A5100457636- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Cellular transport and secretion
- Thyroid Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Free Radicals and Antioxidants
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- AI in cancer detection
- Bacteriophages and microbial interactions
- Kruppel-like factors research
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
Affiliated Hospital of Jining Medical University
2020-2025
First Affiliated Hospital of Bengbu Medical College
2021
Harbin Medical University
2015-2017
Second Affiliated Hospital of Harbin Medical University
2015-2017
Nantong University
2016
Affiliated Hospital of Nantong University
2016
Peking Union Medical College Hospital
2008-2012
State Key Laboratory of Digital Medical Engineering
2010
Southeast University
2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a marker of cancer stem-like cells (CSCs), but knowledge about the molecular mechanism ALDH1A1 in maintaining properties CSCs remains limited. immunohistochemistry was performed esophageal squamous cell carcinoma (ESCC) tissues, Western blotting used to detect relationship between and AKT or β-catenin. Subcutaneous transplantation tumors drug resistance, spherogenesis experiments were test ESCC stemness. Co-IP confocal detected co-localization LADH1A1...
The abnormal phenotypic transformation of vascular smooth muscle cells (SMCs) causes various proliferative diseases. MicroRNAs (miRNAs or miRs) have been established to play important roles in SMC biology and modulation. This study revealed that the expression miR‑182 was markedly altered during rat vitro. We aimed investigate role switch determine potential molecular mechanisms involved. gene significantly downregulated cultured SMCs dedifferentiation from a contractile synthetic phenotype....
Ovarian cancer is a leading cause of death among gynaecologic malignancies. Despite many years research, it still remains sparing in reliable diagnostic markers and methods for early detection screening. Transforming growth factor β-activated protein kinase 1 (TAK1)-binding 3 (TAB3) was initially characterized as an adapter essential TAK1 activation response to IL-1β or TNFα, however, the physiological role TAB3 ovarian tumorigenesis not fully understood. In this study, we evaluated effects...
<i>Objectives:</i> To construct a one-plasmid expression system of the armored RNA containing long chimeric byincreasing number and affinity <i>pac site</i>. <i>Methods:</i> The plasmid pET-MS2-<i>pac</i> was constructedwith one C-variant site,</i> then pM-CR-2C 1,891-bp sequences two sites</i> produced. Meanwhile, three plasmids (pM-CR-C, pM-CR-2W pM-CR-W) were obtained as parallel controls with different Finally, expressed...
Although much is known about microRNAs' regulation in gene expression and their contributions cell fate, to date, globally lineage-(cell-) specific identification of the binding events between a transcription factor its targeting microRNA genes still waiting for elucidation. In this paper, we performed ChIP-Seq experiment find factor, Egr1, human erythroleukemia line K562. We found Egr1 sites near promoters 124 distinct genes, accounting 42% miRNAs which have high-confidence predicted (294)....
Lymph node metastasis (LNM) significantly impacts the prognosis of individuals diagnosed with cervical cancer, as it is closely linked to disease recurrence and mortality, thereby impacting therapeutic schedule choices for patients. However, accurately predicting LNM prior treatment remains challenging. Consequently, this study seeks utilize digital pathological features extracted from histopathological slides primary cancer patients preoperatively predict presence LNM.A deep learning (DL)...
Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge tumor treatment. A high dose of PTX was used for cell lines to analyze the changes molecular expression. The miR-378d sharply reduced surviving cells, but role Esophageal squamous carcinoma (ESCC) remained unclear.We analyzed relationship between expression and clinicopathological features ESCC. We constructed silent study phenotypes mechanisms.The associated with good prognosis patients inhibition promoted...
MicroRNA-29a-3p has been reported in a variety of cancers, but its role hypopharyngeal cancer remains unclear. This study was to determine the microRNA-29a-3p occurrence and development cancer.40 patients with who underwent surgery Affiliated Hospital Jining Medical University from April 2013 November 2017 were selected for this study. The tissue samples collected, followed up three years. expression detected by situ hybridization fluorescent probe, relationships among clinicopathological...
Studies have shown that stress such as hypoxia, chemotherapy, radiotherapy can lead to polyploidization of tumor cells, which play an important role in heterogeneity and malignant phenotype. Paclitaxel (PTX) treatment promoted polyploid cancer cells (PCCs) formation, miR-378d is sharply reduced PCCs esophageal squamous cell carcinomas (ESCC) but participation formation the impact on biological behavior ESCC remains unclear. We analyzed vivo vitro, related proteins regulated by miR-378d....
<h3>Objectives</h3> Macrophage cholesterol efflux plays an important role in maintaining cellular lipid homeostasis, and preventing cells from formation of lipid-laden foam cells. Although radioactive [<sup>3</sup>H]-cholesterol was widely used as a tracer assay, time- labour-consuming assay procedure radioactivity disposal may limit its use high-throughput screening. Here, we developed new method using fluorescent NBD-cholesterol substitute for to measure THP-1 derived macrophages....
This study intends to clarify lncRNA SATB2-AS1’s role in growth, invasion and migration of nasopharyngeal carcinoma cells its effect on radiotherapy. The array was used analyze the differential expression biopsy tissues. QRT-PCR measured levels SATB2-AS1 TIMP2 along with analysis cell migration, ability by MTT method colony formation experiment. Luciferase reporter gene test assessed relationship between TIMP2. LncRNA found significantly increased Ectopic overexpression CNE1 promoted...