A5082482281- Natural product bioactivities and synthesis
- Natural Compound Pharmacology Studies
- Rheumatoid Arthritis Research and Therapies
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Cytokine Signaling Pathways and Interactions
- Sirtuins and Resveratrol in Medicine
- Vagus Nerve Stimulation Research
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Nicotinic Acetylcholine Receptors Study
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- NF-κB Signaling Pathways
- Calcium signaling and nucleotide metabolism
- Biological Activity of Diterpenoids and Biflavonoids
- Sphingolipid Metabolism and Signaling
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Toxin Mechanisms and Immunotoxins
- Autoimmune and Inflammatory Disorders Research
- Receptor Mechanisms and Signaling
- Berberine and alkaloids research
- Acute Lymphoblastic Leukemia research
First Affiliated Hospital of Wannan Medical College
2016-2025
Wannan Medical College
2015-2025
WuXi AppTec (China)
2020-2021
Nanjing University of Chinese Medicine
2014-2020
Jiangsu Province Hospital
2020
Zhejiang University
2019
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2019
University of Benin
2019
Anhui University of Traditional Chinese Medicine
2015-2016
Anhui Medical University
2013-2016
Qing-Luo-Yin (QLY) is a traditional Chinese medicine (TCM) formula used to treat Hot Syndrome-related rheumatoid arthritis (RA). Previously, we uncovered partial mechanisms involved in the therapeutic actions of QLY on RA. In this study, further elucidated its anti-rheumatic and investigated possible interactions with methotrexate (MTX) vivo using an integrating strategy coupled network pharmacology metabolomics techniques. Chemical composition was characterized by HPLC analysis. Collagen...
IGFBP5 is a differentially expressed gene (DEG) between M1 and M2 macrophages. This study explained why it causes opposite effects in different circumstances. Gene expression profiles of various cell subsets were compared by mining public database. THP-1 cells treated siRNAs, recombinant IGFBP5, lipopolysaccharide (LPS), picropodophyllin, IGF1 or the combinations. Clinical implication changes was investigated using rheumatoid arthritis (RA) acute lung injury (ALI) models. IGFBP5-bound...
Introduction: The use of environmentally benign resources for nanoparticles synthesis is consistently pushed to the front burner in a bid ensure and enhance environmental protection beneficiation. In this light, application different plant parts reduction stabilization gaining popularity. Materials Methods: contribution, we have exploited Securidaca inappendiculata stem extract (SISE), as reducing stabilizing agent room temperature highly stable dispersed AgNPs. major bioactive compounds...
Abstract Background and Purpose White adipose tissue (WAT) is involved in rheumatoid arthritis (RA). This study explored its potential as an antirheumatic target. Experimental Approach WAT status of healthy adjuvant‐induced (AIA) rats were compared. The contribution to RA pathology was evaluated by pre‐adipocyte transplant experiments dissecting perirenal fat pads AIA rats. impact on investigated culturing pre‐adipocytes. Proteins differentially expressed identified the UPLC/MS 2 method....
Metabolic intervention is a novel anti-rheumatic approach. The glycolytic regulator NAMPT has been identified as therapeutic target of rheumatoid arthritis (RA), while other metabolic regulators coordinating to perpetuate inflammation are yet be investigated. We continuously monitored and validated expression changes Nampt inflammatory indicators in peripheral blood cells from rats with collagen-induced (CIA). Gene transcriptional profiles Nampt+ Nampt++ samples identical CIA were compared...
The B7 gene family has crucial roles in the regulation of adaptive cellular immunity. In cancer, deregulation co-inhibitory molecules is associated with reduced antitumor immunity and cancer immune evasion. FDA approval immunotherapy antibodies against cytotoxic T lymphocyte-associated protein 4 (CTLA-4) programmed cell death-1 (PD-1)—both ligands family—demonstrate impact these checkpoint regulators cancer. Using data from cBioPortal, we performed comprehensive molecular profiling 10...
Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) diterpenoid isolated from Tripterygium wilfordii Hook. f., traditional Chinese medicine. It was demonstrated our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (including A549/Taxol, MCF-7/ADR and Bel7402/5-Fu). The present designed to investigate its anti-proliferative activity A549/Taxol cells, explore underlying mechanism action. cells assessed...
A previously validated anti-rheumatic compound α-mangostin (MAN) shows significant metabolism regulatory effects. The current study aimed to clarify whether this property contributed its inhibition on synovial angiogenesis. Male wistar rats with adjuvant-induced arthritis (AIA) were orally treated by MAN for 32 days. Afterwards, biochemical parameters and cytokines in plasma determined corresponding kits, glycometabolism-related metabolites further accurately quantified LC-MS method....
A previously identified anti-rheumatic compound α -mangostin (MAN) possesses notable metabolism regulatory properties. In this study, we investigated the immune implication of MAN-altered fat on adjuvant-induced arthritis (AIA) in rats. Seven days after AIA induction, rats received oral treatment MAN at 50 mg/kg/day for 30 days. Metabolic indicators and basic clinical parameters were evaluated using samples collected day 20 38 since immunization. Expression nicotinamide...
Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes. Fresh RA patients' whole blood was transfused into NOD-SCID mice. Metabolism-regulatory tissues were examined after sacrifice. To verify findings, rats with long-lasting adjuvant-induced (AIA) analyzed. Some injected human plasma and GPIHBP1, their TG monitored. Various cells stimulated by cytokines or subjects' serum. pre-adipocytes...
Introduction: Qing-Luo-Yin (QLY) is an anti-rheumatic herbal formula potentially activating PPARγ. The study investigated if and how this property contributes to its anti-angiogenesis effects. Methods: Adjuvant-induced arthritis (AIA) rats were orally treated by QLY or rosiglitazone (a PPARγ agonist), their monocytes lymphocytes co-cultured reciprocally in vitro with different sera. Healthy littermates received blood transfusion from QLY-treated AIA model rats. Two days ahead of sacrifice, a...
The rhizome of Dioscorea spongiosa is used in Chinese herbal medicine as Bixie (BX), a drug with antirheumatic effects. To explore the mechanisms underlying its antiangiogenic actions, adjuvant-induced arthritis (AIA) rats were administered BX extract for 28 days. therapeutic efficacy was evaluated by serological, histological, and immunohistochemical tests. Metabolites quantified kits UPLC-MS. separated into 30 fractions silica gel chromatography. effects reagents assessed based on...
α-Mangostin (MG) is a versatile bioactive compound isolated from mangosteen and possesses significant pharmacokinetic shortages. To augment the potential clinical efficacy, MG-loaded self-microemulsion (MG-SME) was designed prepared in this study, its as drug loading system evaluated based on performance tissue distribution feature. The formula of MG-SME optimized by an orthogonal test under guidance ternary phase diagram, characterized encapsulation efficiency, size distribution,...
Studies have shown that α-mangostin (MG) could exert anti-rheumatic effects in vivo by restoring immunity homeostasis, and indicated activation of the choline anti-inflammatory pathway (CAP) may contribute to this immunomodulatory property. The current study was designed further investigate MG on CAP peripheral immune cells clarify its relevance potential actions.The catalytic activity acetylcholinesterase (AChE) expression α7-nicotinic cholinergic receptor (α7nAChR) blood mononuclear...
Background: Exact roles of many metabolic regulators in rheumatoid arthritis (RA) are to be clarified. This study aimed further characterize the impacts silent information regulator 1 (SIRT1) status changes on this disease. Methods: Fluctuation pattern SIRT1 expression adjuvant-induced (AIA) rats was monitored using periodically collected white blood cells. Another bath AIA were treated by agonist resveratrol. Blood from these used separate monocytes and plasma, which subjected polymerase...