A5101571532- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Livestock Farming and Management
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- HVDC Systems and Fault Protection
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Infant Nutrition and Health
- Genomic variations and chromosomal abnormalities
- PI3K/AKT/mTOR signaling in cancer
- Cell Adhesion Molecules Research
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Peripheral Neuropathies and Disorders
- Chromosomal and Genetic Variations
- Hippo pathway signaling and YAP/TAZ
Weifang People's Hospital
2023-2024
Weifang Medical University
2023-2024
Affiliated Hospital of Jining Medical University
2018-2024
Jining Medical University
2018-2023
Xidian University
2020-2022
Northwest A&F University
2013-2020
Central South University
2016-2020
Central Hospital of Zibo
2020
Xuzhou No.1 People's Hospital
2020
Xuzhou Medical College
2020
Abstract Gefitinib has been widely applied for the treatment of lung adenocarcinoma (LUAD). However, long-term application gefitinib usually leads to acquired drug resistance in tumour patients, resulting clinical failure. Small nucleolar host gene 17 (SNHG17) shown play a regulatory role LUAD progression. Nevertheless, SNHG17 remains elusive. The expression pattern was examined tissues and cell lines gefitinib-sensitive gefitinib-resistant LUAD, respectively. Gain- loss-of-function...
The pathogenesis of lung cancer, the most common is complex and unclear, leading to limited treatment options poor prognosis. To provide molecular insights into cancer development, we investigated function underlying mechanism SH2B3 in regulation cancer. We indicated was diminished while TGF-β1 elevated tissues cells. Low level correlated with prognosis patients. overexpression suppressed cell anoikis resistance, proliferation, migration, invasion, EMT, promoted those processes via reducing...
Lung cancer is the most common malignancies worldwide. However, detailed molecular mechanisms underlying lung progression are still not completely clear. MicroRNAs small noncoding RNAs which occupy a crucial role of metastasis. Accumulating evidence suggests that miR-361 plays important roles in human carcinogenesis. its precise biological remains largely elusive, especially cancer. This study examined miR-361-3p non-small cell (NSCLC). Real-time quantitative PCR (qRT-PCR) was used to...
Abstract Background Long intergenic non-coding RNA 00963 (LINC00963) is an oncogenic lncRNA in human cancers. However, little known on how it impacts the pathogenesis of lung adenocarcinoma (LUAD). Methods Biological effects proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) were examined by CCK-8, colony formation, EdU incorporation, transwell, immunofluorescence assays, respectively. Macrophage polarization was evaluated flow cytometry. Ubiquitination Zeb1...
Abstract Background The domestic buffalo (Bubalus bubalis) is an essential farm animal in tropical and subtropical regions, whose genomic diversity yet to be fully discovered. Results In this study, we describe the demographic events selective pressures of by analyzing 121 whole genomes (98 newly reported) from 25 swamp river breeds. Both uniparental biparental markers were investigated provide final scenario. ancestors diverged ~0.23 million years ago then experienced independent histories....
Abstract There is a paucity of comprehensive knowledge pertaining to the underlying mechanisms leading gefitinib resistance in individuals diagnosed NSCLC harboring EGFR-sensitive mutations who inevitably develop treatment within six months one year. In our preceding investigations, we have noted marked upregulation IGFBP2 neoplastic tissues NSCLC, predominantly periphery tissue, implying its plausible significance NSCLC. Consequently, current research, delved into matter and ascertained...
Abstract Protein Kinase cAMP-Dependent Regulatory Type I Alpha (PRKAR1A) is a tissue-specific extinguisher that transduces signal through phosphorylation of different target proteins. Loss PRKAR1A was frequently observed in endocrine neoplasia and stromal cell tumors. However, few cases were seen epithelial Previously, we first found downregulated lung adenocarcinoma patients. Thus, the present study aimed to clarify its clinical implication biological function as tumor suppressor...
Abstract Background Growing evidence suggests that suppressor of tumorigenicity 7 antisense RNA 1 (ST7-AS1) is an oncogenic long noncoding (lncRNA). However, little known on its clinical significance, biological functions, or molecular mechanisms in lung adenocarcinoma (LUAD). Methods The expression ST7-AS1 and miR-181b-5p were examined by qRT-PCR. correlations between level different clinicopathological features analysed. In vitro, LUAD cells for cell viability, migration invasion MTT,...
Long non-coding RNAs (lncRNAs) are important regulators in diabetic nephropathy. In this study, we investigated the potential role of lncRNA TUG1 regulating endoplasmic reticulum stress (ERS)-mediated apoptosis high glucose induced renal tubular epithelial cells. Human cell line HK-2 was challenged with following transfection TUG1, miR-29c-3p mimics or inhibitor expression plasmid, either alone combination, for different experimental purposes. Potential binding effects between and...
Long non-coding RNAs (lncRNAs) have been found to play regulatory roles in cancers; for example, UCC was reported promote colorectal cancer progression. However, the function of non-small-cell lung (NSCLC) remains unclear. Therefore, mRNA and protein levels were assessed using qPCR western blots. Cell viability by colony-formation assays. The interaction between lncRNAs miRNAs detected dual-luciferase reporter RIP tumorigenesis NSCLC cells vivo determined xenograft LncRNA highly expressed...
BackgroundLung cancer is one of the malignant tumors with highest morbidity and fatality rates worldwide. The overall survival (OS) lung adenocarcinoma (LUAD) poor. Cuproptosis a copper-triggered modality mitochondrial cell death, however, its contribution to emergence unknown. clinical implication immunological function cuproptosis-related genes (CRGs) in LUAD has yet be established.MethodsTCGA, HPA, GEPIA, Kaplan-Meier, TIMER CancerSEA database were used explore prognostic value biological...
Background: Esophageal carcinoma (ESCA) is one of the most prevalent malignant tumors in world. The prognosis patients has significantly improved with development surgery, targeted therapy and immunotherapy. But 5-year survival rate ESCA still incredibly low. Cuproptosis a type mitochondrial cell death induced by copper. It unclear how cuproptosis-related lncRNAs (CRLs) affect prognosis. Methods: In this study, we obtained clinical data patients, transcriptome from TCGA identified CRLs...
Non-small cell lung cancer (NSCLC), the most prevalent type of human cancer, is characterized by many molecular abnormalities. SH2B1, a member SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers. The objective this study was investigate role SH2B1 and underlying mechanism NSCLC. Cell functional analysis line-derived xenograft model were performed determine potential roles on NSCLC proliferation vitro vivo. In assays identify signal...
Lung adenocarcinoma (LADC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers, including LADC. However, mechanisms underlying SH2B1 overexpression are not completely understood. Here, we reported that expression levels were significantly upregulated and positively associated with EMT markers poor patient survival LADC specimens....
Abstract The domestication of swamp buffalo ( Bubalus bubalis carabanesis ) has been discussed for years and still remained unclear. To obtain a better understanding where, when how the buffaloes were domesticated, complete mitochondrial DNA D‐loop sequences 1,788 individuals from China, Vietnam, Laos, Thailand, Burma, Bangladesh India investigated. Our results revealed with abundant genetic diversity. lineage SA may be first domesticated in Lower Yangtze then migrated following two...
The SH2B1 adaptor protein is recruited to multiple ligand-activated receptor tyrosine kinases that play important role in the physiologic and pathologic features of many cancers. purpose this study was assess expression explore its contribution non-small cell lung cancer (NSCLC). Methods: 114 primary NSCLC tissue specimens analyzed by immunohistochemistry correlated with clinicopathological parameters patients' outcome. Additionally, 15 paired background tissues, 5 lines a normal HBE line...
Tandem duplication (TD) is an important type of structural variation (SV) in the human genome and has biological significance for cancer evolution tumor genesis. Accurate reliable detection TDs plays role advancing early detection, diagnosis, treatment disease. The advent next-generation sequencing technologies made it possible study TDs. However, still challenging due to uneven distribution reads uncertain amplitude TD regions. In this paper, we present a new method, DINTD (Detection...
Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge tumor treatment. A high dose of PTX was used for cell lines to analyze the changes molecular expression. The miR-378d sharply reduced surviving cells, but role Esophageal squamous carcinoma (ESCC) remained unclear.We analyzed relationship between expression and clinicopathological features ESCC. We constructed silent study phenotypes mechanisms.The associated with good prognosis patients inhibition promoted...