A5081337109- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Animal Disease Management and Epidemiology
- Immune Response and Inflammation
Center for Biologics Evaluation and Research
2015-2025
United States Food and Drug Administration
2015-2017
Institute of Virology of the Slovak Academy of Sciences
2002
The poor performance of 2014-15 Northern Hemisphere (NH) influenza vaccines was attributed to mismatched H3N2 component with circulating epidemic strains. Using human serum samples collected from 2009-10, 2010-11 and NH vaccine trials, we assessed their cross-reactive hemagglutination inhibition (HAI) antibody responses against recent H3 isolates. All three populations (children, adults, older adults) vaccinated the egg- or cell-based vaccine, showed >50% reduction in HAI post-vaccination...
Abstract Vaccines against SARS-CoV-2 have targeted the spike protein and been successful at preventing disease. However, with emergence of variants, spike-specific vaccines become less effective. The nucleocapsid is relatively conserved among variants a candidate for addition to in next generation induction T cell protection. Previous studies on SARS-CoV suggested that an immune response could result enhanced Using K18-hACE2 mouse model we investigated immunization variant nucleocapsid, from...
Effectiveness of seasonal influenza vaccines mainly depends upon how well vaccine strains represent circulating viruses; mismatched can lead to reduced protection. Humans have complex exposure histories that increase with age, which may different postvaccination responses emerging variants. Recent observational studies also suggest prior vaccination influence the performance current vaccines.To elucidate effects age and preexposures on cross-reactivity vaccination-induced human antibodies,...
A hepatitis B vaccination (HepB) series with an initial dose of immune globulin (HBIG) is the recommended prophylaxis for infants born to mothers chronic virus (HBV) infection and HBV-exposed persons without known protection. The HepB HBIG are administered at different sites (limbs). Instances same site documented but impact on responses remains unanswered.Newborn adult BALB/c mice received one time zero alone or in sites, followed by 2 additional doses 3 10 weeks (newborn mice) 4 16 (adult...
In this study, we evaluated the immunogenicity and protective immunity of in vitro transcribed Venezuelan equine encephalitis virus (VEEV TC-83 strain) self-amplifying RNA (saRNA) encoding SARS-CoV-2 spike (S) protein wild type (S-WT) stabilized pre-fusion conformations (S-PP). Immunization with S-WT S-PP saRNA induced specific neutralizing antibody responses both K18-Tg hACE2 (K18) BALB/c mice, as assessed using pseudotyped viruses. Protective was challenge experiments. Two immunizations...