A5101487858- Organic Chemistry Synthesis Methods
- Analytical Chemistry and Chromatography
- Respiratory viral infections research
- Influenza Virus Research Studies
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Nutritional Studies and Diet
- SARS-CoV-2 and COVID-19 Research
- Chemical Synthesis and Analysis
- Zoonotic diseases and public health
- Chemical synthesis and pharmacological studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Diabetes Treatment and Management
- Hepatitis C virus research
- Climate Change and Health Impacts
- Liver Disease Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Synthesis of heterocyclic compounds
- Bioactive Compounds and Antitumor Agents
- Traditional Chinese Medicine Studies
- Retinal and Optic Conditions
- Air Quality and Health Impacts
- Synthesis and Characterization of Heterocyclic Compounds
- Gout, Hyperuricemia, Uric Acid
National Clinical Research Center for Digestive Diseases
2024
Capital Medical University
2021-2024
Beijing Friendship Hospital
2021-2024
Peking University
2013-2024
Fujian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Peking University People's Hospital
2024
Beijing Center for Disease Prevention and Control
2016-2023
China Medical University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
A simple and sensitive high-performance liquid chromatographic method is described for the quantitative analysis of ciprofloxacin in pharmaceuticals human plasma. The employs reversed-phase chromatography using an RP-C18 column with isocratic mobile phase acetonitrile-2% acetic acid aqueous solution (16:84, v/v), umbelliferone as internal standard, a flow rate 1.0 mL/min. UV detector set at 280 nm. limit detection 0.25 microM (S/N = 3, injection volume 10 microL). regression equations are...
Associations between size-fractionated indoor particulate matter (PM) and black carbon (BC) heart rate variability (HRV) (HR) in elderly women remain unclear. Twenty-nine healthy were measured for 24-hour HRV/HR indices. Real-time PM BC monitored on the same day preceding day. Mixed-effects models applied to investigate associations pollutants Increases significantly associated with declines power high-frequency band (HF), low-frequency (LF), standard deviation of all NN intervals (SDNN)....
SUMMARY Information on morbidity burden of seasonal influenza in China is limited. A multiplier model was used to estimate the incidence and number outpatient visits for by age group 2015–2016 season Beijing, capital China, based reported numbers influenza-like illness consultations proportions positive cases from surveillance systems general consultation rates other parameters previous studies, surveys systems. An estimated total 1 190 200 (95% confidence interval (CI) 830 400–1 549 900)...
Dementia is one of the most disabling and burdensome health conditions worldwide. In this study, we identified new potential risk factors for dementia from nationwide longitudinal population-based data by using Bayesian statistics. We first tested consistency results obtained statistics with those classical frequentist probability 4 recognized dementia, namely severe head injury, depression, diabetes mellitus, vascular diseases. Then, used to verify 2 hearing loss senile cataract, determined...
The trans-fused gamma-lactone ring of etoposide is readily epimerized to its cis epimer, which biologically inactive, or metabolized the inactive ring-opened hydroxy acids. Modification this 4 beta-(arylamino)-4'-O-demethyl-4-desoxypodophyllotoxin resulted in several compounds (15-16, 21-22, and 24) that should block epimerization resulting biological deactivation. In a topoisomerase II inhibition assay, 21, 22, 24 showed comparable activity etoposide. protein-linked DNA complex formation 21...
The aims of this study were to assess sensory recovery and impact on life quality after tongue reconstruction oncological defects using different flap types. Thirty-two patients who underwent for 9·3 months surgery with non-innervated radial forearm free flaps (RFFFs) (N = 16), anterolateral thigh (ALTFFs) 8) nasolabial island (NLIFs) 8), 20 age- gender-matched healthy controls participated in the study. modalities assessed cold detection threshold, warm threshold (WDT), pain heat (HPT),...
Behçet's disease (BD) is a recurrent, multisystemic, inflammatory disorder that mainly affects blood vessels. Because recurrent inflammation of vessels in the brain plays crucial role development ischemic stroke, we hypothesized patients with BD might have an elevated risk stroke. This potential association has been suggested few case reports, but not epidemiological studies. Hence, present study aimed to examine relation between and subsequent stroke Taiwan using nationwide,...
Synthesis of the N-substituted 1,6-dihydro-3(2H)pyridinones (3, 5 , and 9) 1-acyl-3-piperidones (l 10) is described.1-Benzylpiperidine-3,5-dione (1) was converted into 1,6-dihydro-3(2H)-pyridinones 6 via methyl en01 ethers (2, 5, 8).Selective reduction -6 9 with Et3SiH in presence TiC14 produced 1acyl-3-piperidones (? 10).Recently, 1,6-dibydro-3(2H)-pyridinone system has been reported by M. Hanaoka his co-workers1 to be a potential synthon many kinds alkaloid syntheses, 1-acyl-3-piperidone...
Dengue fever (DF) is the most rapidly spreading mosquito-borne viral disease. Practical vaccines or specific therapeutics are still expected. Environmental factors and genetic affect susceptibility of virus (DV) infection. Asthma a common allergic disease, with house dust mites (HDMs) being important allergens. Asthmatic patients susceptible to several microorganism infections. A nationwide population-based cohort analysis was designed assess whether determine asthma can be risk factor for...
Dementia is one of the most burdensome illnesses in elderly populations worldwide. However, literature about multiple risk factors for dementia scant. To develop a simple, rapid, and appropriate predictive tool clinical quantitative assessment dementia. A population-based cohort study. Based on Taiwan National Health Insurance Research Database, participants first diagnosed with from 2000 to 2009 aged ≥65 years were included. logistic regression model Bayesian supervised learning inference...
This paper briefly introduces the definition, classification and significance of effect modification in epidemiological studies, summarizes difference between modifier confounders, analyze influence as well role studies Meta-analysis. In this paper, possible scenarios related analysis strategy Meta-analysis are indicated by graphics, aiming to arouse researchers' attention modification. also demonstrates how identify deal with through a study case "Efficacy sodium-glucose cotransporter 2...
This paper briefly introduces the characteristics, research significance, and global reporting status of effect modification in network Meta-analysis, demonstrates heterogeneity caused by emphasizes importance exploring Meta-analysis. also summarizes normalized description analysis strategies Finally, case "comparison efficacy three new hypoglycemic drugs reducing body weight type 2 diabetes patients", this realization subgroup Meta-regression modification, advantages disadvantages two...
Abstract Background the role of uric acid (UA) in chronic kidney disease (CKD) remains controversial. In this study, effects UA levels on risk function (KF) decline patients with normal or mildly decreased KF at baseline were investigated. Methods Data extracted from community-based Tongzhou Cohort Study. The cohort 4246 was divided into group (estimated glomerular filtration rate [eGFR] ≥ 90 mL/min/1.73 m2) (60 ≤ eGFR < m2). primary endpoint decline, which defined as a composite 30%...
To enhance the understanding of rhabdomyolysis (RM) caused by snakebites and to promptly identify intervene in risk factors associated with RM. A retrospective analysis involving 209 snakebite victims who visited our hospital for cases was conducted. Among these, 43 were related RM, while 166 did not exhibit RM (NRM). The clinical characteristics, treatment, prognostic outcomes both groups statistically analyzed, aim interpreting concurrent through logistic regression analysis. Snakebite...