applications. However, bearing positively charged surface groups prone to destabilize cell membrane and cause lysis. The lytic effect of on red blood cells (RBCs) namely hemolysis is extremely dangerous when administered vivo . To diminish the hematologic toxicity, we modified PAMAM with poly(ethylene glycol) (PEG) three molecular weights (2k, 5k, 20k). protective PEGylation against dendrimer‐induced was studied. RBCs...