Lithium inhibits glycogen synthase kinase-3, which is an enzyme involved in the pathogenesis of cancer.To investigate association between lithium and cancer risk patients with bipolar disorder.A retrospective cohort study was designed using National Health Insurance Research Database (NHIRD) Taiwan. Patients comprised index drug group anticonvulsants only control group. Time-dependent Cox regression used to evaluate hazard ratios (HRs) for cancer.Compared anticonvulsant-only exposure,...

This study aimed to evaluate the survival rate of women with breast cancer (BC) comparing persistence versus interruption and adherence non-adherence adjuvant hormonal therapy (HT) in Asian population. Newly-diagnosed BC from 2003 2010 were retrospectively identified Taiwan National Health Insurance Research Database. HT prescriptions extracted define treatment medication possession ratio. Their impacts on mortality estimated by Cox regression time dependent covariates. Interruption (HR:...

The goal of these studies was to examine the potential utility bladder instilled K + channel gene therapy with hSlo cDNA (i.e., maxi-K channel) ameliorate overactivity in a rat model partial urinary outlet obstruction. Twenty-two female Sprague-Dawley rats were subjected urethral outlet) obstruction, 17 sham-operated control run parallel. After 6 wk suprapubic catheters surgically placed dome all rats. Twelve obstructed received instillation 100 μg hSlo/pcDNA 1 ml PBS during catheterization,...

Abstract Cutaneous wounds are prompt to be contaminated by bacteria, but the clinical benefits of applying antibiotics and antiseptics in wound management have not been proven. Statins 3‐hydroxy‐3‐methylglutaryl‐coenzyme A ( HMG‐CoA ) reductase inhibitors commonly used lower cholesterol levels. Studies indicated that statins, especially simvastatin, promote healing experimental models. As Staphylococcus aureus is one most important microorganism responsible for infections, aims this study...

Tuberculosis (TB) and hepatitis C virus (HCV) infection contribute to major disease mortality morbidity worldwide. However, the causal link between HCV TB risk remains unclear. We conducted a population-based cohort study elucidate association by analyzing Taiwan National Health Insurance Database. enrolled 5454 persons with 54,274 age- sex-matched non-HCV-infected January 1998 December 2007. Time-dependent Cox proportional hazards regression analysis was used measure active disease....

Gefitinib and erlotinib are the first-line tyrosine kinase inhibitors (TKI) for advanced non-small-cell lung cancer. However, co-administration of either drug with proton pump (PPI) or histamine-2 receptor antagonists (H2RA) may reduce TKI's bioavailability. Therefore, we aimed to investigate effects these drug-drug interactions. We surveyed nationwide population-based databases between Jan 1, 2010, Dec 30, 2018. Newly diagnosed patients adenocarcinoma who received gefitinib were identified....

Abstract We aim to investigate the role of medication adherence history in treatment needed diabetic retinopathy (TNDR). conducted a retrospective nested case–control study using 3 population-based databases Taiwan. The major one was 2-million-sample longitudinal health and welfare database from 1997 2017, nationally representative random sample National Health Insurance Administration enrolled beneficiaries 2010 (LHID2010). national death registry cancer were also checked verify...

Pneumonia is the leading cause of death in patients with Parkinson's disease (PD). However, few studies have been performed to explore risk factors for pneumonia development PD.We conducted a nationwide population-based cohort study PD identify these developing pneumonia. Participants newly diagnosed between 2000 and 2009 were enrolled from 2000-2010 National Health Insurance Research Database Taiwan. We compared an incidence hospitalization vs those without, Cox proportional hazard models...

The aim of this study is to investigate whether use cyclooxygenase-2 (COX-2) inhibitors as auxiliary drug in colorectal cancer (CRC) patients will lead better survival outcome. This population-based retrospective cohort was conducted using the Taiwan National Health Insurance Research Database. consisted newly diagnosed CRC adult during 2003-2010 with at least one prescription nonsteroidal anti-inflammation drugs. Analysis groups were defined users or nonusers COX-2 based on their usage...

Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by inhibiting tumor angiogenesis proliferation. The effect of on survival esophageal gastric is still unclear. This study to investigate the association between usage prognosis.This retrospective cohort identified during 2008-2016 from Taiwan Cancer Registry, obtained medication follow-up...

The aim of this study was to quantify the hormone therapy (HT) nonadherence patterns and assess associated risk factors in Asian women with breast cancer. This retrospective cohort used Taiwan Health Insurance Research Database from 2003 2011. Data newly diagnosed primary cancer were identified, persistence (without HT prescribing gap ≥ 180 days) defined through records dispensing prescriptions. Study cohorts further classified as adjuvant groups. Each individual's utilization medication...

The aim of this study was to clarify the association between various antipsychotic formulations—oral-daily antipsychotics (OAPs), long-acting injectable (LAIs), and their combination—and risk sudden cardiac death (SCD). We conducted a nationwide population-based case–control using data from 2011 2020 National Health Insurance Research Database multiple-cause-of-death Taiwan. included patients with new diagnosis schizophrenia who were followed for SCD occurrence until 2020. Cases controls...

This study aimed to use a competing risk approach evaluate the probability of occurrence hormone therapy (HT) interruption and assess its associated predictors in Asian women with breast cancer.This retrospective cohort used Taiwan Health Insurance Research Database from 2003 2011. Reimbursement data for newly diagnosed primary cancer were extracted. Interruption (gap ≥ 180 days) time first HT identified. The was analysed by Kaplan-Meier (KM) method cumulative incidence (CICR) method....

Three first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are widely available to treat advanced lung adenocarcinoma harboring EGFR mutation. However, studies comparing efficacy or effectiveness of these TKIs came out with inconclusive results. In this real-world data analysis a nationwide retrospective cohort design, adult patients newly diagnosed mutation between 2011 and 2016, who received TKI, were included. Overall survival (OS) time next treatment...

This study aimed to evaluate and compare the effectiveness safety between clopidogrel ticagrelor in acute coronary syndrome (ACS) with renal dysfunction.We conducted a retrospective cohort on patients chronic dialysis whose admission diagnosis 1 July 2013 31 December 2016 included ACS. The primary endpoint was major adverse cardiovascular event (MACE), bleeding event. application of propensity scores through inverse probability treatment weighting (IPTW) applied groups. Cox regression used...

This study compared the recurrence risk of single versus dual adjuvant radiotherapy (RT) and hormonal therapy (HT) following breast-conserving surgery (BCS) in patients with hormone receptor-positive ductal carcinoma situ (DCIS).

Abstract Aims New-generation breakpoint cluster region-Abelson tyrosine kinase inhibitors (TKIs) have a higher incidence of cardiovascular events than imatinib in patients with chronic myeloid leukaemia (CML). However, this knowledge is insufficiently proven. Hence, study aimed to explore the association between and TKIs CML. Methods results This retrospective population-based cohort enrolled first-time users imatinib, dasatinib, nilotinib 1 January 2007 31 December 2016. Arterial...

Venous thromboembolism (VTE) is one of the severe complications total hip arthroplasty (THA) and knee (TKA). The incidence VTE could be reduced if preventive antithrombotic medicines are used; however, bleeding may increase. Rivaroxaban a factor Xa inhibitor that prevents after THA or TKA. This study designed to confirm efficacy safety rivaroxaban in Taiwan. retrospective database based on data 6996 patients provided by Taiwan National Health Insurance Research Database from 2008 2012....

Traumatic brain injury (TBI) patients are recommended to receive anti-seizure medication (ASM) as posttraumatic seizure (PTS) prophylaxis. However, the utilization of ASM, including prescription patterns and associated clinical characteristics, is limited in Taiwan. Thus, this study aimed investigate ASM trends characteristics. This retrospective cohort enrolled TBI who received levetiracetam, phenytoin, valproic acid during hospitalization using National Health Insurance Research Database...

Background: Multimorbidity and polypharmacy increase the risk of hospitalization in older adults receiving potentially inappropriate medication (PIM). The current study compared ability PIM-Taiwan, PRISCUS, Beers criteria to predict 90-day rehospitalization patients with without PIM. Methods: retrospective cohort used Taiwan’s Longitudinal Health Insurance Database retrieve quarterly information about prescribed for aged ≥65 years hospitalized between 2001 2018. We analyzed association PIM...